High-Risk Types of Human Papillomavirus (HPV) DNA in Oral and Genital Mucosa of Infants during Their First 3 Years of Life: Experience from the Finnish HPV Family Study

Abstract

Persistent carriage of high-risk HPV types was detected in oral and genital mucosa specimens obtained from 10% and 1.5% of the infants during their first 26 months of life. The rates of acquisition and clearance of HPV were similar in oral and genital mucosa.

B7-H1 Expression Model for Immune Evasion in Human Papillomavirus-Related Oropharyngeal Squamous Cell Carcinoma

“…Studies have demonstrated that oral infection by HPV is not uncommon [3,9]. However, evidence suggests that virtually all immune competent patients clear the viral infections [10][11][12][13], supporting the hypothesis that most individuals experience only transient infection.…”

Prophylactic HPV Vaccines and Prevention of Cervical Intraepithelial Neoplasia

“…HPV 58 and 52 replace HPV 31 and 45 in Asian populations at similar distribution frequencies. Adenocarcinoma of the cervix, on the other hand, while also High-risk HPV prevalence exists at all ages, with varying amounts of increase in the perimenopausal age groups [11][12][13][14][15][16][17][18][19] HPV human papilloma virus always associated with HPV infection, is attributed to a different distributional frequency of oncogenic types. HPV 16, 18, and 45 constitute nearly 90 % of all adenocarcinomas in all parts of the world [19].…”

“…1) starting in early childhood for some. Infection prevalence peaks between 16 and 25 years of age, drops to a 10 % prevalence until the perimenopausal years, at which time there is an upsurge to near peak prevalences in many populations [11][12][13][14][15][16][17][18][19][20]. The concordance of HPV types between male and female partners is low, ranging from 2 to 35 % [21], significantly hindering any attempt to identify the transmission source.…”

Human Papillomavirus and Related Diseases - From Bench to Bedside - A Clinical Perspective

“…According to the age studied, there are variations in the prevalence rate. In nasopharyngeal aspirates collected immediately after birth, the detection rate of HPV varies from 1.5% to 37% (Cason et al, 1995;Castellsague et al, 2009;Mazzatenta et al, 1996;Puranen et al, 1996Puranen et al, , 1997Rintala et al, 2005aRintala et al, , 2005bRombaldi et al, 2008;Sedlacek et al, 1989;Tenti et al, 1997Tenti et al, , 1999Watts et al, 1998). At the age of 1-4 days, Smith et al in two studies found a low HPV incidence (from 0.9% to 1%) in the buccal swabs of neonates, whereas other studies showed a higher prevalence varying from 40% to 56% (Cason et al, 1995;Kaye et al, 1994;Pakarian et al, 1994;Tseng et al, 1998;Smith et al, 1995Smith et al, , 2004b.…”