High-risk human papilloma virus (HPV) and survival in patients with esophageal carcinoma: a pilot study

Dreilich, Martin; Bergqvist, Michael; Moberg, Martin; Brattström, Daniel; Gustavsson, Inger; Bergström, Stefan; Wanders, Alkwin; Hesselius, Patrik; Wagenius, Gunnar; Gyllensten, Ulf

doi:10.1186/1471-2407-6-94

Cited by 51 publications

(51 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…14), with HPV-16 being the most commonly detected HPV type. According to previous studies, HPV-16 has been by far the most prevalent HPV type in esophageal cancer patients globally, usually followed by HPV-18 as the second most prevalent HPV type (16,17,21,37).…”

Section: Discussionmentioning

confidence: 99%

“…Slightly higher estimates of HPV prevalence have been reported from other populations with low ESCC incidence, including Shandong (6%), Sweden (16%), and Germany (17%; refs. 15,17,21). In populations with higher ESCC incidence rates, reports of HPV prevalence in tumor tissues have ranged from 0% in Kenya and Linxian Province in China (18,35), to 54%, 65%, and 72% in Egyptian, Gansu (China), and Anyang (China) populations, respectively (15,36,37).…”

Section: Discussionmentioning

confidence: 99%

“…Although on crude analysis there was some suggestion that patients with HPV-positive tumors had longer (17,45). For SCC of the head and neck, HPV-positive tumors have been reported to have better responses to treatment and increased sensitivity to radiotherapy, leading to the suggestion that HPV infection makes the tumors more susceptible to treatment (11,46,47).…”

Section: Discussionmentioning

confidence: 99%

“…However, evidence for such an association is limited. Previous studies have shown large variations in the prevalence of HPV among patients with ESCC depending on geographic area, ethnic group, and the method used for viral detection (8,(15)(16)(17)(18)(19)(20). Even PCR-based studies using similar methodology report varying HPV DNA prevalence in human ESCC tissues (8).…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

High-Risk Human Papillomavirus in Esophageal Squamous Cell Carcinoma

Antonsson

Nancarrow

Brown

et al. 2010

Cancer Epidemiology, Biomarkers &Amp; Prevention

View full text Add to dashboard Cite

Background: Although most cases of esophageal squamous cell carcinoma (ESCC) in western populations have been attributed to high levels of exposure to tobacco and alcohol, infectious agents have been postulated as possible causes, particularly human papillomavirus (HPV).Methods: To explore this issue, we analyzed HPV DNA prevalence and HPV types together with lifestyle factors, in relation to tumor stage and survival in a low-incidence population. Archived tumor samples from a nationwide cohort of 222 ESCC patients were tested for the presence of HPV DNA by PCR; positive samples were sequenced to determine HPV type, and p16INK4a status was assessed by immunohistochemistry.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

High-Risk Human Papillomavirus in Esophageal Squamous Cell Carcinoma

Antonsson

Nancarrow

Brown

et al. 2010

Cancer Epidemiology, Biomarkers &Amp; Prevention

View full text Add to dashboard Cite

show abstract

“…The HPV family includes over 100 genotypes, 30 to 40 of which are mucosotropic, and at least 15 types of the mucosotropic HPVs have been linked to cervical cancer (5,8,10,42). In addition, some of these types are also related to other cancers of the genital tract (21,22) and to cancers of other organs (14,28). Light microscopic examination of a Papanicolaou (Pap)-stained smear is of primary importance for the detection of cervical cancer precursor lesions.…”

mentioning

confidence: 99%

Genotyping of Human Papillomaviruses by a Novel One-Step Typing Method with Multiplex PCR and Clinical Applications

Nishiwaki¹,

Yamamoto²,

Tone³

et al. 2008

J Clin Microbiol

View full text Add to dashboard Cite

We describe here a rapid, high-throughput genotyping procedure that allows the simultaneous detection of 16 high-and low-risk genital human papillomavirus (HPV) types by multiplex PCR in a single reaction tube. Multiplex PCR is based on the amplification of HPV DNA by sets of HPV genotype-specific primers, and the genotypes of HPV are visually identified by the sizes of amplicons after they are separated by capillary electrophoresis. The procedure does not include a hybridization step with HPV-specific probes and is rapid and labor-saving. We detected all 16 HPV genotypes (types 16, 58, 52, 51, 56, 31, 18, 39, 66, 59, 6, 33, 30, 35, 45, and 11) with a high sensitivity and a high degree of reproducibility. By using this newly developed method, we conducted a pilot study to examine the correlation between the prevalence and genotype distributions of HPV and the cytological group classifications for 547 cervical samples. Compared with the group of samples considered normal (14.7%), there was a significant increase in the prevalence of HPV in women with atypical squamous cells of unknown significance (61.3%), low-grade intraepithelial lesions (75.8%), and high-grade intraepithelial lesions (HSILs) (82.2%). The prevalence and distribution of type 58 were correlated with cytological malignancies, with the highest prevalence in women with HSILs. In conclusion, the novel multiplex PCR method described appears to be highly suitable not only for the screening of cervical cancer precursor lesions but also for the characterization of genotype distributions in large-scale epidemiological studies and HPV vaccination trials.Accumulating evidence indicates that persistent infection with high-risk human papillomaviruses (HPVs) is indeed a major causative factor in the development of cervical intraepithelial neoplasia and invasive cervical carcinoma (42,10,8,5,40,27,11,30). The HPV family includes over 100 genotypes, 30 to 40 of which are mucosotropic, and at least 15 types of the mucosotropic HPVs have been linked to cervical cancer (5,8,10,42). In addition, some of these types are also related to other cancers of the genital tract (21,22) and to cancers of other organs (14, 28). Light microscopic examination of a Papanicolaou (Pap)-stained smear is of primary importance for the detection of cervical cancer precursor lesions. It has been demonstrated that concomitant testing for DNA of the highrisk HPV types by the Pap test can clearly identify women at high risk for cervical cancer, particularly if persistent infection by high-risk HPV types is diagnosed (5,8,10,11,27,30,40). Furthermore, HPV genotyping is of critical importance for the investigation of the clinical behavior and the epidemiology of HPV infection, for population studies for HPV vaccination trials, and for monitoring of the efficacy of HPV vaccines. Several genotyping methods have been developed in order to identify high-risk HPV in liquid-based cytology (LBC) samples and tissue samples (1,12,34). The molecular techniques that have been applied for HPV DNA detect...

show abstract

Human papillomaviruses

2010

Infectious Causes of Cancer

View full text Add to dashboard Cite

High-risk human papilloma virus (HPV) and survival in patients with esophageal carcinoma: a pilot study

Cited by 51 publications

References 25 publications

High-Risk Human Papillomavirus in Esophageal Squamous Cell Carcinoma

High-Risk Human Papillomavirus in Esophageal Squamous Cell Carcinoma

Genotyping of Human Papillomaviruses by a Novel One-Step Typing Method with Multiplex PCR and Clinical Applications

Human papillomaviruses

Contact Info

Product

Resources

About