High-resolution human leukocyte antigen (HLA) haplotypes and linkage disequilibrium of HLA-B and -C and HLA-DRB1 and -DQB1 alleles in a Taiwanese population

Refined information on alleles belonging to the C*07:01/07:06/07:18 group in the Korean population

“…Clinically, it seems unlikely that C*07:01 versus C*07:06 mismatched unrelated HSCT procedure has been performed in Korea, because of their conserved and distinct haplotypic associations with the HLA-A, -B, and -DRB1 alleles, which have been primary targets for HLA matching between a patient and a donor. However, C*07:01 versus C*07:06 mismatched transplantation might occur in populations, such as those in Taiwan that exhibit tight associations of both C alleles with the same haplotype, A*33:03-B*44:03-DRB1*07:01-DQB1*02:02 (Table 2) [14].…”

Variants in the promoter region of CYP7A1 are associated with neuromyelitis optica but not with multiple sclerosis in the Han Chinese population

“…However, the genetics of NMO susceptibility remain largely unknown. Recently, the interleukin 17 (IL-17) and HLA-DPB1*0501 allele were reported to be associated with Asian NMO patients positive for the NMO-IgG antibody [12][13][14][15][16][17] , and there was a suggestion that the emergence of anti-AQP4 antibody is reinforced by the presence of the HLA-DPB*0501 and IL-17 allele [13,15] . In addition, CYP7A1 was reported to be associated with Korean NMO patients [18] .…”

Common mutations of familial hypercholesterolemia patients in Taiwan: Characteristics and implications of migrations from southeast China

“…Recently, anthropological studies using genetic markers by human leukocyte antigen and microsatellites revealed that Taiwanese, with Singapore Chinese and ThaiChinese, formed a southern Asian cluster with neighboring groups of Thais and Vietnamese, which is separate from the northern Asian cluster consisting of Koreans and Japanese (Chu et al, 1998;Lin et al, 2001;Yang et al, 2009). Although there have been reports of FH from the southern Chinese (Chang et al, 2003;Charng et al, 2006;Chiou and Charng, 2010;Chiu et al, 2005;Khoo et al, 2000;Mak et al, 1998a;Sun et al, 1994;Tai et al, 1998), the relationships need to be further investigated.…”