High-resolution digital transmission microscopy—a Fourier holography approach

Gustafsson, Mats; Sebesta, Mikael; Bengtsson, Bengt; Pettersson, Sven-Göran; Egelberg, Peter; Lenart, Thomas

doi:10.1016/s0143-8166(02)00214-2

Cited by 45 publications

(28 citation statements)

References 17 publications

(29 reference statements)

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“…Lyophilized HAMLET and oleate-HAMLET were dissolved in phosphate-buffered saline (PBS). Secondary structure predictions were made using K2D3 (34) (35)(36)(37). The interference pattern (hologram) is recorded on a digital sensor and is used to reconstruct the amplitude and phase of the object (38,39).…”

Section: Methodsmentioning

confidence: 99%

Lipids as Tumoricidal Components of Human α-Lactalbumin Made Lethal to Tumor Cells (HAMLET)

Storm

Rydström

et al. 2013

Journal of Biological Chemistry

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Background: HAMLET is a broadly tumoricidal complex of partially unfolded ␣-lactalbumin and oleic acid whose structural and functional contributions to HAMLET remain largely undefined. Results:The protonation state and function of the lipid are elucidated. Conclusion: HAMLET and oleate possess unique and overlapping effects on tumor cells. Significance: Unfolded proteins, like ␣-lactalbumin, form novel functional entities with deprotonated fatty acids.

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Section: Methodsmentioning

confidence: 99%

Lipids as Tumoricidal Components of Human α-Lactalbumin Made Lethal to Tumor Cells (HAMLET)

Storm

Rydström

et al. 2013

Journal of Biological Chemistry

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“…There a numerical lens was also introduced to focus the image at varying distances. High resolution microscopy is possible using a relatively simple setup [100,101], and a detailed analysis of image formation in lensless digital Fourier holography is given in Ref. 91.…”

Section: Fourier Holographymentioning

confidence: 99%

Principles and techniques of digital holographic microscopy

2010

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Abstract. Digital holography is an emerging field of new paradigm in general imaging applications. We present a review of a subset of the research and development activities in digital holography, with emphasis on microscopy techniques and applications. First, the basic results from the general theory of holography, based on the scalar diffraction theory, are summarized, and a general description of the digital holographic microscopy process is given, including quantitative phase microscopy. Several numerical diffraction methods are described and compared, and a number of representative configurations used in digital holography are described, including off-axis Fresnel, Fourier, image plane, in-line, Gabor, and phase-shifting digital holographies. Then we survey numerical techniques that give rise to unique capabilities of digital holography, including suppression of dc and twin image terms, pixel resolution control, optical phase unwrapping, aberration compensation, and others. A survey is also given of representative application areas, including biomedical microscopy, particle field holography, micrometrology, and holographic tomography, as well as some of the special techniques, such as holography of total internal reflection, optical scanning holography, digital interference holography, and heterodyne holography. The review is intended for students and new researchers interested in developing new techniques and exploring new applications of digital holography. C 2010 Society of Photo-Optical Instrumentation Engineers.

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“…It can be used to image solid samples in reflection, or, which is most common in the case of biological samples, to image transparent samples in transmittance. The most commonly used system for DHM today uses an optical setup common to that of a Mach-Zender interferometer, but with the reference light at a slight angle to the light passing through the sample, and the image calculation is then performed using a Fresnel approximation (Cuche et al, 1999) Varieties of the setup exist (Popescu et al, 2006;Gustafsson et al, 2004) and it is also sometimes given different names (Ikeda et al, 2005). There are also variations in the calculation of the actual recognizable image.…”

Section: Why Digital Holographic Microscopy?mentioning

confidence: 99%