High Risk Factors Associated With Early Childhood Hearing Loss: A 3-Year Review

Dumanch, Kelsey A.; Holte, Lenore; O’Hollearn, Tammy; Walker, Elizabeth; Clark, Jacob A.; Oleson, Jacob

doi:10.1044/2017_aja-16-0116

Cited by 25 publications

(43 citation statements)

References 36 publications

(38 reference statements)

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“…Categorical data including NICU care, ventilator dependence, oxygen requirement of any kind, aminoglycoside exposure, and family history demonstrated statistical significance for hearing loss compared to the control cohort. While other studies have demonstrated associated risks between hearing loss and younger gestational age and birth weights, our study variables showed only small effect size between groups (Beswick et al, 2012;van Dommelen et al, 2015;Dumanch et al, 2017). This may be due to patient stratification schemes in prior studies using birth weight (low, very low, etc.)…”

Section: Discussioncontrasting

confidence: 75%

Medical Referral Patterns and Etiologies for Children With Mild-to-Severe Hearing Loss

et al. 2018

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Objectives: 1) Identify the etiologies and risk factors of the patient cohort and determine the degree to which they reflected the incidence for children with hearing loss and 2) quantify practice management patterns in three catchment areas of the United States with available centers of excellence in pediatric hearing loss Design: Medical information for 307 children with bilateral, mild to severe hearing loss was examined retrospectively. Children were participants in the Outcomes of Children with Hearing Loss (OCHL) study, a five-year longitudinal study that recruited subjects at three different sites. Children aged 6 months to 7 years at time of OCHL enrollment were participants in this study. Children with cochlear implants, children with severe or profound hearing loss, and children with significant cognitive or motor delays were excluded from the OCHL study and, by extension, from this analysis. Medical information was gathered using medical records and participant intake forms, the latter reflecting a caregiver's report. A comparison group included 134 children with normal hearing. A chi-square test on two-way tables was used to assess for differences in referral patterns by site for the children who are hard of hearing (CHH). Linear regression was performed on gestational age and birth weight as continuous variables. Risk factors were assessed using ttests. The alpha value was set at p < 0.05.Results: Neonatal intensive care unit stay, mechanical ventilation, oxygen requirement, aminoglycoside exposure, and family history were correlated with hearing loss. For this study cohort, congenital cytomegalovirus (CMV), strep positivity, bacterial meningitis, extracorporeal

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Section: Discussioncontrasting

confidence: 75%

Medical Referral Patterns and Etiologies for Children With Mild-to-Severe Hearing Loss

et al. 2018

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“…Although there is good evidence that some risk factors are associated with hearing loss (Dumanch et al, 2017), investigators have questioned the utility of other risk factors included in screening or surveillance programs because of the low yield of late-onset PCHL (Wood et al, 2013) and changes in standards of care (Beswick et al, 2012;Beswick et al, 2013;Lü et al, 2011;O'Connor et al, 2013). Surveillance programs are costly for both the health system and parents (The Joint Committee on Infant Hearing, 2019); therefore, updating knowledge on risk factors for PCHL is warranted.…”

