High-risk cervical epithelial neoplasia grade 1 treated by loop electrosurgical excision: follow-up and value of HPV testing

Alonso, Immaculada; Torné, Aureli; Puig, L.; Esteve, Roser; Quintò, Llorenç; García, Sonia; Campo, Elı́as; Pahisa, Jaume; Ordi, Jaume

doi:10.1016/j.ajog.2007.01.023

Cited by 25 publications

(23 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Using semiquantitative or quantitative HPV DNA tests, several observational studies have found that high viral load correlates with high-grade lesions. [30][31][32][33] In contrast, there are no differences in this study between HR-HPV (types 16, 18, 52, 58, 31 and 33) loads and severity of cervical lesions observed in other studies. 5,34 Another issue concerning viral load is that until now, the measurement of viral load has not been justified in clinical settings due to the wide variations in viral load within disease grades and the fact that most studies have been limited to measuring HPV 16 viral load only.…”

Section: Discussioncontrasting

confidence: 98%

Type‐specific human papillomavirus oncogene messenger RNA levels correlate with the severity of cervical neoplasia

Lee²,

Chang

et al. 2010

Intl Journal of Cancer

View full text Add to dashboard Cite

This study aimed to evaluate whether quantitation of high-risk human papillomavirus (HR-HPV) E6 messenger RNA (mRNA) can be a potential biomarker for detecting the severity of cervical lesions. HPV genotyping was performed using a modified MY11/ GP61 PCR for HPV DNA amplification, followed by HPV genotype-specific hybridization with on a gene chip. E6 type-specific PCR was used to validate multiple infections. Quantitative real-time reverse transcriptase (QRT-PCR) and real-time PCR used to measure mRNA levels and DNA viral loads of 6 HPV oncogenic types (HPV 16,18,31,33, 52 and 58) in 720 liquid-based cytology samples. The HPV DNA and RNA measurements were correlated with cervical lesions diagnosed by histopathologic examination. mRNA transcripts in the 6 types HPV DNA-positive cases was lower in normal women and

show abstract

Section: Discussioncontrasting

confidence: 98%

Type‐specific human papillomavirus oncogene messenger RNA levels correlate with the severity of cervical neoplasia

Lee²,

Chang

et al. 2010

Intl Journal of Cancer

View full text Add to dashboard Cite

show abstract

“…20 Recently, it has been suggested that pre-conization HR-HPV Ն 100 RLU had an increased rate of persistent HR-HPV infection and disease recurrence. [21][22][23] Furthermore, we found post-treatment HR-HPV Ն 100 RLU showed an increased risk of disease recurrence.…”

Section: Discussionmentioning

confidence: 73%

“…Meanwhile, high concentrations of HPV DNA in cervical specimens (HPV load) has been evaluated as a marker for the presence of CIN 20 . Recently, it has been suggested that pre‐conization HR‐HPV ≥ 100 RLU had an increased rate of persistent HR‐HPV infection and disease recurrence 21–23 . Furthermore, we found post‐treatment HR‐HPV ≥ 100 RLU showed an increased risk of disease recurrence.…”

Section: Discussionmentioning

confidence: 78%

High‐risk human papillomavirus testing for monitoring patients treated for high‐grade cervical intraepithelial neoplasia

Jeong

Lee

Kim

et al. 2009

J of Obstet and Gynaecol

View full text Add to dashboard Cite

show abstract

“…For CIN, the effect of alcohol consumption was examined for CIN1 and CIN2/3 subgroups respectively [8], [11]–[13]. HPV viral load was categorized into three groups: high (≥100 RLU/PC), medium (10–100 RLU/PC), and low (<10 RLU/PC) [14]–[17].…”

Section: Methodsmentioning

confidence: 99%

Alcohol Consumption and Viral Load Are Synergistically Associated with CIN1

Min

Lee

et al. 2013

PLoS ONE

View full text Add to dashboard Cite

PurposeWe investigated the association between alcohol consumption and risk of cervical intraepithelial neoplasia (CIN) and cervical cancer, and determined whether these associations were modified by human papillomavirus (HPV) viral load in high-risk HPV-positive women participating in the Korean HPV cohort study (KHPV).MethodsAmong the women recruited in the KHPV (n = 1,243) from March 2006 to December 2009, we analyzed normal cytology (n = 581) as control group, CIN1 (n = 299), CIN2/3 (n = 161), or cervical cancer (n = 202). Multinomial logistic analysis was performed to estimate multivariate-adjusted odds ratios (OR).ResultsAlcohol drinkers had an increased risk of CIN1 (OR = 2.18, 95% CI 1.22–3.89) compared with non-drinkers after adjusting for potential confounders. Subjects with more frequent alcohol consumption had a higher risk of CIN1 (p for linear trend <0.0001). Higher ethanol consumption was associated with an increased risk of CIN1 (p for linear trend = 0.0001). We also observed a synergistic effect between HPV viral load and alcohol consumption: drinkers with a high HPV viral load (≥100 RLU/PC) were associated with a significantly increased risk of CIN1 (OR = 19.1; 95% CI, 6.60–55.3, interaction p<0.001). There were no associations between alcohol drinking and CIN2/3 or cervical cancer.ConclusionsHPV viral load and alcohol was associated with the risk of CIN1 among high-risk HPV-positive women. This is the first demonstration that alcohol is an independent and combined risk factor of CIN1.

show abstract

High-risk cervical epithelial neoplasia grade 1 treated by loop electrosurgical excision: follow-up and value of HPV testing

Cited by 25 publications

References 22 publications

Type‐specific human papillomavirus oncogene messenger RNA levels correlate with the severity of cervical neoplasia

Type‐specific human papillomavirus oncogene messenger RNA levels correlate with the severity of cervical neoplasia

High‐risk human papillomavirus testing for monitoring patients treated for high‐grade cervical intraepithelial neoplasia

Alcohol Consumption and Viral Load Are Synergistically Associated with CIN1

Contact Info

Product

Resources

About