High risk for sleep apnea in the Berlin questionnaire and coronary artery disease

Martinez, Dênis; Silva, Roberto Pacheco da; Klein, Cristini; Fiori, Cíntia Zappe; Massierer, Daniela; Cassol, Cristiane Maria; Bós, Ângelo José Gonçalves; Gus, Miguel

doi:10.1007/s11325-010-0460-2

Cited by 30 publications

(13 citation statements)

References 49 publications

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“…The prevalence of a high risk of coronary artery disease associated with OSA in our survey was within these estimates. We had recently showed, in a post-hoc analysis of a smaller case-control study, that high risk for coronary artery disease associated with OSA had an odds ratio of 4.5 (1.03-19.25) for coronary artery disease 40 .…”

Section: Discussionmentioning

confidence: 99%

Obstructive sleep apnea, detected by the Berlin Questionnaire: an associated risk factor for coronary artery disease

et al. 2012

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Obstructive sleep apnea (OSA), a risk factor for coronary artery disease, remains under diagnosed. We investigated if OSA identified by the Berlin Questionnaire (BQ) is associated with the risk of coronary artery disease. Cases were patients referred for elective coronariography. The cases were classified with significant coronary lesions (stenosis > 50% in an epicardial coronary) or without significant coronary lesions. Controls were selected from a population-based sample. Positive BQ results were identified in 135 (41.2%) of 328 cases, in contrast with 151 (34.4%) of 439 control subjects (p = 0.03). In a multinomial logistic analysis, the risk for OSA identified by the BQ was independently associated with coronary artery disease in cases with lesions of at least 50% (OR = 1.53; 95%CI: 1.02-2.30; p = 0.04). The risk from OSA identified by the BQ was higher in younger subjects (40-59 years) (OR = 1.76; 95%CI: 1.05-2.97; p = 0.03) and in women (OR = 3.56; 95%CI: 1.64-7.72; p = 0.001). In conclusion, OSA identified by the BQ greatly increases the risks of coronary artery disease in patients having significant coronary artery lesions indicated by anangiogram, particularly in younger individuals and in women.

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Section: Discussionmentioning

confidence: 99%

Obstructive sleep apnea, detected by the Berlin Questionnaire: an associated risk factor for coronary artery disease

et al. 2012

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“…However, other studies using simple questions 24 or specific questionnaires to measure OSA 12,14 have also found positive associations. 25 Although some studies in Brazil used the Berlin questionnaire to evaluate the relationship between OSA and other endpoints, 11-13 only two evaluated the association of OSA defined by the Berlin questionnaire with cardiovascular events. 14,15 In a prospective cohort study of 200 individuals with ACS, Jesus et al 14 evaluated the association of OSA with cardiovascular events using a composite endpoint of cardiovascular death, recurrent CHD events, acute pulmonary edema or stroke.…”

Section: Discussionmentioning

confidence: 99%

Impact of High Risk for Obstructive Sleep Apnea on Survival after Acute Coronary Syndrome: Insights from the ERICO Registry

Maia

Goulart

Drager³

et al. 2016

Arquivos Brasileiros De Cardiologia

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BackgroundObstructive sleep apnea (OSA) is a very often clinical condition that can be associated with high mortality risk, particularly in coronary heart disease (CHD). The diagnosis of OSA is not always accessible via the gold-standard method polysomnography.ObjectiveTo evaluate long-term influence of the high risk for OSA on fatal and non-fatal outcomes after acute coronary syndrome (ACS) in the Acute Coronary Syndrome Registry Strategy (ERICO) Study using the Berlin questionnaire as a surrogate.MethodsBerlin questionnaire, a screening questionnaire for OSA, was applied in 639 cases of ACS 30 days after the index event. Cox regression proportional-hazards model was used to calculate the hazard ratio (HR) of all-cause, cardiovascular and CHD (myocardial infarction) mortality, as well as, the combined endpoint of fatal or recurrent non-fatal CHD.ResultsThe high-risk group for OSA had higher frequencies of previous personal/family history of CHD and diabetes, in addition to a poorer event-free survival, as compared to the low-risk group (p-log-rank=0.03). The HR for fatal or recurrent non-fatal CHD was 4.26 (95% confidence interval, 1.18 - 15.36) in patients at high risk for OSA compared to those at low risk for OSA after a 2.6-year mean follow-up.ConclusionsUsing Berlin questionnaire, we were able to identify high risk for OSA as an independent predictor of non-fatal reinfarction or CHD mortality in post-ACS individuals in a long-term follow-up.

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“…Indeed, certain reports have correlated OSA with an increased occurrence of traffic accidents . In the United States, approximately 20 million adults have been diagnosed with OSA , indicating that OSA is a major public health problem . Discerning the significance of snoring, therefore, is helpful in identifying patients with undiagnosed OSA or at risk of developing the disease.…”

Section: Discussionmentioning

confidence: 99%

Vibration signals of snoring as a simple severity predictor for obstructive sleep apnea

Pan

Liu

et al. 2014

Clinical Respiratory J

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High risk for sleep apnea in the Berlin questionnaire and coronary artery disease

Abstract: In conclusion, simple questionnaire-based diagnostic tools can be included in the screening procedures of patients with angina to detect the need for further OSA evaluation. In conclusion, the BQ is an effective instrument for this purpose.

Cited by 30 publications

References 49 publications

Obstructive sleep apnea, detected by the Berlin Questionnaire: an associated risk factor for coronary artery disease

Obstructive sleep apnea, detected by the Berlin Questionnaire: an associated risk factor for coronary artery disease

Impact of High Risk for Obstructive Sleep Apnea on Survival after Acute Coronary Syndrome: Insights from the ERICO Registry

Vibration signals of snoring as a simple severity predictor for obstructive sleep apnea

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