High-salt intake accelerates functional and histological renal damage associated with renal tissue overexpression of (pro)renin receptors and AT1 receptors in spontaneously hypertensive rats

Hayakawa, Yuka; Komaki, Hisaaki; Minatoguchi, Shingo; Yamada, Yoshihisa; Kanamori, Hiromitsu; Nishigaki, Kazuhiko; Minatoguchi, Shinya

doi:10.1007/s10157-020-01888-7

Cited by 10 publications

(5 citation statements)

References 19 publications

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“…Populations with a specific subtype of hypertension, salt-sensitive hypertension, manifested by significant changes in the blood pressure in response to salt intake, are at a higher risk for renal disease [ 18 ]. High-salt diet is considered a public health concern worldwide, which is associated with renal diseases [ 19 ]. Ala was reported to improve renal dysfunction of ischemia and reperfusion rats [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

Alamandine alleviates hypertension and renal damage via oxidative-stress attenuation in Dahl rats

et al. 2022

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Alamandine (Ala) is a novel member of the renin–angiotensin-system (RAS) family. The present study aimed to explore the effects of Ala on hypertension and renal damage of Dahl salt-sensitive (SS) rats high-salt diet-induced, and the mechanisms of Ala on renal-damage alleviation. Dahl rats were fed with high-salt diets to induce hypertension and renal damage in vivo, and HK-2 cells were treated with sodium chloride (NaCl) to induce renal injury in vitro. Ala administration alleviated the high-salt diet-induced hypertension, renal dysfunction, and renal fibrosis and apoptosis in Dahl SS rats. The HK-2 cells’ damage, and the increases in the levels of cleaved (c)-caspase3, c-caspase8, and c-poly(ADP-ribose) polymerase (PARP) induced by NaCl were inhibited by Ala. Ala attenuated the NaCl-induced oxidative stress in the kidney and HK-2 cells. DETC, an inhibitor of SOD, reversed the inhibitory effect of Ala on the apoptosis of HK-2 cells induced by NaCl. The NaCl-induced increase in the PKC level was suppressed by Ala in HK-2 cells. Notably, PKC overexpression reversed the moderating effects of Ala on the NaCl-induced apoptosis of HK-2 cells. These results show that Ala alleviates high-salt diet-induced hypertension and renal dysfunction. Ala attenuates the renal damage via inhibiting the PKC/reactive oxygen species (ROS) signaling pathway, thereby suppressing the apoptosis in renal tubular cells.

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Section: Discussionmentioning

confidence: 99%

Alamandine alleviates hypertension and renal damage via oxidative-stress attenuation in Dahl rats

et al. 2022

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“…A healthy gustatory system ensures that a human intakes suitable kinds and amounts of nutrients. Excessive salt intake can increase the risk of hypertension and cardiovascular disease (Figure a) . Developing a system that can monitor salt level and provide a warning if it is excessive would help to reduce these risks.…”

Section: Construction and Test Verification Of A Complete Taste Nervo...mentioning

confidence: 99%

“…These capabilities of the gustatory system can help humans intake suitable kinds and amounts of nutrients. 13,14 Multisensory "electronic tongues" (e-tongues) have been developed by emulating biological working principles, and they have been used to detect various classes of taste. 15 These devices can be divided into lipid/polymer-membrane type, 16,17 human-taste-receptor type, 18,19 and voltammetric type.…”

mentioning

confidence: 99%

“…The gustatory system can perceive and remember chemical taste stimuli and can also trigger an emergency reaction when ingesting harmful food. These capabilities of the gustatory system can help humans intake suitable kinds and amounts of nutrients. , …”

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confidence: 99%

“…This response helps to maintain healthy concentrations of Na + and Cl – ions in the body. Intaking excessive NaCl can lead to hypertension and cardiovascular disease . An artificial gustatory system with the functions of monitoring salt intake and issuing warnings upon excessive intake can effectively avoid these diseases.…”

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Neuromorphic Gustatory System with Salt-Taste Perception, Information Processing, and Excessive-Intake Warning Capabilities

Wang

Zhang

et al. 2022

Nano Lett.

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Emulation of the process of a biological gustatory system could benefit the reconstruction of sense of taste. Here we demonstrate the first neuromorphic gustatory system that emulates the ability of taste perception, information processing, and excessive-intake warning functions. The system integrates a chitosan-derived ion-gel sensor, SnO 2 nanowire artificial synapses, and an effect-executive unit. The system accomplish perception and encoding behaviors for taste stimulation without using complex circuits and multivariate analysis, showing short response delay (<1 s), long taste memory duration (>2 h), and a wide perceptive concentration range (0.02−6 wt % salt solution). Especially, SnO 2 NW artificial synapses have extremely small response voltage (1 mV), exceeding the biological level by orders of magnitude, representing so-far the highest sensitivity record. This work provides a promising strategy to develop bioinspired and biointegrated electronics with the intention of mimicking and restoring the functions of biological sensory systems.

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Impact of high salt diets on CHOP-mediated apoptosis and renal fibrosis in a rat model

et al. 2021

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High-salt intake accelerates functional and histological renal damage associated with renal tissue overexpression of (pro)renin receptors and AT1 receptors in spontaneously hypertensive rats

Cited by 10 publications

References 19 publications

Alamandine alleviates hypertension and renal damage via oxidative-stress attenuation in Dahl rats

Alamandine alleviates hypertension and renal damage via oxidative-stress attenuation in Dahl rats

Neuromorphic Gustatory System with Salt-Taste Perception, Information Processing, and Excessive-Intake Warning Capabilities

Impact of high salt diets on CHOP-mediated apoptosis and renal fibrosis in a rat model

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