High-resolution genetic mapping of the hypodactyly (Hd) locus on mouse Chromosome 6

Innis, Jeffrey W.; Kazen-Gillespie, Kristin A.; Post, Laura; McGorman, Joel P.

doi:10.1007/s003359900002

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Establish Requirement Of a Hox Gene For Normal Accessory Sex1

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1996

2002

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Cited by 7 publications

(1 citation statement)

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“…We then correlated these findings with a specific accessory sex organ phenotype of the Hypodactyly ( Hd ) mutant. Hd is a naturally occurring semidominant mutation with full penetrance that results from a deletion in exon 1 of the Hoxa‐13 gene (Innis et al 1996; Mortlock et al 1996; Post et al 2000). These mice exhibited limb and genital abnormalities (Podlasek et al 1999b; Post and Innis 1999; Robertson et al 1996).…”

Section: Establish Requirement Of a Hox Gene For Normal Accessory Sexmentioning

confidence: 99%

PosteriorHoxgene expression in developing genitalia

Podlasek

Houston

McKenna

et al. 2002

Evolution and Development

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Section: Establish Requirement Of a Hox Gene For Normal Accessory Sexmentioning

confidence: 99%

PosteriorHoxgene expression in developing genitalia

Podlasek

Houston

McKenna

et al. 2002

Evolution and Development

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Cellular analysis of limb development in the mouse mutant Hypodactyly

Robertson¹,

Chapman²,

Adams³

et al. 1996

Dev. Genet.

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The limb defect in the mouse Hypodoctyly (Hd) affects only the distal structures. Heterozygotes (Hd/+) lack all or part of the distal phalanx and the terminal claw of digit 1 on the hindlimbs; mice homozygous (Hd/Hd) for the mutation have just one digit on each of the four limbs. Early limb development in the mutant appears normal and a change in morphology can only be detected later. Limb buds of Hd/+ and Hd/Hd embryos become reduced in width, with Hd/Hd buds becoming very pointed instead of rounded. This change in bud shape is correlated with an increase in cell death anteriorly in Hd/+ hindlimbs and both anteriorly and posteriorly in Hd/Hd fore‐ and hindlimb buds. The apical ectodermal ridge is very pronounced in pointed Hd/Hd limb buds. Mesenchyme cells from the Hd/Hd mutant in culture show a cell‐autonomous change in behaviour and less cartilage differentiates. © 1996 Wiley‐Liss, Inc.

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