High‐resolution mitochondrial DNA analysis sheds light on human diversity, cultural interactions, and population mobility in Northwestern Amazonia

Arias, Liliana; Barbieri, Chiara; Barreto, Guillermo; Stoneking, Mark; Pakendorf, Brigitte

doi:10.1002/ajpa.23345

Cited by 47 publications

(66 citation statements)

References 80 publications

(86 reference statements)

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“…4), which is not consistent with the traditional portrait of isolation between Amazonian populations. This genetic diversity complements the evidence from other disciplines that the region was also home to dynamic, non-isolated population groups 12 . In particular, the linguistic diversity of Amazonia includes not just language isolates but major, expansive language families, with farreaching geographic distributions 36 , reflecting long-range migrations of at least some speakers, and possibly major demographic expansions.…”

Section: Discussionsupporting

confidence: 80%

“…Y chromosome haplogroup assignment was performed with the yHaplo software 76 . Data was cross-checked with available published mtDNA and Y chromosome data for the same individuals, assigned via direct genotyping/sequencing in previous studies 12,31,53 : the SNPs available allowed the correct macro haplogroup to be detected in 97% of cases.…”

Section: Uniparental Markersmentioning

confidence: 99%

“…It is difficult to trace how these ancestral genetic components have survived in living populations, as there is a lack of dense sampling of populations with a high proportion of Native American ancestry. This also impacts our understanding of pre-colonial local scale dynamics, with only a few studies reporting a good sampling coverage for targeted regions 11,12 .…”

Section: Introductionmentioning

confidence: 99%

“…This model builds on evidence for major complex societies in the Andes (culminating with the well-known but short-lived Inca empire) which fostered population movements and connections, counterbalanced by the traditional view of the Amazon basin as the homeland of small, isolated tribes. The latter view is challenged by increasing evidence of large-scale societies 16,17 , the role of rivers as primary routes for gene-flow 12 , and the presence of important centers of plant domestication 18 . To gain a better representation of the highly diverse cultural landscape of Amazonia, a more intense archaeological effort is needed, together with a more fine-grained sampling of living and ancient human populations.…”

Section: Introductionmentioning

confidence: 99%

“…These studies, based on uniparental markers, revealed intense contact routes in the southern highlands, but not in the northern regions nor in neighboring Amazonia. Relatively few genetic studies have addressed the diffusion of the main language families of Amazonia (notably Arawak, Tupí or Carib), although very recent research does focus on sub-branches or smaller families 12,34 . Some scholars suggest a major role for cultural contact alone behind the diffusion of Arawak 35 .…”

Section: Introductionmentioning

confidence: 99%

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The genomic landscape of western South America: Andes, Amazonia and Pacific Coast

Barbieri

Barquera

Arias

et al. 2018

Preprint

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Studies of Native South American genetic diversity have helped to shed light on the peopling and differentiation of the continent, but available data are sparse for the major ecogeographic domains. These include the Pacific Coast, a potential early migration route; the Andes, home to the most expansive complex societies and to one of the most spoken indigenous language families of the continent (Quechua); and Amazonia, with its understudied population structure and rich cultural diversity. Here we explore the genetic structure of 177 individuals from these three domains, genotyped with the Affymetrix Human Origins array. We infer multiple sources of ancestry within the Native American ancestry component; one with clear predominance on the Coast and in the Andes, and at least two distinct substrates in neighboring Amazonia, with a previously undetected ancestry characteristic of northern Ecuador and Colombia. Amazonian populations are also involved in recent gene-flow with each other and across ecogeographic domains, which does not accord with the traditional view of small, isolated groups. Long distance genetic connections between speakers of the same language family suggest that languages had spread not by cultural contact alone. Finally, Native American populations admixed with post-Columbian European and African sources at different times, with few cases of prolonged isolation. With our results we emphasize the importance of including understudied regions of the continent in high-resolution genetic studies, and we illustrate the potential of SNP chip arrays for informative regional scale analysis.

