2016
DOI: 10.1093/ije/dyw218
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High-resolution metabolomics of occupational exposure to trichloroethylene

Abstract: Background: Occupational exposure to trichloroethylene (TCE) has been linked to adverse health outcomes including non-Hodgkin’s lymphoma and kidney and liver cancer; however, TCE’s mode of action for development of these diseases in humans is not well understood. Methods: Non-targeted metabolomics analysis of plasma obtained from 80 TCE-exposed workers [full shift exposure range of 0.4 to 230 parts-per-million of air (ppma)] and 95 matched controls were completed by ultra-high resolution mass spectrometry. Bio… Show more

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Cited by 94 publications
(69 citation statements)
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References 72 publications
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“…Sample processing and high-resolution mass spectrometry analysis was performed as described previously (Park et al, 2012; Soltow et al, 2013; Go et al, 2015b; Jin et al, 2016; Walker et al, 2016; Cribbs et al, 2016; Li et al, 2017). Acetonitrile (2:1, v/v) was added to 65 μL of plasma containing 14 stable isotope internal standards ([13C6]-D-glucose, [15N]-indole, [2-15N]-L-lysine dihydrochloride, [13C5]-L-glutamic acid, [13C7]-benzoic acid, [3,4-13C2] cholesterol, [15N]-L-tyrosine, [trimethyl-13C3]-caffeine, [15N2]-uracil, [3,3-13C2]-cystine, [1,2-13C2]-palmitic acid, [15N, 13C5]-L-methionine, [15N]-choline chloride, and 2′-deoxyguanosine-15N2,13C10-5′-monophosphate).…”
Section: Methodsmentioning
confidence: 99%
“…Sample processing and high-resolution mass spectrometry analysis was performed as described previously (Park et al, 2012; Soltow et al, 2013; Go et al, 2015b; Jin et al, 2016; Walker et al, 2016; Cribbs et al, 2016; Li et al, 2017). Acetonitrile (2:1, v/v) was added to 65 μL of plasma containing 14 stable isotope internal standards ([13C6]-D-glucose, [15N]-indole, [2-15N]-L-lysine dihydrochloride, [13C5]-L-glutamic acid, [13C7]-benzoic acid, [3,4-13C2] cholesterol, [15N]-L-tyrosine, [trimethyl-13C3]-caffeine, [15N2]-uracil, [3,3-13C2]-cystine, [1,2-13C2]-palmitic acid, [15N, 13C5]-L-methionine, [15N]-choline chloride, and 2′-deoxyguanosine-15N2,13C10-5′-monophosphate).…”
Section: Methodsmentioning
confidence: 99%
“…High-resolution metabolomics (HRM) uses liquid chromatography (LC) coupled to ultra-high resolution mass spectrometry (MS) and advanced data extraction methods to detect thousands of metabolic features quickly (Walker et al, 2016). Samples are analyzed in triplicate to enhance the reliability of detection of low abundance chemicals, and data extraction methods utilize adaptive processing LCMS (apLCMS; Yu et al, 2009) and automated re-extraction, statistical filtering and data merger to enhance data quality (Uppal et al, 2013).…”
Section: A N U S C R I P Tmentioning
confidence: 99%
“… Follow the concept of integrative exposomics Develop bioinformatics approaches that link exposures with biological responses and disease outcomes. The exposome will be represented as multifactorial variables.…”
Section: Exposome Vision and Challengesmentioning
confidence: 99%