High-Resolution Ultrasound Imaging to Demonstrate and Predict Efficacy of Carbon Dioxide Fractional Resurfacing Laser Treatment

Naouri, M.; Atlan, Mickael; Perrodeau, Élodie; Georgesco, Gabriella; Khallouf, R.; Martin, Ludovic; Machet, L.

doi:10.1111/j.1524-4725.2011.01943.x

Cited by 35 publications

(32 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…5). 12 The PXE echostructure was also different from other connective tissue diseases studied with HFUS, and could be used for differential diagnosis in ambiguous cases. Several publications have stated that dermal thickness in classical and hypermobile forms of Ehlers-Danlos syndrome is reduced 18–20 although dermal echogenicity is homogeneous.…”

Section: Discussionmentioning

confidence: 98%

High-frequency (20-50 MHz) ultrasonography of pseudoxanthoma elasticum skin lesions

et al. 2013

View full text Add to dashboard Cite

Summary Background In most patients pseudoxanthoma elasticum (PXE) manifests with yellowish cutaneous papules and dermal elastorrhexis on skin biopsy. However, in a small number of cases there are no skin manifestations on clinical examination. To establish a diagnosis of PXE in such patients with limited manifestations such as angioid streaks and/or premature cardiovascular disease is challenging. It would therefore be valuable to predict the skin areas that would yield a biopsy specimen positive for elastorrhexis with a non-invasive procedure. High frequency ultrasonography (HFUS) should be evaluated in this respect. Objectives Prior to achieve the goal mentioned above we aimed at describing the characteristics of clinically visible PXE skin using HFUS, and to evaluate its relevance for diagnosis. Methods HFUS was performed in a cohort of PXE patients and controls at a referral centre. HFUS images of PXE skin were compared to those of other conditions. Five operators were tasked with the blind scoring of multiple HFUS images of photoprotected or photoexposed skin from patients with PXE and controls. The diagnostic relevance indices (sensitivity, specificity, likelihood ratios, inter-observer agreement) were calculated. Results The HFUS changes considered as diagnostic for PXE were primarily oval homogeneous hypoechogenic areas in the middermis. The size of these areas closely matched the extent of the histological changes. The sensitivity and specificity of the diagnostic items and inter-observer agreement were high, particularly in photoprotected skin. Dermal hypoechogenicity in PXE could be related to high hydration of connective tissue due to the presence of glycosaminoglycans despite elastic fibre mineralization. Conclusions HFUS provides suggestive images of PXE skin lesions. HFUS should be now studied to determine if it is a potentially valuable technique for the non-invasive identification of elastorrhexis in PXE patients in whom skin involvement is clinically minimal or absent.

show abstract

Section: Discussionmentioning

confidence: 98%

High-frequency (20-50 MHz) ultrasonography of pseudoxanthoma elasticum skin lesions

et al. 2013

View full text Add to dashboard Cite

show abstract

“…According to a recent study, the treatment appears to be more effective in younger patients with thin skin. 17 However, no predictive factors could be identified before the treatment. These individuals might have needed higher treatment settings.…”

Section: Discussionmentioning

confidence: 99%

Efficacy and safety of a single treatment using a 10,600-nm carbon dioxide fractional laser for mild-to-moderate atrophic acne scars in Asian skin

Hsiao

Lin

Huang

et al. 2013

Dermatologica Sinica

View full text Add to dashboard Cite

“…33-34 Nevertheless, in contrast with this study's findings, many clinical trials with fractional lasers concur that pre-treatment topical anesthetics are sufficient to perform the procedure. 35-37 …”

Section: Discussionmentioning

confidence: 99%

Fractional Erbium laser in the treatment of photoaging: randomized comparative, clinical and histopathological study of ablative (2940nm) vs. non-ablative (1540nm) methods after 3 months

Borges

Cuzzi

Mandarim-de-Lacerda

et al. 2014

An. Bras. Dermatol.

View full text Add to dashboard Cite

BACKGROUNDFractional non-ablative lasers keep the epidermis intact, while fractional ablative lasers remove it, making them theoretically more effective.OBJECTIVESTo evaluate the clinical and histological alterations induced by fractional photothermolysis for treating photoaging, comparing the possible equivalence of multiple sessions of 1540nm Erbium, to one session of 2940nm Erbium.METHODSEighteen patients (mean age 55.9) completed the treatment with three sessions of 1540nm fractional Erbium laser on one side of the face (50 mJ/mB, 15ms, 2 passes), and one session of 2940nm on the other side (5mJ/mB, 0.25ms, 2 passes). Biopsies were performed before and 3 months after treatment. Clinical, histological and morphometric evaluations were carried out.RESULTSAll patients presented clinical improvement with no statistically significant difference (p> 0.05) between the treated sides. Histopathology revealed a new organization of collagen and elastic fibers, accompanied by edema, which was more evident with the 2940nm laser. This finding was confirmed by morphometry, which showed a decrease in collagen density for both treatments, with a statistical significance for the 2940nm laser (p > 0.001).CONCLUSIONSThree 1540nm sessions were clinically equivalent to one 2940nm session. The edema probably contributed to the positive results after three months, togheter with the new collagen and elastic fibers organization. The greater edema after the 2940nm session indicates that dermal remodeling takes longer than with 1540nm. It is possible that this histological superiority relates to a more prolonged effect, but a cohort longer than three months is needed to confirm that supposition.

show abstract

High-Resolution Ultrasound Imaging to Demonstrate and Predict Efficacy of Carbon Dioxide Fractional Resurfacing Laser Treatment

Cited by 35 publications

References 25 publications

High-frequency (20-50 MHz) ultrasonography of pseudoxanthoma elasticum skin lesions

High-frequency (20-50 MHz) ultrasonography of pseudoxanthoma elasticum skin lesions

Efficacy and safety of a single treatment using a 10,600-nm carbon dioxide fractional laser for mild-to-moderate atrophic acne scars in Asian skin

Fractional Erbium laser in the treatment of photoaging: randomized comparative, clinical and histopathological study of ablative (2940nm) vs. non-ablative (1540nm) methods after 3 months

Contact Info

Product

Resources

About