High-Risk Group in Node-Positive Patients with Stage IB, IIA, and IIB Cervical Carcinoma after Radical Hysterectomy and Postoperative Pelvic Irradiation

Aoki, Yoichi; Sasaki, Masaru; Watanabe, Minoru; Sato, Takaaki; Tsuneki, Ikunosuke; Aida, Hiroshi; Tanaka, Kenichi

doi:10.1006/gyno.2000.5788

Cited by 110 publications

(106 citation statements)

References 29 publications

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“…Similar to our study, some reports have shown that there is no significant difference between AC and SCC groups (Aoki et al, 2000;Ayhan et al, 2004;Chen et al 2011;Katanyoo et al, 2012). Ayhan et al found that OS and DFS were 84.0%, 87.7%, versus 83.1%, 86.4% for AC and SCC, respectively (p> 0.05) (Ayhan et al, 2004).…”

Section: Survival Outcomessupporting

confidence: 89%

“…Aoki et al analyzed patients with stage IB-IIB had positive pelvic lymph nodes and reported that no difference was detected in survival between patients with SCC and nonsquamous cell types (AC and ASC). Even after exclusion of the patients with ASC, pure AC did not have an effect on prognosis in multivariate analysis in their study (Aoki et al, 2000).…”

Section: Survival Outcomesmentioning

confidence: 75%

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Lack of any Impact of Histopathology Type on Prognosis in Patients with Early-Stage Adenocarcinoma and Squamous Cell Carcinoma of the Uterine Cervix

Teke¹,

Yöney²,

Teke³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Multivariate analysis using a Cox-proportional hazards model was used to adjust for prognostic factors and to estimate hazard ratio (HR) with 95% confidence interval (CI). Results:There was no differences between the two tumour types in age, stage, pelvic nodal metastasis, parametrial invasion, surgical margin status, DSI, LVSI, maximal tumor diameter, grade, and treatment modalities. 5-year OS and DFS were 73% and 77%, versus 64% and 69%, for SCC and adenocarcinoma, respectively (p> 0.05). Multivariate analysis revealed independent prognostic factors including pelvic nodal metastasis and resection margin status for OS (p=0.008, p=0.002, respectively). Conclusions: Prognosis of FIGO stage IA-IIB cervical cancer patients was found to be the same for those with adenocarcinoma and SCC.

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Section: Survival Outcomessupporting

confidence: 89%

Section: Survival Outcomesmentioning

confidence: 75%

Lack of any Impact of Histopathology Type on Prognosis in Patients with Early-Stage Adenocarcinoma and Squamous Cell Carcinoma of the Uterine Cervix

Teke¹,

Yöney²,

Teke³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…The number of lymph nodes involved has also been described as a risk factor for recurrence, and progressively shorter disease-free survival with increasing numbers of lymph node metastases has been noted. 17,[30][31][32][33][34] In the present sample, the recurrence risk became progressively greater with increasing numbers of metastatic pelvic lymph nodes.…”

Section: Discussionmentioning

confidence: 99%

Intensity of cervical inflammatory reaction as a risk factor for recurrence of carcinoma of the uterine cervix in stages IB and IIA

et al. 2007

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CONTEXT AND OBJECTIVE: Inflammatory reaction intensity has been indicated as a possible recurrence risk factor in carcinoma of the uterine cervix. Some authors observed greater risk with weak inflammatory reaction, while others described the opposite. This study aimed to evaluate risk factors for initial-stage uterine cervix carcinoma recurrence (IB and IIA), considering inflammatory reaction intensity. DESIGN AND SETTING: Retrospective cohort at Hospital do Câncer A. C. Camargo. METHODS: 289 patients with diagnosed uterine cervix carcinoma (stages IB and IIA) who underwent radical surgery between 1980 and 1999 were studied. Data were collected from medical records. Histological sections from tumors and lymph nodes could be reviewed in 247 cases. Five-year disease-free survival rates were calculated using the Kaplan-Meier method and curves were compared using the log-rank test. Cox's proportional-hazards model was used for multivariate analysis. Recurrence risk was estimated using hazard ratios (HR). RESULTS: Forty-three recurrences were found. Multivariate analysis identified the following independent recurrence risk factors: number of metastatic pelvic lymph nodes (one lymph node: HR = 3.3 [1.3-8.3]; two or three: HR = 5.3 [1.5-18.6]; four or more: HR = 7.6 [1.7-33.2]), tumor invasion depth (deepest third: HR = 2.1 [1.1-4.1]) and inflammatory reaction intensity in the uterine cervix (absent or slight: HR = 2.5 [1.1-5.7]). CONCLUSION: This study identified that absent or slight inflammatory reaction was an independent risk factor for recurrence. The other risk factors were the number of metastatic pelvic lymph nodes and invasion of the deepest third of the uterine cervix.

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“…In our study on stage IB-IIA cervical cancer patients, the number of positive LNs was identified as a significant prognostic factor in terms of 5-year OS rates (P=0.021). Aoki et al (15) classified positive LN patients into three groups (low, intermediate and high-risk) according to the status of parametrial invasion and the number of positive LNs. The 5-year OS rates for the intermediate-risk group were significantly lower compared with those for the low-risk group, but were significantly higher compared with those for the high-risk group.…”

Section: Discussionmentioning

confidence: 99%

Prognostic significance of positive lymph node number in early cervical cancer

Park

Bae

2016

Molecular and Clinical Oncology

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Abstract. The aim of the present study was to investigate whether the number of metastatic lymph nodes (LNs) is an independent prognostic factor for early cervical cancer. The medical records of 163 stage IB-IIA cervical cancer patients, treated with radical hysterectomy with accompanying pelvic and/or para-aortic lymphadenectomy between 1999 and 2007, were retrospectively reviewed. All prognostic factors identified as being significant in the univariate analysis were included in the multivariate analysis using the Cox proportional hazards model. Of the 156 patients included in our analysis, 27 had LN metastasis, of whom 14 patients had 1 positive node and 13 patients had ≥2 positive nodes. The 5-year overall survival (OS) and progression-free survival (PFS) rates were 92.9 and 87.2%, respectively. In terms of OS, tumour stage (P=0.002) and the number of positive LNs (P=0.021) were identified as significant prognostic factors. In terms of PFS, tumour stage (P= 0.049) was identified as a significant prognostic factor. In conclusion, the number of LN metastases is an independent risk factor for poorer survival outcomes in patients with cervical cancer.

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High-Risk Group in Node-Positive Patients with Stage IB, IIA, and IIB Cervical Carcinoma after Radical Hysterectomy and Postoperative Pelvic Irradiation

Cited by 110 publications

References 29 publications

Lack of any Impact of Histopathology Type on Prognosis in Patients with Early-Stage Adenocarcinoma and Squamous Cell Carcinoma of the Uterine Cervix

Lack of any Impact of Histopathology Type on Prognosis in Patients with Early-Stage Adenocarcinoma and Squamous Cell Carcinoma of the Uterine Cervix

Intensity of cervical inflammatory reaction as a risk factor for recurrence of carcinoma of the uterine cervix in stages IB and IIA

Prognostic significance of positive lymph node number in early cervical cancer

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