Section: Introductionmentioning

confidence: 99%

Cytomegalovirus—A Risk Factor for Childhood Hearing Loss: A Systematic Review

et al. 2021

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Context: Permanent hearing loss is an important public health issue in children with consequences for language, social, and academic functioning. Early hearing detection, intervention, and monitoring are important in mitigating the impact of permanent childhood hearing loss. Congenital cytomegalovirus (CMV) infection is a leading cause of hearing loss.Objective: To synthesize the evidence on the association between CMV infection and permanent childhood hearing loss. Design:We performed a systematic review and examined scientific literature from the following databases: MEDLINE, Ovid MEDLINE(R) Daily and Ovid MEDLINE(R), Embase, and CINAHL. The primary outcome was permanent bilateral or unilateral hearing loss with congenital onset or onset during childhood (birth to 18 years). The secondary outcome was progressive hearing loss. We included studies reporting data on CMV infection. Randomized controlled trials, quasiexperimental studies, nonrandomized comparative non-comparative studies, and case series were considered. Data were extracted and the quality of individual studies was assessed with the Qualitative Assessment Tool for Quantitative Studies (McMaster University). The quality and strength of the evidence were graded using the Grading of Recommendations Assessment, Development and Evaluation (GRADE). A narrative synthesis was completed.Results: Sixty-five articles were included in the review. Prevalence of hearing loss at birth was over 33% among symptomatic CMV-infected newborns, and less than 15% in asymptomatic infections. This difference in prevalence was maintained during childhood with more than 40% prevalence reported for symptomatic and less than 30% for asymptomatic CMV. Late-onset and 2 progressive hearing loss appear to be characteristic of congenital CMV infections. Definitions of hearing loss, degree of loss and reporting of laterality varied across studies. All degrees and both bilateral and unilateral loss were reported, regardless of symptomatic and asymptomatic status at birth and no conclusions about the characteristics of hearing loss could be drawn.Various patterns of hearing loss were reported including stable, progressive, and fluctuating, and improvement in hearing (sometimes to normal hearing) was documented. These changes were reported in children with symptomatic/asymptomatic congenital CMV infection, presenting with congenital/early onset/late-onset hearing loss and in children treated and untreated with antiviral medication.Conclusions: Symptomatic and asymptomatic congenital CMV infection should be considered a risk factor for hearing loss at birth and during childhood, and for progressive hearing loss.Therefore, CMV should be included as a risk factor in screening and surveillance programs and be taken into account in clinical follow-up of children with hearing loss.

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“…11,14 Syndromes associated with hearing loss and craniofacial anomalies are strongly predictive of postnatal hearing loss, with craniofacial anomalies inversely related to the risk of progressive hearing loss. 15,16 The prevalence of JCIH risk factors in children with UHL or BHL has been studied independently. 12,17 To our knowledge, no studies have compared JCIH risk factors among groups of children with UHL or BHL.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

An Analysis of Risk Factors in Unilateral Versus Bilateral Hearing Loss

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Appelbaum

Armstrong

et al. 2019

Ear, Nose & Throat Journal

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A retrospective review of children with confirmed hearing loss identified through universal newborn hearing screening (UNHS) in Virginia from 2010 to 2014 was conducted in order to compare the incidence of Joint Committee on Infant Hearing (JCIH) risk factors in children with unilateral hearing loss (UHL) to bilateral hearing loss (BHL). Over the 5-year study period, 1004 children (0.20% of all births) developed a confirmed hearing loss, with 544 (51%) children having at least one JCIH risk factor. Overall, 18% of children with confirmed hearing loss initially passed UNHS. Of all children with risk factors, 226 (42%) demonstrated UHL and 318 (58%) had BHL. The most common risk factors for UHL were neonatal indicators (69%), craniofacial anomalies (30%), stigmata of HL syndromes (14%), and family history (14%). The most common risk factors in BHL were neonatal indicators (49%), family history (27%), stigmata of HL syndromes (19%), and craniofacial anomalies (16%). Children with the risk factor for positive family history were more likely to have BHL, while those with craniofacial anomalies were more likely to have UHL ( P < .001). Neonatal indicators were the most commonly identified risk factor in both UHL and BHL populations. Children with UHL were significantly more likely to have craniofacial anomalies, while children with BHL were more likely to have a family history of hearing loss. Further studies assessing the etiology underlying the hearing loss and risk factor associations are warranted.

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High Risk Factors Associated With Early Childhood Hearing Loss: A 3-Year Review

Abstract: Certain risk factors place a child at significantly greater risk of congenital hearing impairment or developing permanent hearing loss by age 3. Follow-up diagnostic testing should remain a priority for children with certain risk factors for hearing loss.

Cited by 25 publications

References 36 publications

Medical Referral Patterns and Etiologies for Children With Mild-to-Severe Hearing Loss

Medical Referral Patterns and Etiologies for Children With Mild-to-Severe Hearing Loss

Cytomegalovirus—A Risk Factor for Childhood Hearing Loss: A Systematic Review

An Analysis of Risk Factors in Unilateral Versus Bilateral Hearing Loss

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