“…53,54 In this scenario, intracranial high-resolution vessel wall MRI has the advantage to show wall inflammation of the proximal vessels before changes in vessel caliber appear. [55][56][57] The vessel wall may show nodular or smooth enhancement, with or without stenosis. Intracranial vessel wall enhancement is more common than brain infarction in patients with TBM, and this technique has demonstrated that cerebral artery involvement is more common and extensive than previously thought.…”
Section: Ademmentioning
confidence: 99%
“…Conventional catheter angiographic triad of TBM typically demonstrates a hydrocephalic pattern that includes narrowing of the arteries at the base of the brain and narrowing or occlusion of the small or medium‐sized arteries with early draining veins 53,54 . In this scenario, intracranial high‐resolution vessel wall MRI has the advantage to show wall inflammation of the proximal vessels before changes in vessel caliber appear 55–57 . The vessel wall may show nodular or smooth enhancement, with or without stenosis.…”
Section: Specific Issues When Diagnosing Cns Tb and The Role Of Mrimentioning
Neurotuberculosis is defined as a tuberculous infection of the meninges, brain parenchyma, vessels, cranial and spinal nerves, spinal cord, skull, and spine that can occur either in a localized or in a diffuse form.It is a heterogeneous disease characterized by many imaging appearances and it has been defined as “the great mimicker” due to similarities with many other conditions.The diagnosis of central nervous system (CNS) tuberculosis (TB) is based on clinical presentation, neuroimaging findings, laboratory and microbiological findings, and comprehensive evaluation of the response to anti‐TB drug treatment.However, the absence of specific symptoms, the wide spectrum of neurological manifestations, the myriad of imaging findings, possible inconclusive laboratory results, and the paradoxical reaction to treatment make the diagnosis often challenging and difficult, potentially delaying adequate treatment with possible devastating short‐term and long‐term neurologic sequelae.Familiarity with the imaging characteristics helps in accurate diagnosis and may prevent or limit significantly morbidity and mortality. The goal of this review is to provide a comprehensive up‐to‐date overview of the conventional and advanced imaging features of CNS TB for radiologists, neuroradiologists, and pediatric radiologists. We discuss the most typical neurotuberculosis imaging findings and their differential diagnosis in children and adults with the goal to provide a global overview of this entity.
“…53,54 In this scenario, intracranial high-resolution vessel wall MRI has the advantage to show wall inflammation of the proximal vessels before changes in vessel caliber appear. [55][56][57] The vessel wall may show nodular or smooth enhancement, with or without stenosis. Intracranial vessel wall enhancement is more common than brain infarction in patients with TBM, and this technique has demonstrated that cerebral artery involvement is more common and extensive than previously thought.…”
Section: Ademmentioning
confidence: 99%
“…Conventional catheter angiographic triad of TBM typically demonstrates a hydrocephalic pattern that includes narrowing of the arteries at the base of the brain and narrowing or occlusion of the small or medium‐sized arteries with early draining veins 53,54 . In this scenario, intracranial high‐resolution vessel wall MRI has the advantage to show wall inflammation of the proximal vessels before changes in vessel caliber appear 55–57 . The vessel wall may show nodular or smooth enhancement, with or without stenosis.…”
Section: Specific Issues When Diagnosing Cns Tb and The Role Of Mrimentioning
Neurotuberculosis is defined as a tuberculous infection of the meninges, brain parenchyma, vessels, cranial and spinal nerves, spinal cord, skull, and spine that can occur either in a localized or in a diffuse form.It is a heterogeneous disease characterized by many imaging appearances and it has been defined as “the great mimicker” due to similarities with many other conditions.The diagnosis of central nervous system (CNS) tuberculosis (TB) is based on clinical presentation, neuroimaging findings, laboratory and microbiological findings, and comprehensive evaluation of the response to anti‐TB drug treatment.However, the absence of specific symptoms, the wide spectrum of neurological manifestations, the myriad of imaging findings, possible inconclusive laboratory results, and the paradoxical reaction to treatment make the diagnosis often challenging and difficult, potentially delaying adequate treatment with possible devastating short‐term and long‐term neurologic sequelae.Familiarity with the imaging characteristics helps in accurate diagnosis and may prevent or limit significantly morbidity and mortality. The goal of this review is to provide a comprehensive up‐to‐date overview of the conventional and advanced imaging features of CNS TB for radiologists, neuroradiologists, and pediatric radiologists. We discuss the most typical neurotuberculosis imaging findings and their differential diagnosis in children and adults with the goal to provide a global overview of this entity.
“…Recently, highresolution vessel wall imaging (HR-VWI) has proven useful to differentiate ischemic lesions from vessel wall inflammation associated with infectious vasculitis, and HR-VWI sequences can depict cranial nerve enhancement in infectious conditions, as demonstrated by Feitoza et al. ( 5 , 6 ) and illustrated in Figure 4 .…”
The cranial nerves, which represent extensions of the functional structures of the brain, traverse the head and neck. They are connected to various cranial structures and are associated with several diseases. An in-depth understanding of their complex anatomy and normal imaging appearance allows the examiner to identify and characterize abnormalities with greater precision. One important tool for evaluating the cranial nerves is contrast-enhanced magnetic resonance imaging, especially that employing three-dimensional steady-state free precession sequences, which provide high soft-tissue and spatial resolution, despite the slen-derness of the nerves. In most cases of cranial nerve abnormalities, the imaging findings are nonspecific. Therefore, to narrow the differential diagnosis, it is necessary to take a full patient history, perform a focused physical examination, and order laboratory tests. In this pictorial essay, we review, illustrate, and discuss, from a pathophysiological perspective, infectious, neoplastic, and demyelinating disorders, as well as other inflammatory disorders, affecting the cranial nerves, the aim being to provide a practical, tangible reference for radiologists to use in daily practice.
“…The findings contribute to the pathophysiology of the disease, by demonstrating concentric and irregular wall enhancement (vasculitis). The degree of vessel involvement correlates with the severity of disease stage, 1 and was demonstrated in other infections, such as syphilis, 4 and tuberculosis, 1 5 but not in neurocysticercosis.…”
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