High-Risk Breast Lesions at Imaging-Guided Needle Biopsy: Usefulness of MRI for Treatment Decision

Londero, Viviana; Zuiani, Chiara; Linda, Anna; Girometti, Rossano; Bazzocchi, Massimo; Sardanelli, Francesco

doi:10.2214/ajr.11.7869

Cited by 49 publications

(37 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…As a consequence, CE-MRI has been recommended for a spectrum of indications by medical bodies such as the American College of Radiology (10), the European Society of Breast Imaging (11, 12), and the European Society of Breast Cancer Specialists (EUSOMA) (13). The debate is still open on preoperative MRI (14, 15), but new indications, such as nipple discharge (16, 17) and evaluation of lesions with uncertain malignant potential (so-called B3 lesions), are emerging (18). …”

Section: Introductionmentioning

confidence: 99%

Clinical Breast MR Using MRS or DWI: Who Is the Winner?

et al. 2016

Self Cite

View full text Add to dashboard Cite

Magnetic resonance imaging (MRI) of the breast gained a role in clinical practice thanks to the optimal sensitivity of contrast-enhanced (CE) protocols. This approach, first proposed 30 years ago and further developed as bilateral highly spatially resolved dynamic study, is currently considered superior for cancer detection to any other technique. However, other directions than CE imaging have been explored. Apart from morphologic features on unenhanced T2-weighted images, two different non-contrast molecular approaches were mainly run in vivo: proton MR spectroscopy (1H-MRS) and diffusion-weighted imaging (DWI). Both approaches have shown aspects of breast cancer (BC) hidden to CE-MRI: 1H-MRS allowed for evaluating the total choline peak (tCho) as a biomarker of malignancy; DWI showed that restricted diffusivity is correlated with high cellularity and tumor aggressiveness. Secondary evidence on the two approaches is now available from systematic reviews and meta-analyses, mainly considered in this article: pooled sensitivity ranged 71–74% for 1H-MRS and 84–91% for DWI; specificity 78–88% and 75–84%, respectively. Interesting research perspectives are opened for both techniques, including multivoxel MRS and statistical strategies for classification of MR spectra as well as diffusion tensor imaging and intravoxel incoherent motion for DWI. However, when looking at a clinical perspective, while MRS remained a research tool with important limitations, such as relatively long acquisition times, frequent low quality spectra, difficult standardization, and quantification of tCho tissue concentration, DWI has been integrated in the standard clinical protocols of breast MRI and several studies showed its potential value as a stand-alone approach for BC detection.

show abstract

Section: Introductionmentioning

confidence: 99%

Clinical Breast MR Using MRS or DWI: Who Is the Winner?

et al. 2016

Self Cite

View full text Add to dashboard Cite

show abstract

“…However, data on high-risk lesions from MRI-guided biopsies, including ADH, ALH, flat epithelial atypia (FEA), and LCIS are limited. [6][7][8][9][10] The purpose of our study was to determine the frequency of high-risk histopathologic features resulting from MRI-guided core needle biopsy, the subsequent upstage rates to malignancy, and whether the imaging characteristics could help predict upstage rates.…”

Section: Introductionmentioning

confidence: 99%

Magnetic Resonance Imaging-Guided Core Needle Breast Biopsies Resulting in High-Risk Histopathologic Findings: Upstage Frequency and Lesion Characteristics

Weinfurtner

Patel

Laronga

et al. 2015

Clinical Breast Cancer

View full text Add to dashboard Cite

“…Londero ve ark. [65] 227 olguluk çalışmalarında ise, MRG'de kontrast tutan yüksek risk lezyonların %18'inde malignite saptarken, kontrast tutmayan lezyonlarda bu oranı %3 bulmuşlardır.…”

Section: Yüksek Risk Lezyonlarda Mrgunclassified

Radyolojik-Patolojik Korelasyon: Yüksek Risk Lezyonlarda Ne Yapmalıyız?

Oktay¹

2014

Trd Sem

View full text Add to dashboard Cite

High-Risk Breast Lesions at Imaging-Guided Needle Biopsy: Usefulness of MRI for Treatment Decision

Abstract: The absence of enhancement at dynamic MRI allowed reliable exclusion of invasive cancers among high-risk lesions diagnosed at needle biopsy.

Cited by 49 publications

References 42 publications

Clinical Breast MR Using MRS or DWI: Who Is the Winner?

Clinical Breast MR Using MRS or DWI: Who Is the Winner?

Magnetic Resonance Imaging-Guided Core Needle Breast Biopsies Resulting in High-Risk Histopathologic Findings: Upstage Frequency and Lesion Characteristics

Radyolojik-Patolojik Korelasyon: Yüksek Risk Lezyonlarda Ne Yapmalıyız?

Contact Info

Product

Resources

About