High-Risk Intraocular Retinoblastoma

Kaliki, Swathi; Shields, Carol L.; Eagle, Ralph C.; Iram, Sadiya; Shields, Jerry A.

doi:10.1097/iae.0000000000001816

Cited by 23 publications

(18 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In a study of retinoblastoma patients from India and the United States of America, it was noted that Asian Indians had a fivefold greater risk of having optic nerve invasion and threefold greater risk of massive choroidal invasion compared with Americans. [ 23 ] In our study approximately 33% patients had optic nerve involvement.…”

Section: Discussionmentioning

confidence: 48%

Epidemiological profile of retinoblastoma in north India: Implications for primary care and family physicians

Gupta

Pandey

Dimri

et al. 2020

J Family Med Prim Care

View full text Add to dashboard Cite

Background: Retinoblastoma is the most common primary intraocular malignancy among children. Despite being curable in early stages, majority of the cases in India present in late stages, when outcomes are very poor. Objectives: The aim of this study was to assess the epidemiological profile, clinical characteristics, and treatment practices among retinoblastoma patients in north India. Materials and Methods: Data on all patients with retinoblastoma, over a 10-year-time period from 2009 to 2018, who were treated in a tertiary care hospital in north India, were assessed. Data were analyzed to describe the demographic characteristics, clinical features in terms of stage at presentation, and management practices in terms of diagnostic investigations and treatment. The statistical significance for difference in percentages was assessed using Fischer's exact test at a 5% significance level. Results: A total of 25 retinoblastoma patients were enlisted, of whom one was excluded as it was adult onset retinoblastoma. The median age at presentation was 3 years, with a male to female ratio of 1:1.4. Bilateral presentation was seen in 16.6% cases. Majority (66.6%) of the patients underwent magnetic resonance imaging of brain and orbit as a part of the diagnostic workup. Intraocular disease was seen in 58.3% patients, whereas 41.6% patients had extraocular disease. Local therapy with vision preservation could be used only in 8.3% patients, whereas 87.5% patients were referred for enucleation. Chemotherapy with combination of vincristine, etoposide, and carboplatin was used extensively both, in neoadjuvant setting (83.3%) and in the adjuvant setting. Conclusion: Despite availability of treatment for eye preservation, its utility is limited due to the advanced stage at presentation. Awareness about the disease and its symptoms for early diagnosis, especially with the Mid-Level Health Provider at Health and Wellness Centers, is likely to improve early reporting and treatment and meeting the Vision 2020 goals.

show abstract

Section: Discussionmentioning

confidence: 48%

Epidemiological profile of retinoblastoma in north India: Implications for primary care and family physicians

Gupta

Pandey

Dimri

et al. 2020

J Family Med Prim Care

View full text Add to dashboard Cite

show abstract

“…Studies from various countries have highlighted the importance of early diagnosis of RB and the implications of delayed treatment. Studies from Asia have shown that a delayed diagnosis of RB results in an advanced disease at presentation with poorer chances of globe salvage [11,12]; studies from the United Kingdom and India have revealed higher chances of high-risk histopathological features with subsequent need for adjuvant chemotherapy [13,14]; a study from Brazil has shown increased mortality due to increased lag time [15]; a study from Switzerland has shown that reduced lag time is associated with early stage of the disease at presentation [16]; and a study from the Netherlands has shown correlation between early diagnosis and decreased mortality and blindness [17]. Herein, we prospectively studied the lag time between onset of symptoms and diagnosis of RB in 10 countries on five continents from 1 January 2019 to 31 December 2019 and compared the results based on country income levels to assess the causes of increased lag time and its effect on the patient outcomes.…”

Section: Introductionmentioning

confidence: 99%

Lag Time between Onset of First Symptom and Treatment of Retinoblastoma: An International Collaborative Study of 692 Patients from 10 Countries

