High Resolution Mass Spectrometry of Cystine-Containing Neuropeptides in Histological Sections of Human FFPE Tissue Banks
Peter Verhaert,
Gilles Frache,
Dhaka Bhandari
et al.
Abstract:Using our earlier developed protocol, mass spectrometry imaging of small endogenous peptides (and a selection of small metabolites) can be successfully performed directly in tissue sections of formaldehyde-fixed paraffin-embedded (FFPE) samples, such as those available in Homo sapiens biobanks. In analogy with immunohistochemistry (IHC) which employs antibodies as detection probes, this method was designated mass spectrometry histochemistry (MSHC) as it solely relies on (top-down) mass spectrometry for analyte… Show more
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