High resolution MRI relaxation measurements of water in the articular cartilage of the meniscectomized rat knee at 4.7 T

Spandonis, Yiannis; Heese, Frank P.; Hall, Laurance D.

doi:10.1016/j.mri.2004.02.010

Cited by 38 publications

(25 citation statements)

References 30 publications

(41 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In contrast, the T 2 increase in OA when averaged over the total cartilage plate was only 17% (48), 28% (17), and 40 -70% (18), and total femoral cartilage T 2 in children with juvenile rheumatoid arthritis (RA) was increased by 5 ms as compared to healthy controls (49). Thus, on the one hand, the calculated precision errors in our study seem reasonably small in comparison to the differences that can be expected between healthy and diseased cartilage, suggesting a good discriminatory power of this technique.…”

Section: Discussionmentioning

confidence: 94%

“…T 2 relaxation times (T 2 ) have been shown to correlate with the water content (5) and structural properties of the collagenous fiber architecture (6 -8) in articular cartilage. T 2 has been demonstrated to be sensitive to experimental alterations of the cartilage matrix entailing impaired biomechanical properties (9 -14), and degenerative changes of cartilage in joints with osteoarthritis (OA) (15)(16)(17)(18)(19), and can depict focal areas of abnormality in cartilage (20,21). According to recent studies (4,14), T 2 is likely to provide more complementary data on cartilage morphology than the delayed gadolinium enhanced MRI contrast (dGEM-RIC) (22) and volumetric techniques (1), and may help identify cartilage at risk of developing irreversible degeneration (4).…”

mentioning

confidence: 99%

See 1 more Smart Citation

Global and regional reproducibility of T₂ relaxation time measurements in human patellar cartilage

Gläser¹,

Mendlik²,

Dinges³

et al. 2006

Magnetic Resonance in Med

View full text Add to dashboard Cite

Seven T 2 maps (multiecho (ME) sequence: 3000 ms, eight echoes with 13.2 ms of echo spacing, 20 sections) and T 1 -weighted (T 1 -w) fast low-angle shot (FLASH-water excitation (WE)) data sets from four imaging sessions (right patellae of 10 healthy volunteers) were obtained. A segmentation of cartilage (WE sequence) was overlaid on the ME data and T 2 values were calculated for total cartilage, three layers, three facets (global), and 240 ROIs (regional). Reproducibility (precision error) was calculated as the root mean square average (RMSA) of the individual coefficients of variation (COVs, %) and standard deviations (SDs, ms) for intra-and intersession reproducibility. The precision error was 3-7% and 6 -29% for global and regional T 2 , respectively. There was no difference between intraand intersession reproducibility, but there was worse reproducibility in the superficial layers compared to the deeper layers. Peripheral ROI reproducibility (mean ‫؍‬ 13%) was worse than in the central portions (mean ‫؍‬ 11%), but omission of the periphery did not positively affect the globally calculated T 2 reproducibility. The precision errors were small compared to reported changes in diseased cartilage, suggesting good discriminatory power of the technique. Our data provide a first estimate of global and regional reproducibility errors of T 2 in healthy cartilage, and may serve as a basis for sample size calculations and aid study designs for longitudinal and cross-sectional trials in osteoarthritis (OA). Magn Reson Med 56:527-534, 2006.

show abstract

Section: Discussionmentioning

confidence: 94%

mentioning

confidence: 99%

Global and regional reproducibility of T₂ relaxation time measurements in human patellar cartilage

Gläser¹,

Mendlik²,

Dinges³

et al. 2006

Magnetic Resonance in Med

View full text Add to dashboard Cite

show abstract

“…Degeneration changes have been shown to lead to increases in T2 in human articular cartilage (Dardzinski et al 1997). Spandonis et al (2004) measured the weight-bearing cartilage areas on the meniscectomized condyles in rats and they found a significant increase of cartilage T2 relaxation time. Mosher et al (2000) examined the spatial variation of in vivo T2 in symptomatic and asymptomatic human articular cartilage and concluded that T2 relaxation times are substantially elevated in OA subjects compared with healthy subjects.…”

