High-Risk Neuroblastoma Challenges and Opportunities for Antibody-Based Cellular Immunotherapy
Natasha V. Persaud,
Jeong A. Park,
Nai Kong V. Cheung
Abstract:Immunotherapy has emerged as an attractive option for patients with relapsed or refractory high-risk neuroblastoma (HRNB). Neuroblastoma (NB), a sympathetic nervous system cancer arising from an embryonic neural crest cell, is heterogeneous clinically, with outcomes ranging from an isolated abdominal mass that spontaneously regresses to a widely metastatic disease with cure rates of about 50% despite intensive multimodal treatment. Risk group stratification and stage-adapted therapy to achieve cure with minima… Show more
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