High retinoic acid receptor-related orphan receptor A gene expression in peripheral blood leukocytes may be related to acute myocardial infarction

Meng, Heyu; Ruan, Jianjun; Tian, Xiaomin; Li, Lihong; Chen, Weiwei; Meng, F.

doi:10.1177/03000605211019663

Cited by 6 publications

(6 citation statements)

References 38 publications

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“…Interleukin-1β (IL-1β), Interleukin-6 (IL-6), tumor necrosis factor α (TNF-α), and leptin are examples of proinflammatory adipokines produced by adipose tissue during this process, while anti-inflammatory adipokines such adiponectin are decreased [24]. These processes are thought to play a part in the development of atherosclerosis, which has also been supported by our earlier research [24][25][26][27].…”

Section: Introductionmentioning

confidence: 62%

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Trace Elements Open a New Direction for the Diagnosis of Atherosclerosis

Meng¹,

Ruan²,

Chen³

et al. 2023

Rev. Cardiovasc. Med.

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Abnormal or excessive accumulation of adipose tissue leads to a condition called obesity. Long-term positive energy balance arises when energy intake surpasses energy expenditure, which increases the risk of metabolic and other chronic diseases, such as atherosclerosis. In industrialized countries, the prevalence of coronary heart disease is positively correlated with the human development index. Atherosclerotic cardiovascular disease (ACD) is among the primary causes of death on a global scale. There is evidence to support the notion that individuals from varied socioeconomic origins may experience varying mortality effects as a result of high blood pressure, high blood sugar, raised cholesterol levels, and high body mass index (BMI). However, it is believed that changes in the concentration of trace elements in the human body are the main contributors to the development of some diseases and the transition from a healthy to a diseased state. Metal trace elements, non-metal trace elements, and the sampling site will be examined to determine whether trace elements can aid in the diagnosis of atherosclerosis. This article will discuss whether trace elements, discussed under three sections of metal trace elements, non-metal trace elements, and the sampling site, can participate in the diagnosis of atherosclerosis.

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Section: Introductionmentioning

confidence: 62%

“…Peripheral blood can be used as a window to evaluate diseases [48][49][50]. It is convenient for sampling and causes minimal harm [51].…”

Section: Peripheral Bloodmentioning

confidence: 99%

Trace Elements Open a New Direction for the Diagnosis of Atherosclerosis

Meng¹,

Ruan²,

Chen³

et al. 2023

Rev. Cardiovasc. Med.

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“…With respect to translational approaches, the REVERB agonist SR9009 when given early after ischemia, in mice, improved ischemia-perfusion-related remodeling and cardiac function ( Reitz et al, 2019 ). In addition to REVERB agonists, attention is currently being applied to the development of RORa ligands for cardiovascular disease, for example, they are overexpressed in acute myocardial infarction ( Meng et al, 2021 ).…”

Section: Circadian Disruption In Vascular Diseasementioning

confidence: 99%

The Role of Circadian Clock Genes in Critical Illness: The Potential Role of Translational Clock Gene Therapies for Targeting Inflammation, Mitochondrial Function, and Muscle Mass in Intensive Care

Ray

2022

J Biol Rhythms

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The Earth’s 24-h planetary rotation, with predictable light and heat cycles, has driven profound evolutionary adaptation, with prominent impacts on physiological mechanisms important for surviving critical illness. Pathways of interest include inflammation, mitochondrial function, energy metabolism, hypoxic signaling, apoptosis, and defenses against reactive oxygen species. Regulation of these by the cellular circadian clock (BMAL-1 and its network) has an important influence on pulmonary inflammation; ventilator-associated lung injury; septic shock; brain injury, including vasospasm; and overall mortality in both animals and humans. Whether it is cytokines, the inflammasome, or mitochondrial biogenesis, circadian medicine represents exciting opportunities for translational therapy in intensive care, which is currently lacking. Circadian medicine also represents a link to metabolic determinants of outcome, such as diabetes and cardiovascular disease. More than ever, we are appreciating the problem of circadian desynchrony in intensive care. This review explores the rationale and evidence for the importance of the circadian clock in surviving critical illness.

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“…For instance, high ADAMTS4 expression in peripheral plasma and mononuclear cells is a key factor aggravating the instability of atherosclerotic plaques [13], and an increase in interleukin-32 expression in peripheral plasma could play a role in the development of AMI from SCAD [14]. Elevated RORA and ABCB1 in leukocytes may be other suitable molecular indicators for the early diagnosis of AMI [15,16]. Thrombospondin 3 (THBS3) was originally discovered during DNA sequencing upstream of the transcription start site of the mouse Muc1 (episialin) gene [17], a member of the THBS family that mediates cell-cell and cell-matrix interaction.…”

Section: Introductionmentioning

confidence: 99%

Correlation Between Low THBS3 Expression in Peripheral Blood and Acute Myocardial Infarction

Chen¹,

Meng²,

Meng³

et al. 2022

Front. Biosci. (Landmark Ed)

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Background: Thrombospondin (THBS) 3 is an adhesive glycoprotein involved in cell-cell and cell-matrix interactions. The purpose of this study is to determine whether THBS3 expression in peripheral blood can be used as a biomarker to predict the risk of acute myocardial infarction (AMI). Methods: The peripheral blood of 111 patients with stable coronary artery disease (SCAD) and 112 patients with AMI was obtained. The experimental and the control cohorts were the AMI and SCAD groups, respectively. The expression of THBS3 mRNA and protein in both groups was determined using reverse-transcription polymerase chain reaction and enzyme-linked immunosorbent assay. Results: THBS3 expression (range) in the peripheral plasma of patients in the AMI group was lower than that of patients in the SCAD group (4.526 (3.748-5.521), 5.511 (4.726-6.334), respectively), which was 0.82 times lower than the control (p < 0.001). Furthermore, THBS3 mRNA level in the peripheral blood mononuclear cells of patients with AMI was 0.47 times lower than that in patients with SCAD (p < 0.05). AMI was associated with fasting blood glucose levels, platelet counts and low THBS3 expression. Logistic regression analysis revealed that decreased expression of THBS3 protein increased the probability of AMI by 4.076 times (p < 0.01). Additionally, high fasting blood glucose and high platelet counts increased the risk of AMI by 2.819 and 6.515 times, respectively (p < 0.05). Conclusions: THBS3 mRNA and protein levels in the peripheral blood of patients in the AMI group were much lower compared with those of patients in the SCAD group. Low THBS3 expression in peripheral blood was related to AMI and was an independent risk factor for AMI. Thus, low THBS3 expression in peripheral blood may be a novel, suitable molecular marker for the early detection of AMI.

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High retinoic acid receptor-related orphan receptor A gene expression in peripheral blood leukocytes may be related to acute myocardial infarction

Cited by 6 publications

References 38 publications

Trace Elements Open a New Direction for the Diagnosis of Atherosclerosis

Trace Elements Open a New Direction for the Diagnosis of Atherosclerosis

The Role of Circadian Clock Genes in Critical Illness: The Potential Role of Translational Clock Gene Therapies for Targeting Inflammation, Mitochondrial Function, and Muscle Mass in Intensive Care

Correlation Between Low THBS3 Expression in Peripheral Blood and Acute Myocardial Infarction

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