High-Resolution Small Animal Imaging

Schäfers, Klaus P.; Bolwin, Konstantin; Büther, Florian; Hermann, Sven; Kösters, Thomas; Kuhlmann, Michael; Schäfers, Michael; Viel, Thomas

doi:10.1016/b978-0-444-53632-7.00110-6

Cited by 4 publications

(3 citation statements)

References 122 publications

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“…The photoelectric effect strongly depends on Z, having dominance preferably in elements with high Z and with low energy photons. The greatest contribution of photoelectric absorption to the mass attenuation coefficient occurs at 88 keV [20].…”

Section: Photoelectric Effectmentioning

confidence: 99%

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A Brief Review on the High-Energy Electromagnetic Radiation-Shielding Materials Based on Polymer Nanocomposites

Acevedo-Del-Castillo

Águila-Toledo

Maldonado-Magnere

et al. 2021

IJMS

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This paper revises the use of polymer nanocomposites to attenuate high-energy electromagnetic radiation (HE-EMR), such as gamma radiation. As known, high-energy radiation produces drastic damage not only in facilities or electronic devices but also to life and the environment. Among the different approaches to attenuate the HE-EMR, we consider the use of compounds with a high atomic number (Z), such as lead, but as known, lead is toxic. Therefore, different works have considered low-toxicity post-transitional metal-based compounds, such as bismuth. Additionally, nanosized particles have shown higher performance to attenuate HE-EMR than those that are micro-sized. On the other hand, materials with π-conjugated systems can also play a role in spreading the energy of electrons ejected as a consequence of the interaction of HE-EMR with matter, preventing the ionization and bond scission of polymers. The different effects produced by the interactions of the matter with HE-EMR are revised. The increase of the shielding properties of lightweight, flexible, and versatile materials such as polymer-based materials can be a contribution for developing technologies to obtain more efficient materials for preventing the damage produced for the HE-EMR in different industries where it is found.

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Section: Photoelectric Effectmentioning

confidence: 99%

“…This photon is transformed after passing through a Coulombic field, normally belonging to an atomic nucleus. This type of interaction of radiation with matter is the main one at high energies, above 1022 MeV [20,23]. This value is best described as Equation (1).…”

Section: Pair Productionmentioning

confidence: 99%

A Brief Review on the High-Energy Electromagnetic Radiation-Shielding Materials Based on Polymer Nanocomposites

Acevedo-Del-Castillo

Águila-Toledo

Maldonado-Magnere

et al. 2021

IJMS

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“…In vivo tracing of molecular processes in time and space is one of the key capabilities of Positron Emission Tomography (PET). The application of PET in small animals, such as mice or rats, is a widely used method in biomedical research [1]. Due to the small regions of interest, the spatial resolution of small animal PET systems play a major role in studying molecular processes in vivo [2].…”

mentioning

confidence: 99%

Development of a clear sub-millimeter small animal PET scanner by reducing the influence of the non-collinearity effect

et al. 2017

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Small animal PET plays a major role in studying molecular processes in vivo. However, the spatial resolution of small animal PET is limited by physical effects like positron range, photon non-collinearity, and object scattering. The aim of this project was to minimize the influence of the non-collinearity effect by reducing the distance between the coincidence detectors leading to an improved spatial resolution. A multi-wire proportional chamber-based high-resolution PET scanner (quadHIDAC) was used, offering a spatial resolution of nearly 1 mm FWHM. By removing two opposite detector banks of the 4-detector-setup, the inner distance between the two remaining detector plates could be reduced from 180 mm to 40 mm. List mode acquisitions of a small point source (22Na) experiment were performed, images were reconstructed (0.25 mm voxel size) using a one-pass list-mode EM algorithm and the FWHM in the radial, tangential, and axial directions was calculated. In addition, a Jaszczak phantom (hole sizes of 0.7 up to 1.2 mm) was acquired with both scanners. The prototype high-resolution PET scanner showed improved spatial resolution in radial (0.9 mm FWHM), tangential (0.9 mm FWHM), and axial (0.8 mm FWHM) direction compared to the quadHIDAC scanner (1.x mm, 1.x mm, 1.x mm), respectively offering clear sub-millimeter imaging. Blurring effects due to photon non-collinearity could be reduced by minimizing the detector distance.

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Multi-layered structures for lightweight providing shielding from unintended radiation exposure for pediatric patients

Kwon

Han

Kim

et al. 2023

Radiation Physics and Chemistry

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High-Resolution Small Animal Imaging

Cited by 4 publications

References 122 publications

A Brief Review on the High-Energy Electromagnetic Radiation-Shielding Materials Based on Polymer Nanocomposites

A Brief Review on the High-Energy Electromagnetic Radiation-Shielding Materials Based on Polymer Nanocomposites

Development of a clear sub-millimeter small animal PET scanner by reducing the influence of the non-collinearity effect

Multi-layered structures for lightweight providing shielding from unintended radiation exposure for pediatric patients

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