High-risk human papillomavirus among HIV-infected women with normal cervical cytology: a pilot study in Jos, Nigeria

Musa, Jonah; Taiwo, Babafemi; Achenbach, Chad J.; Silas, Olugbenga A.; Berzins, Baiba; Sagay, Atiene S.; Idoko, John; Kanki, Phyllis J.; Murphy, Robert L.

doi:10.1007/s00404-013-2885-x

Cited by 13 publications

(12 citation statements)

References 27 publications

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“…Kreitchmann et al (2013) studied 898 women living with HIV infection and reported that age less than 30 years was significantly associated with increased risk of abnormal cervical cytology among the women. This was similar to the account of Musa et al (2013) in Jos Nigeria who reported that age less than 30 years was significantly associated with the presence of high risk HPV DNA.…”

Section: Introductionsupporting

confidence: 89%

“…This association with a younger age had been reported by Musa et al (2013) in Jos Nigeria, Kreitchman et al (2013) and Koffi et al (2010) in Central African Republic. This association may be derived from a more aggressive sexual activity by the younger women, as HPV infection which is the precursor for the premalignant lesions is a sexually transmitted infection.…”

Section: Discussionsupporting

confidence: 68%

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Sociodemographic determinants of abnormal cervical cytology among HIV positive women in Nnewi, Nigeria

Ugboaja¹,

Oguejiofor²,

Anya³

2017

Int. J. Med. Med. Sci.

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Women living with human immunodeficiency virus (HIV) infection have a higher burden of premalignant.7, p=0.03) and the Anglicans ( 2 =6.7, p=0.04). The prevalence rate was also the highest among women who were para 0-1 (36.6%), unemployed (100.0%), with no formal education (33.3%), and those who were separated from their husbands (100.0%), but these were not statistically significant. The prevalence of cervical cytological abnormalities among the HIV positive women attending the HIV clinic in NAUTH was high. Younger age, being a trader and Anglican Christian denomination were significantly associated with increased risk of premalignant lesions of the cervix.

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Section: Introductionsupporting

confidence: 89%

Section: Discussionsupporting

confidence: 68%

Sociodemographic determinants of abnormal cervical cytology among HIV positive women in Nnewi, Nigeria

Ugboaja¹,

Oguejiofor²,

Anya³

2017

Int. J. Med. Med. Sci.

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“…HPV prevalence in HIV-infected populations is more than three times the estimated prevalence of 12% found in the general population and ranges from about 31% to 57%, with higher percentages in Africa than in North America or Western Europe (185). A pilot study conducted in Jos, Nigeria, evaluated a cohort of 97 HIV-infected women age 21 to 49 with normal cytology (186). High-risk HPV was detected by the Digene HC2 assay in almost half (44.9%) of the cohort, with a significant number of the positive patients being less than 30 years of age, and most were on successful antiretroviral therapy.…”

Section: High-risk Hpv Detection As a First-line Test In Primary Cervmentioning

confidence: 99%

Human Papillomavirus Laboratory Testing: the Changing Paradigm

2016

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SUMMARYHigh-risk human papillomaviruses (HPVs) cause essentially all cervical cancers, most anal and oropharyngeal cancers, and some vaginal, vulvar, and penile cancers. Improved understanding of the pathogenesis of infection and the availability of newer tests are changing the approach to screening and diagnosis. Molecular tests to detect DNA from the most common high-risk HPVs are FDA approved for use in conjunction with cytology in cervical cancer screening programs. More-specific tests that detect RNA from high-risk HPV types are now also available. The use of molecular tests as the primary screening tests is being adopted in some areas. Genotyping to identify HPV16 and -18 has a recommended role in triaging patients for colposcopy who are high-risk HPV positive but have normal cytology. There are currently no recommended screening methods for anal, vulvar, vaginal, penile, or oropharyngeal HPV infections. HPV testing has limited utility in patients at high risk for anal cancer, but p16 immunohistochemistry is recommended to clarify lesions in tissue biopsy specimens that show moderate dysplasia or precancer mimics. HPV testing is recommended for oropharyngeal squamous cell tumors as a prognostic indicator. Ongoing research will help to improve the content of future guidelines for screening and diagnostic testing.

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“…To assess the possible role of HR-HPV DNA testing in detecting underlying high-grade cervical lesions in women with prior NCC in the setting of HIV infection, we conducted a pilot study of HR-HPV DNA testing in women with NCC in a cohort of HIV infected women in Jos, Nigeria. The prevalence and epidemiologic factors associated with HR-HPV in our patient population have been previously reported [ 17 ]. The current report focused on colposcopic examination findings and cervical abnormalities in women with or without HR-HPV in our cohort.…”

Section: Introductionmentioning

confidence: 98%

High-risk human papilloma virus and cervical abnormalities in HIV-infected women with normal cervical cytology

Musa

Achenbach

Taiwo

et al. 2014

Infect Agents Cancer

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BackgroundThe prevalence of High-Risk Human papilloma virus (HR-HPV), a necessary cause of invasive cervical cancer (ICC) is relatively high in HIV infected women. Gaps exist in our knowledge of the optimal approaches for managing women who have HR-HPV with normal cervical cytology (NCC) particularly in settings of HIV infection.MethodsBetween May 2012 and June 2013 we conducted a colposcopic assessment of HIV-infected women with prior (NCC) and known HR-HPV status to compare cervical abnormalities in women with and without HR-HPV. Colposcopic examinations were done at the Operation Stop Cervical Cancer (OSCC) unit of the Jos University Teaching Hospital (JUTH), Jos, Nigeria. Abnormal colposcopic finding (ACF) was defined as areas of aceto-white epithelium involving the squamo-coulumnar junction, areas of punctation, mosaic pattern or atypical vessels. We compared proportions of ACF as well as histologic grades of cervical intra-epithelial neoplasia (CIN) in women with or without HR-HPV. Statistical analysis was done on STATA.ResultsWe conducted colposcopic examinations in 78 out of 89 (86.5%) eligible women. The mean age of the cohort was 32.4 years (SD ±4.6) with a median 32 years (IQR 29–36). After a mean follow up time of 20.1 months from the initial cervical pap cytology and HR-HPV testing, we found 12 of 78 (15.4%) women with ACF. The odds for an ACF was statistically higher [OR = 4.0 (95% CI: 1.1-14.7)] in women with HR-HPV compared to those without. Of the twelve women with ACF, subsequent histologic examination of colposcopically directed cervical biopsies confirmed CIN 1 in 4 cases (33.3%), CIN 2 in 1 case (8.3%), CIN 3 in 2 cases (16.7%), carcinoma-in-situ (CIS) in 2 cases (16.7%), and normal cervix in 3 (25.0%). Overall, the proportion of women detected with any grade of CIN was 11.5% (9/78) and 6.4% (5/78) were CIN 2 or greater lesion (CIN2+).ConclusionHIV-infected women with NCC and HR-HPV had a four-fold higher likelihood for an ACF. The practice of early colposcopic examination of HIV-infected women with prior NCC and HR-HPV may increase early detection of higher grade CIN and CIS cancer stages in our setting.

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High-risk human papillomavirus among HIV-infected women with normal cervical cytology: a pilot study in Jos, Nigeria

Cited by 13 publications

References 27 publications

Sociodemographic determinants of abnormal cervical cytology among HIV positive women in Nnewi, Nigeria

Sociodemographic determinants of abnormal cervical cytology among HIV positive women in Nnewi, Nigeria

Human Papillomavirus Laboratory Testing: the Changing Paradigm

High-risk human papilloma virus and cervical abnormalities in HIV-infected women with normal cervical cytology

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