High-resolution experimental and computational electrophysiology reveals weak β-lactam binding events in the porin PorB

Abstract

The permeation of most antibiotics through the outer membrane of Gramnegative bacteria occurs through porin channels. To design drugs with increased activity against Gram-negative bacteria in the face of the antibiotic resistance crisis, the strict constraints on the physicochemical properties of the permeants imposed by these channels must be better understood.