High-Resolution Spectral Analysis Accurately Identifies the Bacterial Signature in Infected Chronic Foot Ulcers in People With Diabetes

Arjunan, Sridhar P.; Tint, Aye Nyein; Aliahmad, Behzad; Kumar, Deepak; Shukla, Ravi; Miller, Julie Ann; Zajac, Jeffrey D; Wang, Gayathiri; Viswanathan, R.; Ekinci, Elif I

doi:10.1177/1534734618785844

Cited by 7 publications

(12 citation statements)

References 20 publications

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“…In most cases (n = 19) the multi‐patient studies were reported 1,2,5,7,54‐68 . However, in some cases (n = 12), the case studies were reported 8,50,69‐78 …”

Section: Resultsmentioning

confidence: 99%

“…In several studies, spectroscopic systems were used at a single 64,65 location to detect spatial heterogeneity of the blood flow. A spectroscopic system was used by Poosapadi et al 68 to discriminate between Staphylococcus aureus and Escherichia coli .…”

Section: Resultsmentioning

confidence: 99%

“…In one study, 68 the spectral signatures of S aureus and E coli were used to discriminate between them. They achieved the 100% sensitivity and 75% specificity in detecting the presence of these infections with 100% negative predicted value in excluding the infection in such wounds.…”

Section: Resultsmentioning

confidence: 99%

“…Spectroscopic data were used in References 64, 65, 68. Not sufficient details to make a determination were provided in Reference 73.…”

Section: Resultsmentioning

confidence: 99%

“…Poosapadari et al 68 used spectroscopy to discriminate between the two most prevalent potential pathogenic microbes in DFU patients ( S aureus and E coli ). They achieved the 100% sensitivity and 75% specificity in detecting the presence of these infections with 100% negative predicted value in excluding the infection in such wounds.…”

Section: Resultsmentioning

confidence: 99%

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Hyperspectral imaging in wound care: A systematic review

Saiko¹,

Lombardi²,

Au³

et al. 2020

International Wound Journal

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Multispectral and hyperspectral imaging (HSI) are emerging imaging techniques with the potential to transform the way patients with wounds are cared for, but it is not clear whether current systems are capable of delivering real‐time tissue characterisation and treatment guidance. We conducted a systematic review of HSI systems that have been assessed in patients, published over the past 32 years. We analysed 140 studies, including 10 different HSI systems. Current in vivo HSI systems generate a tissue oxygenation map. Tissue oxygenation measurements may help to predict those patients at risk of wound formation or delayed healing. No safety concerns were reported in any studies. A small number of studies have demonstrated the capabilities of in vivo label‐free HSI, but further work is needed to fully integrate it into the current clinical workflow for different wound aetiologies. As an emerging imaging modality for medical applications, HSI offers great potential for non‐invasive disease diagnosis and guidance when treating patients with both acute and chronic wounds.

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“…In most cases (n = 19) the multi‐patient studies were reported 1,2,5,7,54‐68 . However, in some cases (n = 12), the case studies were reported 8,50,69‐78 …”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

“…Spectroscopic data were used in References 64, 65, 68. Not sufficient details to make a determination were provided in Reference 73.…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Hyperspectral imaging in wound care: A systematic review

Saiko¹,

Lombardi²,

Au³

et al. 2020

International Wound Journal

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Diagnosis of infection in the foot in diabetes: a systematic review

Senneville

Lipsky

Abbas

et al. 2020

Diabetes Metabolism Res

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Background Securing an early accurate diagnosis of diabetic foot infections and assessment of their severity are of paramount importance since these infections can cause great morbidity and potentially mortality and present formidable challenges in surgical and antimicrobial treatment. Methods In June 2018, we searched the literature using PuEbMed and EMBASE for published studies on the diagnosis of diabetic foot infection. On the basis of predetermined criteria, we reviewed prospective controlled, as well as noncontrolled, studies in any language, seeking translations for those not in English. We then developed evidence statements on the basis of the included papers. Results From the 4242 records screened, we selected 35 papers that met our inclusion criteria. The quality of all but one of the evidence statements was low because of the weak methodology of nearly all of the studies. The available data suggest that diagnosing diabetic foot infections on the basis of clinical signs and symptoms and classified according to the International Working Group of the Diabetic Foot scheme correlates with the patient's likelihood of ulcer healing, of lower extremity amputation, and risk of death. Elevated levels of selected serum inflammatory markers are supportive, but not diagnostic, of soft tissue or bone infection. In patients with suspected diabetic foot osteomyelitis, both a positive probe‐to‐bone test and an elevated erythrocyte sedimentation rate are strongly associated with its presence. Culturing tissue samples of soft tissues or bone, when care is taken to avoid contamination, provides more accurate microbiological information than culturing superficial (swab) samples. Plain X‐ray remains the first‐line imaging examination when there is suspicion of diabetic foot osteomyelitis, but advanced imaging methods help in cases when either the diagnosis or the localization of infection is uncertain. Conclusion The results of this first reported systematic review on the diagnosis of diabetic foot infections provide some guidance for clinicians, but there is a need for more prospective controlled studies of high quality.

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Biofilms and Impaired Wound Healing: How Do We Detect the Presence of Biofilms in Chronic Wounds Non-invasively

Thaarup

Bjarnsholt

2023

Chronic Wound Management

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High-Resolution Spectral Analysis Accurately Identifies the Bacterial Signature in Infected Chronic Foot Ulcers in People With Diabetes

Cited by 7 publications

References 20 publications

Hyperspectral imaging in wound care: A systematic review

Hyperspectral imaging in wound care: A systematic review

Diagnosis of infection in the foot in diabetes: a systematic review

Biofilms and Impaired Wound Healing: How Do We Detect the Presence of Biofilms in Chronic Wounds Non-invasively

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