High-resolution ultrasound for keloids and hypertrophic scar assessment

El-Refaie, Asmaa M; Salem, Rehab Mohammed; Faheem, Mohamed H.

doi:10.1007/s10103-019-02830-4

Cited by 27 publications

(23 citation statements)

References 19 publications

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“…Elrefaie et al compared the Vancouver Scar Scale (VSS) and clinical assessment scoring system, to analyze the value of high-resolution ultrasound for scar assessment. It was found that after three courses of laser treatment, the Vancouver Scar Scale score significantly decreased, ultrasound showed a notable improvement in lesion thickness and echogenicity, and there was evident difference between the percentage of improvement measured by VSS and high-resolution ultrasound (P � 0.001) [13]. e results of this study showed that the skin thickness of groups A and B was considerably higher relative to that of group C (P < 0.05).…”

Section: Discussionmentioning

confidence: 51%

Wavelet Bilateral Filter Algorithm-Based High-Frequency Ultrasound Image Analysis on Effects of Skin Scar Repair

Xuan

Liu

et al. 2021

Scientific Programming

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It aimed to explore the application value of high-frequency ultrasound image based on the wavelet bilateral filtering algorithm in the repair evaluation of hypertrophic scar and keloid, as well as the expression change of nerve growth factor (NGF). 72 patients with scars admitted to hospital from October 2018 to October 2019 were chosen and classified as hypertrophic scar patients (group A) and keloid patients (group B), with 36 cases in each group. All patients received scar repair treatment, and another 30 normal skin volunteers (group C) were selected. High-frequency ultrasound images based on the wavelet bilateral filter algorithm were utilized for skin examination. The expression differences of NGF and pro-NGF in each group were measured by immunohistochemical staining and Western blot. The results showed that the denoising effect (signal-to-noise ratio (PSNR) = 33.2762), structural similarity (SSIM = 0.8963), and edge similarity (FoM = 0.2975) of the proposed algorithm were better than those of bilateral filtering and wavelet soft-threshold algorithms. The skin thickness of groups A and B was considerably higher relative to that of group C ( P < 0.05), but the echo intensity of the skin dermis of groups A and B was evidently inferior to that of group C ( P < 0.05). The results of immunohistochemistry showed that in contrast to group C, the average optical density of NGF in groups A and B increased remarkably ( P < 0.01). In contrast to group C, the positive expression of pro-NGF in groups A and B was notably reduced ( P < 0.05). Western blot results showed that relative to group C, the expression of NGF protein in groups A and B was increased greatly ( P < 0.01), but the expression of pro-NGF protein in groups A and B was reduced ( P < 0.01). The results suggested that the wavelet bilateral filter algorithm can be adopted to evaluate pathological skin scars, and pathological skin scar formation was closely related to the expression levels of NGF and pro-NGF.

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Section: Discussionmentioning

confidence: 51%

Wavelet Bilateral Filter Algorithm-Based High-Frequency Ultrasound Image Analysis on Effects of Skin Scar Repair

Xuan

Liu

et al. 2021

Scientific Programming

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“…Color Doppler is tried in assessment of keloid to evaluate the keloid vascularity, thickness, volume, presence of blood flow showing type of vascularity, thickness of vessels, peak systolic velocity of the vessels. Also it detects any changes not evaluated by the scales as calcifications or fistula to determine which treatment is suitable for each case, moreover it is used to assess the response of keloid scars to different modalities [14,16,17] . [15] Scale †None of the scar scales measure the following: 1).…”

Section: Pre-treatment Evaluation Scores For Keloid Assessmentmentioning

confidence: 99%

Updates on keloid scar pathogenesis, assessment and treatment modalities

Elazhary¹,

Al-Salam

Hafiz

et al. 2022

Journal of Recent Advances in Medicine

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“…(Assiotis et al, 2012;Nelson et al, 2013;Kwan et al, 2015;Vadalà et al, 2016;Daish et al, 2018;Lisi et al, 2019). There are a wide range of methods for assessment of healing like bioelectrical impedance measurement, ultrasound, laser imaging, MRI (Khan et al, 2016;Jan et al, 2018;Elrefaie et al, 2020;Bretschneider et al, 2020). So far, researchers have discovered a wide range of outcomes following the use of PEMF stimulators to promote repair.…”

Section: Introductionmentioning

confidence: 99%

Wound Healing in Humans by Optimization of Low Frequency Signal for Pulsed Electromagnetic Field Therapy

Khan

Sirdeshmukh

2021

JEBAS

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A wound, in clinical terms, is any tissue injury that causes skin rupture which penetrates epidermis and dermis layers leading to uncovering of underneath tissues or organs. Wounds can be superficial or deep, acute or chronic, with minor to serious implications depending on the source, extent, and location. Pulsed Electromagnetic Fields (PEMF) may have varying effects depending on the type of target tissue. Triggering a biological event requires a specific signal to be applied. The effectiveness of a PEMF device is mostly determined by the waveforms utilized in conjunction with the pulsing frequency. Choosing the right PEMF signal is a crucial step in developing a device that can address the challenges associated with chronic wound healing and speed up the healing process. Therefore, the optimization of the signal generator unit in the PEMF system for wound healing applications is a necessity before starting the further process. Hence, the present work of optimization of the PEMF system was carried out by selecting an optimal signal on the signal generator which produces a significant quantity of current in the particular tissue site to provide improved wound healing results. A total of 120 signal generator designs were simulated and optimized to six signal generators having frequencies of 10Hz, 20Hz, 30Hz, 40Hz, 50Hz, and 100Hz and duty cycle 25%. For both groups, the average frequency and duty cycle were calculated and tested using independent samples t-test to see if there were any differences between them. No statistically significant difference was found for frequency (p=0.9977) and duty cycle (p=0.5090). Because of the necessity of the right PEMF signal selection for every trial to be successful, this work will act as a gateway for selecting, understanding,` and considering the proper signal which could initiate the respective biological effect and accelerate the wound healing process.

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High-resolution ultrasound for keloids and hypertrophic scar assessment

Cited by 27 publications

References 19 publications

Wavelet Bilateral Filter Algorithm-Based High-Frequency Ultrasound Image Analysis on Effects of Skin Scar Repair

Wavelet Bilateral Filter Algorithm-Based High-Frequency Ultrasound Image Analysis on Effects of Skin Scar Repair

Updates on keloid scar pathogenesis, assessment and treatment modalities

Wound Healing in Humans by Optimization of Low Frequency Signal for Pulsed Electromagnetic Field Therapy

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