High-resolution imaging of the central nervous system

Farooq, Hamza; Genis, Helen; Alarcon, Joseph; Vuong, Barry; Jivraj, Jamil; Yang, Victor X. D.; Cohen‐Adad, Julien; Fehlings, Michael G.; Cadotte, David W.

doi:10.1016/bs.pbr.2014.12.011

Cited by 5 publications

(2 citation statements)

References 74 publications

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“…5,21,28,35,53–55,59,64,67,77,117,143,173 Raman is based on the inelastic scattering of photons upon interaction with tissue. Tissue is interrogated with light, and a small amount of this incident light at a specific wavelength is scattered to different wavelengths.…”

Section: Ramanmentioning

confidence: 99%

“…The incident and scattered light are a function of the vibrational energies of molecular bonds in tissues, thus providing a way to differentiate cellular structures based on the chemical specificity of lipids, proteins, and DNA. 28 A major limitation of Raman is its intrinsically weak signals (1 in approximately 10 7 scattered photons is Raman shifted). As such, various techniques have been developed to improve Raman detection sensitivity, including resonance Raman; surface-enhanced Raman scattering (SERS), which can be used to enhance signals from Raman molecules by a factor of 10 7 –10 10 ; and coherent Raman.…”

Section: Ramanmentioning

confidence: 99%

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Optical technologies for intraoperative neurosurgical guidance

Valdés

Roberts

Lü³

et al. 2016

FOC

114

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Biomedical optics is a broadly interdisciplinary field at the interface of optical engineering, biophysics, computer science, medicine, biology, and chemistry, helping us understand light–tissue interactions to create applications with diagnostic and therapeutic value in medicine. Implementation of biomedical optics tools and principles has had a notable scientific and clinical resurgence in recent years in the neurosurgical community. This is in great part due to work in fluorescence-guided surgery of brain tumors leading to reports of significant improvement in maximizing the rates of gross-total resection. Multiple additional optical technologies have been implemented clinically, including diffuse reflectance spectroscopy and imaging, optical coherence tomography, Raman spectroscopy and imaging, and advanced quantitative methods, including quantitative fluorescence and lifetime imaging. Here we present a clinically relevant and technologically informed overview and discussion of some of the major clinical implementations of optical technologies as intraoperative guidance tools in neurosurgery.

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