Section: Interpretation Of Knee Joint Mr Imagesmentioning

confidence: 99%

In vivo magnetic resonance imaging of animal models of knee osteoarthritis

Wáng

2008

Lab Anim

View full text Add to dashboard Cite

SummaryRecent technical developments in high-field magnetic resonance (MR) scanners, improvement in radio frequency coil design and gradient performance along with the development of efficient pulse sequences and new methods of enhancing contrast have made high-quality imaging of animal arthritis models feasible. MR can provide high-resolution structural information about the osteoarthritic changes in animal models, and also information about the biophysical properties of cartilage. This paper reviews the MR techniques available for animal knee imaging, and the various MR-derived readouts of knee osteoarthritis in animal models. Pitfalls in interpreting animal joint anatomy and joint composition are highlighted.

show abstract

“…Starting from its top surface (articular surface), cartilage is commonly subdivided into at least three structural zones, namely the superficial zone (SZ) in which the collagen fibers are aligned in parallel to the tissue surface, the transitional zone (TZ) where the fibers are in random orientation, and the radial zone (RZ) where fibers are perpendicular to the surface (1)(2)(3). Cartilage degradation causes the tissue to lose its loadbearing ability, which develops into the most common degenerative joint disease, osteoarthritis (OA) (4,5). Early detection of cartilage degeneration is the definitive yet…”

Section: Introductionmentioning

confidence: 99%

Image interpolation improves the zonal analysis of cartilage T2 relaxation in MRI

Badar

Xia

2017

Quant. Imaging Med. Surg.

View full text Add to dashboard Cite

Background: This project aimed to investigate the improvement in the detection of osteoarthritis (OA) in cartilage by the interpolation of T2 images, in the situation when the native MRI resolution is insufficient to resolve the depth-dependent T2 characteristics in articular cartilage (AC).Methods: Eighteen intact canine knee joints that were healthy or had mild (contralateral) or severe OA were T2-imaged in a 7T/20 cm MRI system at 200 µm/pixel resolution (macro-MRI). Two image analysis methods were used to interpolate the images to 100 µm/pixel, i.e., by Fourier-transforming the time-domain FID (Free Induction Decay) signal using the Varian NMR software and by interpolating the 2D T2 image using the ImageJ software. and the interpolated 100 µm resolutions were subdivided into two equal-thickness regions and three-equal thickness regions based on clinical MRI protocols. A new method divided the T2 profiles into three-unequal thickness zones according to the T2 profiles at 17.6 µm/pixel from the same cartilage imaged in a 7 Tesla/9 cm µMRI system. Both interpolation methods improved the depth-dependent T2 images/profiles in macro-MRI. The unequal zone division in T2 had better OA sensitivity than the equal zone division. The threeequal zone division of T2 profiles had better OA sensitivity than the two-equal zone division. The statistical significant difference between the healthy and mild OA cartilage is detected (P=0.0018) only by the unequal zone division method at 100 µm resolution.Conclusions: Data interpolation improves the T2 sensitivity in MRI of cartilage OA. Unequal division of tissue thickness enables better early stage of OA detection than the equal division.

show abstract

High resolution MRI relaxation measurements of water in the articular cartilage of the meniscectomized rat knee at 4.7 T

Cited by 38 publications

References 30 publications

Global and regional reproducibility of T₂ relaxation time measurements in human patellar cartilage

Global and regional reproducibility of T₂ relaxation time measurements in human patellar cartilage

In vivo magnetic resonance imaging of animal models of knee osteoarthritis

Image interpolation improves the zonal analysis of cartilage T2 relaxation in MRI

Contact Info

Product

Resources

About

High resolution MRI relaxation measurements of water in the articular cartilage of the meniscectomized rat knee at 4.7 T

Cited by 38 publications

References 30 publications

Global and regional reproducibility of T2 relaxation time measurements in human patellar cartilage

Global and regional reproducibility of T2 relaxation time measurements in human patellar cartilage

In vivo magnetic resonance imaging of animal models of knee osteoarthritis

Image interpolation improves the zonal analysis of cartilage T2 relaxation in MRI

Contact Info

Product

Resources

About

Global and regional reproducibility of T₂ relaxation time measurements in human patellar cartilage

Global and regional reproducibility of T₂ relaxation time measurements in human patellar cartilage