High resolution osteoclast-targeted imaging-guided osteoporosis alleviation via persistent luminescence nanocomposite

Lin, Xiao; Zhang, Kewen; Li, Yang; Nan, Fang; Li, Jun; Zhang, Hui; Deng, Wei; Ding, Weihang; Li, Kaixuan; Jarhen, Nur; Zhou, Yitong; Yu, Xiao; Hao, Wan; Shi, Di; Dong, Xiangyu; Wu, Shu-Qi; Yin, Xue-Bo

doi:10.1016/j.cej.2024.149468

Cited by 1 publication

(1 citation statement)

References 51 publications

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“…Persistent luminescence nanoparticles (PLNPs) can store energy from the excitation source and then release it for afterglow emission. − Their non-in situ excitation could eliminate the interference from autofluorescence and scattered light. − If near-infrared (NIR) afterglow is realized for PLNPs, the imaging efficiency could be improved for the deep tissue penetration of NIR afterglow and the high resolution of optical imaging. − Thus, NIR afterglow for PLNPs with non-in situ excitation is perfect for imaging application. PLNPs are composited with the host, emission center, and trap, while emission centers govern the emission wavelength .…”

Section: Introductionmentioning

confidence: 99%

Cr-Free Bismuth-Based Persistent Luminescence Nanoparticle Composite for Cancer Theranostics

Aiwaili,

Zhao,

Abdurahman

et al. 2024

ACS Appl. Nano Mater.

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Near-infrared (NIR) persistent luminescence nanoparticles (PLNPs) showed great potential for bioimaging due to their integration of non-in situ excitation and deep tissue penetration. However, PLNPs are often introduced with Cr 3+ ions as the NIR emission centers. Herein, we report Cr-free Bi 2 Ga 3.985 O 9 :1.5% Fe 3+ (BGF), with Fe 3+ ions as the NIR emission centers. BGF under 310 nm excitation exhibited NIR afterglow emission at 794 nm in the first biological imaging window (650− 950 nm), with the afterglow duration of 3 h. BGF was grafted with hydroxyl groups and then polydopamine (PDA) for the integration of indocyanine green (ICG) through π−π stacking and hydrophobic interactions, as the PLNP−PDA−ICG composite. Bi in the composite, as a heavy atom element, exhibits computed tomography (CT) contrast capacity, while PDA is a photothermal agent, and ICG is excited to produce reactive oxide species for photodynamic therapy. The afterglow/CT dual-modality imaging-guided photothermal/photodynamic combination therapy was validated with in vitro/vivo imaging and therapeutic applications. This work provides the Cr-free PLNP composite for drug-free theranostics with a low toxicity.

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