The aberration in the center position of wavefront can be corrected well when the deformable mirrors (DM) used in highresolution adaptive optics system of telescope. However, for the defocus and spherical aberration of telescope, the four corners of the wavefront cannot be corrected well. A novel correction method with different levels and regions of deformable mirror is proposed to solve this problem. The control elements of wavefront in four corners are divided. And every four or five DM units in one corner is in a group. Compared with conventional correction method, the locationgrouping method showed significant advantages in correction of different order aberrations.