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Section: Discussionsupporting

confidence: 80%

Section: Uniparental Markersmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The genomic landscape of western South America: Andes, Amazonia and Pacific Coast

Barbieri

Barquera

Arias

et al. 2018

Preprint

Self Cite

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Uniparental genetic markers in Native Americans: A summary of all available data from ancient and contemporary populations

Bisso‐Machado

Fagundes

2021

American J Phys Anthropol

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Objectives The aim of this study was to create a comprehensive summary of available mtDNA and Y‐chromosome data for Native Americans from North, Central, and South America, including both modern and ancient DNA. To illustrate the usefulness of this dataset we present a broad picture of the genetic variation for both markers across the Americas. Methods We searched PubMed, ResearchGate, Google Scholar for studies about mtDNA or Y‐chromosome variation in Native American populations, including geographic, linguistic, ecological (ecoregion), archeological and chronological information. We used AMOVA to estimate the genetic structure associated with language and ecoregion grouping and Mantel tests to evaluate the correlation between genetic and geographic distances. Results Genetic data were obtained from 321 primary sources, including 22,569 individuals from 298 contemporary populations, and 3628 individuals from 202 archeological populations. MtDNA lineages of probable non‐Amerindian origin were rare, in contrast with Y‐chromosome lineages. Mantel tests showed a statistically significant correlation for the whole continent considering mtDNA but not the Y‐chromosome. Genetic structure between groups was always stronger for mtDNA than for the Y‐chromosome. Conclusions This study summarizes decades of research conducted in Native American populations for both mtDNA and the Y‐chromosome. Continental or sub‐continental patterns of variation reveal that most of the genetic variation occurs within populations rather than among linguistic or ecoregional groups, and that isolation by distance is barely detectable in most population sets. The genetic structure among groups was always larger for mtDNA than for the Y‐chromosome, suggesting between‐sex differences in gene flow.

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Bioanthropological analysis of human remains from the archaic and classic period discovered in Puyil cave, Mexico

Navarro‐Romero,

Muñoz,

Krause‐Kyora

et al. 2024

American Journal of Biological Anthropology

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ObjectivesDetermine the geographic place of origin and maternal lineage of prehistoric human skeletal remains discovered in Puyil Cave, Tabasco State, Mexico, located in a region currently populated by Olmec, Zoque and Maya populations.Materials and MethodsAll specimens were radiocarbon (14C) dated (beta analytic), had dental modifications classified, and had an analysis of 13 homologous reference points conducted to evaluate artificial cranial deformation (ACD). Following DNA purification, hypervariable region I (HVR‐1) of the mitogenome was amplified and Sanger sequenced. Finally, Next Generation Sequencing (NGS) was performed for total DNA. Mitochondrial DNA (mtDNA) variants and haplogroups were determined using BioEdit 7.2 and IGV software and confirmed with MITOMASTER and WebHome softwares.ResultsRadiocarbon dating (14C) demonstrated that the inhabitants of Puyil Cave lived during the Archaic and Classic Periods and displayed tabular oblique and tabular mimetic ACD. These pre‐Hispanic remains exhibited five mtDNA lineages: A, A2, C1, C1c and D4. Network analysis revealed a close genetic affinity between pre‐Hispanic Puyil Cave inhabitants and contemporary Maya subpopulations from Mexico and Guatemala, as well as individuals from Bolivia, Brazil, the Dominican Republic, and China.ConclusionsOur results elucidate the dispersal of pre‐Hispanic Olmec and Maya ancestors and suggest that ACD practices are closely related to Olmec and Maya practices. Additionally, we conclude that ACD has likely been practiced in the region since the Middle‐Archaic Period.

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High‐resolution mitochondrial DNA analysis sheds light on human diversity, cultural interactions, and population mobility in Northwestern Amazonia

Cited by 47 publications

References 80 publications

The genomic landscape of western South America: Andes, Amazonia and Pacific Coast

The genomic landscape of western South America: Andes, Amazonia and Pacific Coast

Uniparental genetic markers in Native Americans: A summary of all available data from ancient and contemporary populations

Bioanthropological analysis of human remains from the archaic and classic period discovered in Puyil cave, Mexico

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