Kaliki

Zou

et al. 2021

Cancers

Self Cite

View full text Add to dashboard Cite

Background: The relationship between lag time and outcomes in retinoblastoma (RB) is unclear. In this study, we aimed to study the effect of lag time between onset of symptoms and diagnosis of retinoblastoma (RB) in countries based on their national-income and analyse its effect on the outcomes. Methods: We performed a prospective study of 692 patients from 11 RB centres in 10 countries from 1 January 2019 to 31 December 2019. Results: The following factors were significantly different among different countries based on national-income level: age at diagnosis of RB (p = 0.001), distance from home to nearest primary healthcare centre (p = 0.03) and mean lag time between detection of first symptom to visit to RB treatment centre (p = 0.0007). After adjusting for country income, increased lag time between onset of symptoms and diagnosis of RB was associated with higher chances of an advanced tumour at presentation (p < 0.001), higher chances of high-risk histopathology features (p = 0.003), regional lymph node metastasis (p < 0.001), systemic metastasis (p < 0.001) and death (p < 0.001). Conclusions: There is a significant difference in the lag time between onset of signs and symptoms and referral to an RB treatment centre among countries based on national income resulting in significant differences in the presenting features and clinical outcomes.

show abstract

“…It is the most common pediatric malignant cancer of the eye and can easily lead to the loss of either sight or the eyeball and even death during early childhood [2]. The incidence and degree of malignancy of retinoblastoma are higher in developing countries than those in developed countries; moreover, cure rates remain unsatisfactory in developing countries, with relatively high morbidity and mortality, lower rates of eye salvage and higher rates of extraocular dissemination [3–5]. Survival rates in high-income countries can be greater than 95%, while the global survival rate is less than 30% [2].…”

Section: Introductionmentioning

confidence: 99%

Clinicohistopathological implications of MMP/VEGF expression in retinoblastoma: a combined meta-analysis and bioinformatics analysis

Zhu

Zhang

et al. 2019

J Transl Med

View full text Add to dashboard Cite

Background No in-depth systematic evidence is available for assessing retinoblastoma malignancy and eligibility for subsequent treatment. Methods The Cochrane Library, EMBASE, PubMed, Web of Science, and China Biology Medicine databases were searched, and 16 studies comprising 718 retinoblastoma patients were included. Pooled odds ratios (ORs) and summary correlation coefficients (r) with 95% confidence intervals (CIs) in random-effects, fixed-effects or quality-effects models were calculated using Review Manager 5.3 and MetaXL. GO functional annotation and KEGG pathway analysis were performed using the GO and STRING databases. Results We observed significant associations between high levels of MMP-1 (OR, 4.21; 95% CI 1.86–9.54), MMP-2 (OR, 11.18; 95% CI 4.26–29.30), MMP-9 (OR, 10.41, 95% CI 4.26–25.47), and VEGF (OR, 8.09; 95% CI 4.03–16.20) with tumor invasion; high levels of MMP-1 (OR, 3.58; 95% CI 1.48–8.71), MMP-2 (OR, 2.96; 95% CI 1.32–6.64), MMP-9 (OR, 5.49; 95% CI 3.55–8.48) and VEGF (OR, 5.30; 95% CI 2.93–9.60) with poor differentiation; and overexpression of MMP-9 (OR, 5.17; 95% CI 2.85–9.38) with advanced clinical stages. Moreover, MMP-9 and VEGF expression were positively correlated (r, 0.61; 95% CI 0.38–0.77). Multiple GO terms were enriched associated with MMP-1, MMP-2, MMP-9 and VEGF, and they are closely associated with pathways, proteoglycans and microRNAs related to cancer. Conclusions MMP-1, MMP-2, MMP-9 and VEGF play important roles in the development and progression of retinoblastoma. High levels of MMP-1, MMP-2, MMP-9 and VEGF are credible implications for increased malignancy, thus the need for more aggressive treatments. Electronic supplementary material The online version of this article (10.1186/s12967-019-1975-3) contains supplementary material, which is available to authorized users.

show abstract

High-Risk Intraocular Retinoblastoma

Abstract: High-risk intraocular retinoblastoma is more common in Asian Indians compared with Americans.

Cited by 23 publications

References 38 publications

Epidemiological profile of retinoblastoma in north India: Implications for primary care and family physicians

Epidemiological profile of retinoblastoma in north India: Implications for primary care and family physicians

Lag Time between Onset of First Symptom and Treatment of Retinoblastoma: An International Collaborative Study of 692 Patients from 10 Countries

Clinicohistopathological implications of MMP/VEGF expression in retinoblastoma: a combined meta-analysis and bioinformatics analysis

Contact Info

Product

Resources

About