High-resolution solid state 13C nuclear magnetic resonance spectra of 3,4-methylenedioxyamphetamine hydrochloride and related compounds and their mixtures with lactose

Lee, Garry S. H.; Taylor, Renee C.; Dawson, Michael J.; Kannangara, G. S. Kamali; Wilson, Michael

doi:10.1016/s0926-2040(00)00071-0

Cited by 13 publications

(4 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These are α,α′-dimethyldiphenethylamine and N ,α,α′-trimethyldiphenethylamine. These two impurities were originally associated with the Leuckart method in the 1970’s (by Barron et al, 18 and Kram and Kreugal 1 ), but it was not possible at that time to preclude them from being formed by other synthetic methods. In the present study, these two impurities were only identified in the samples synthesized by the Leuckart method.…”

Section: Resultsmentioning

confidence: 99%

Characterization of Route Specific Impurities Found in Methamphetamine Synthesized by the Leuckart and Reductive Amination Methods

et al. 2009

View full text Add to dashboard Cite

Impurity profiling of seized methamphetamine can provide very useful information in criminal investigations and, specifically, on drug trafficking routes, sources of supply, and relationships between seizures. Particularly important is the identification of “route specific” impurities or those which indicate the synthetic method used for manufacture in illicit laboratories. Previous researchers have suggested impurities which are characteristic of the Leuckart and reductive amination (Al/Hg) methods of preparation. However, to date and importantly, these two synthetic methods have not been compared in a single study utilizing methamphetamine hydrochloride synthesized in-house and, therefore, of known synthetic origin. Using the same starting material, 1-phenyl-2-propanone (P2P), 40 batches of methamphetamine hydrochloride were synthesized by the Leuckart and reductive amination methods (20 batches per method). Both basic and acidic impurities were extracted separately and analyzed by GC/MS. From this controlled study, two route specific impurities for the Leuckart method and one route specific impurity for the reductive amination method are reported. The intra- and inter-batch variation of these route specific impurities was assessed. Also, the variation of the “target impurities” recently recommended for methamphetamine profiling is discussed in relation to their variation within and between production batches synthesized using the Leuckart and reductive amination routes.

show abstract

Section: Resultsmentioning

confidence: 99%

Characterization of Route Specific Impurities Found in Methamphetamine Synthesized by the Leuckart and Reductive Amination Methods

et al. 2009

View full text Add to dashboard Cite

show abstract

“…The solid‐state 13 C NMR analysis of several amphetamines and their mixtures with lactose monohydrate have been reported 144. The lactose monohydrate mixture of one amphetamine (3,4‐methylenedioxyamphetamine hydrochloride) produced distinct chemical shift differences for the amphetamine resonances, and the authors attribute the changes to relaxed crystal packing forces rather than hydrogen bonding.…”

Section: Pharmaceutical Applicationsmentioning

confidence: 99%

Solid-State Nuclear Magnetic Resonance Spectroscopy-Pharmaceutical Applications

Tishmack

Bugay

Byrn

2003

Journal of Pharmaceutical Sciences

195

160

View full text Add to dashboard Cite

“…One of the most important advantages is that NMR can quickly and accurately provide a wealth of structural information about compounds without destroying the properties of the compound [ 14 , 15 ]. Recently, both liquid and solid NMR instruments have been used to study illicit drugs [ 16 – 19 ].…”

Section: Introductionmentioning

confidence: 99%

The Application of a Desktop NMR Spectrometer in Drug Analysis

Zhong

Huang

Luo

et al. 2018

International Journal of Analytical Chemistry

View full text Add to dashboard Cite

A desktop NMR spectrometer was used to qualitatively analyze samples in drug-related cases in order to enhance the accuracy of the results and identify new drugs. Twelve known drugs and their derivatives were used to establish the parameters, conditions, and procedures for the methods and validate the feasibility and reliability of the methods. First, 1-D and 2-D NMR data for these 12 drugs and their derivatives were obtained in detail using a 600-MHz NMR spectrometer to create a data library. Next, some of these 12 drugs were analyzed using a Picospin 80 MHz desktop NMR spectrometer to set up the analytical procedure and method. With the procedure and method established, real case samples were analyzed and the data were compared to those obtained by a standard method. The results indicate that the desktop NMR spectrometer is a reliable and promising approach that can be used in criminology to quickly identify whether or not samples contain illegal drugs.

show abstract

High-resolution solid state 13C nuclear magnetic resonance spectra of 3,4-methylenedioxyamphetamine hydrochloride and related compounds and their mixtures with lactose

Cited by 13 publications

References 23 publications

Characterization of Route Specific Impurities Found in Methamphetamine Synthesized by the Leuckart and Reductive Amination Methods

Characterization of Route Specific Impurities Found in Methamphetamine Synthesized by the Leuckart and Reductive Amination Methods

Solid-State Nuclear Magnetic Resonance Spectroscopy-Pharmaceutical Applications

The Application of a Desktop NMR Spectrometer in Drug Analysis

Contact Info

Product

Resources

About