High Salt Intake

Ma, Yuan; He, Feng J; MacGregor, Graham A.

doi:10.1161/hypertensionaha.115.05948

Cited by 241 publications

(149 citation statements)

References 31 publications

Supporting

Mentioning

127

Contrasting

Order By: Relevance

“…Most of the study participants were either overweight (41%) or obese (25%). Recent observational studies have explored the relationship between sodium intake measured in 24-hour urine collection samples and obesity, BMI, weight, and waist circumference, with similar results to the present study (Figure 2) [22,23]. The positive correlation between increased body size parameters and higher salt consumption is considered an independent risk factor of obesity.…”

Section: Discussionsupporting

confidence: 86%

Dietary salt consumption and the knowledge, attitudes and behavior of healthy adults: a cross-sectional study from Jordan

AlAwwa

Dagash

Saleh

et al. 2018

Libyan Journal of Medicine

View full text Add to dashboard Cite

High dietary sodium is recognized as a silent killer responsible for 2.3 million deaths worldwide in 2010 predominantly secondary to hypertension and its complications. Although high salt consumption is considered a worldwide public health problem, its magnitude is highly variable among different communities; therefore, it is important to study locally. This study aimed to evaluate habitual salt consumption, its important correlations, as well as the knowledge, attitude, and behavior of healthy Jordanian citizens. As potassium consumption is highly correlated and important we aimed to study both jointly. In this descriptive cross-sectional study we enrolled 103 healthy adult Jordanian citizens. All participants were interviewed for questionnaire filling, physical examination, and instructed on proper 24-hour urine collection procedure. We measured sodium and potassium concentration in the provided controlled 24-hour urine collection samples, as it is presently considered the gold standard for evaluating daily intake. The results showed an average sodium intake of 179 mmol (4.1 g) per day [higher in males at 186 mmol (4.3 g) vs. 173 mmol (4.0 g) for females], significantly above the current WHO recommendations, though only 8% regularly add salt to food. Ironically, most participants (82%) believe their salt consumption was appropriate and only 29% thought they may benefit from reducing salt intake. On the other hand, potassium intake is far below the current WHO recommendations. High sodium and low potassium intake have synergistic adverse effects on public health that is not currently addressed in Jordan. We conclude that Jordanian citizens currently consume high sodium and low potassium diet and are mostly unaware of its negative impact on their health. Hence, it is crucial for healthcare providers to intervene and adopt long-term strategies to control salt intake to reduce its negative effects in Jordan and elsewhere.

show abstract

Section: Discussionsupporting

confidence: 86%

Dietary salt consumption and the knowledge, attitudes and behavior of healthy adults: a cross-sectional study from Jordan

AlAwwa

Dagash

Saleh

et al. 2018

Libyan Journal of Medicine

View full text Add to dashboard Cite

show abstract

“…However, we have found that high salt diets can also induce hepatic aldose reductase expression (due to effects on osmolarity) leading to endogenous fructose production and NAFLD in mice, and mice lacking fructokinase are protected (Lanaspa MA, manuscript under review). High salt diets are independently associated with metabolic syndrome/diabetes (135, 136) and NAFLD (137). Thus, it seems likely that both high glycemic diets and/or high salt diets might exacerbate fructose-induced NAFLD.…”

Section: Modulating Factorsmentioning

confidence: 99%

Fructose and sugar: A major mediator of non-alcoholic fatty liver disease

Jensen

Abdelmalek

Sullivan

et al. 2018

Journal of Hepatology

692

490

View full text Add to dashboard Cite

Nonalcoholic Fatty Liver Disease (NAFLD) is the hepatic manifestation of metabolic syndrome, and its rising prevalence parallels the rise in obesity and diabetes. Historically thought to result from overnutrition and sedentary lifestyle, recent evidence suggests that diets high in sugar (from sucrose and/or high fructose corn syrup (HFCS)) not only increases the risk for NAFLD, but also, nonalcoholic steatohepatitis (NASH). Here we review the experimental and clinical evidence that fructose precipitates fat accumulation in the liver, due to both increased lipogenesis and impaired fat oxidation. Recent evidence suggests that the predisposition to fatty liver is linked with metabolism of fructose by fructokinase C, resulting in ATP consumption, nucleotide turnover and uric acid generation that mediate fat accumulation. Alterations in gut permeability, microbiome, and associated endotoxemia contributes to the risk of NAFLD and NASH. Early clinical studies suggest that reducing sugary beverages and total fructose intake, especially from added sugars, may have a significant benefit on reducing hepatic fat accumulation. We suggest larger, more definitive trials to determine if lowering sugar/HFCS intake, and/or blocking uric acid generation, may help reduce NAFLD and its downstream complications of cirrhosis and chronic liver disease.

show abstract

“…study 42 that proves that eating salt increased the chance of obesity, independent of energy intake. Several mechanisms have been proposed for this association, including increased water consumption, a consequent increase in the volume of extracellular water, and changes in fat metabolism following salt intake.…”

Section: Discussionmentioning

confidence: 81%

Some dietary factors can modulate the effect of the zinc transporters 8 polymorphism on the risk of metabolic syndrome

Hosseini-Esfahani¹,

Mirmiran²,

Koochakpoor³

et al. 2017

Sci Rep

View full text Add to dashboard Cite

There are conflicting data on the impact of zinc transporter 8 (ZNT8) gene variations on the metabolic syndrome (MetS). Hence, the effects of the interaction between rs13266634 and dietary factors on the risk of MetS were investigated in this study. Subjects of this nested case-control study were selected from the participants in Tehran Lipid and Glucose Study. Each of the cases (n = 817) was individually matched with a control. Dietary patterns were determined using factor analysis. The ZNT8 rs13266634 were genotyped by the Tetra-refractory mutation system-polymerase chain reaction analysis. Two dietary patterns were extracted. There were no significant interactions between the ZNT8 SNP and the dietary patterns on the risk of MetS or its components. An interaction was observed between rs13266634 and the omega-3 fatty acid intakes on the risk of MetS in subjects with the CC genotype (P interaction < 0.01). Zinc modified the association of the ZNT8 variant with high fasting blood sugar (P interaction = 0.05) in CC genotype carriers. An interaction was also observed between rs13266634 and salty snacks at the risk of abdominal obesity (P interaction < 0.05). Our findings suggest an interaction between omega-3 fatty acids, zinc, salty snacks and rs13266634, which may affect the risk of MetS or its components.

show abstract

High Salt Intake

Cited by 241 publications

References 31 publications

Dietary salt consumption and the knowledge, attitudes and behavior of healthy adults: a cross-sectional study from Jordan

Dietary salt consumption and the knowledge, attitudes and behavior of healthy adults: a cross-sectional study from Jordan

Fructose and sugar: A major mediator of non-alcoholic fatty liver disease

Some dietary factors can modulate the effect of the zinc transporters 8 polymorphism on the risk of metabolic syndrome

Contact Info

Product

Resources

About