High-resolution CT findings of diffuse bronchioloalveolar carcinoma in 38 patients.

Akira, Masanori; Atagi, Shinji; Kawahara, Masami; Iuchi, Keiji; Johkoh, Takeshi

doi:10.2214/ajr.173.6.10584811

Cited by 119 publications

(78 citation statements)

References 20 publications

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“…Multifocal and, sometimes, multilobar solid and subsolid nodules, which tend to be centrilobular or bronchocentric, are often observed (7,8). The radiographic findings …”

Section: Discussionmentioning

confidence: 99%

Invasive Mucinous Adenocarcinoma Mimicking Organizing Pneumonia Associated with <i>Mycobacterium fortuitum</i> Infection

et al. 2014

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We herein report the case of a 68-year-old man diagnosed with invasive mucinous adenocarcinoma of the lungs. Chest computed tomography showed subpleural ground-glass opacity and small nodules with cavitation. A culture of the bronchoalveolar lavage fluid resulted in the detection of Mycobacterium fortuitum. The patient's lung consolidation rapidly progressed; however, repeated bronchoscopy showed no atypical cells, thus suggesting a diagnosis of organizing pneumonia associated with M. fortuitum infection. However, the surgical biopsy specimen was diagnostic for adenocarcinoma, with no mycobacterial infection. Invasive mucinous adenocarcinoma should not be excluded in the differential diagnosis of patients with clinical features of organizing pneumonia and nontuberculous mycobacterium infection, even if a transbronchial biopsy confirms the absence of malignancy.

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“…Multifocal and, sometimes, multilobar solid and subsolid nodules, which tend to be centrilobular or bronchocentric, are often observed (7,8). The radiographic findings …”

Section: Discussionmentioning

confidence: 99%

Invasive Mucinous Adenocarcinoma Mimicking Organizing Pneumonia Associated with <i>Mycobacterium fortuitum</i> Infection

et al. 2014

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“…A pictorial review of IMA elucidated the typical CT findings, such as consolidation, ground-glass opacity and nodules (5)(6)(7)(8). The bubble-like lucency of pseudocavitation formation in the consolidation or nodule was also a major finding, which was observed in 40-78% of IMA cases (5)(6)(7)(8). By contrast, a thin-walled cystic lesion, particularly a large cyst, is rare.…”

Section: Discussionmentioning

confidence: 98%

Invasive mucinous adenocarcinoma of the lung presenting as a large, thin-walled cyst: A case report and literature review

Masuzawa

Minematsu

Sasaki

et al. 2017

Molecular and Clinical Oncology

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Abstract. Invasive mucinous adenocarcinoma (IMA), formerly referred to as mucinous bronchioloalveolar carcinoma, is a rare variant form of invasive adenocarcinoma and is radiologically characterized by dense pneumonic consolidation, ground-glass opacity and nodules. By contrast, large, thin-walled cysts are rare. We herein report the case of a 75-year-old man with IMA presenting as a large, irregularly shaped cystic lesion. The histological diagnosis was based on specimens obtained during a bronchoscopy. The patient underwent lobectomy followed by anticancer chemotherapy for residual intrapulmonary metastases. Of note, the small metastatic nodules transformed into cystic lesions with thin walls and fused, forming a large, multiloculated cystic lesion. Typical pneumonic consolidation appeared in the pericystic parenchyma later during the clinical course. The available literature on this rare radiological manifestation was also reviewed and discussed. Clinicians should be aware of thin-walled cystic lesions as they may be an unusual radiological finding in IMA. IntroductionInvasive mucinous adenocarcinoma (IMA), formerly referred to as mucinous bronchioloalveolar carcinoma, is distinct from non-mucinous adenocarcinoma and has been re-classified as a variant of invasive adenocarcinoma in the International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society lung adenocarcinoma classification system, due to its distinct clinical, radiological and pathological characteristics, as well as its distinct genetic background (frequent KRAS mutations) (1). The typical computed tomography (CT) findings in IMA include pneumonic consolidation, ground-glass opacity and nodules; by contrast, cystic lesions are rare. We herein describe a rare case of IMA presenting as a large cystic lesion. Case reportA 75-year-old man was admitted to the Hino Municipal Hospital due to a productive cough and mucous sputum lasting for 6 months. The patient had no previous illness or history of cigarette smoking. A chest radiograph obtained on admission revealed infiltration in the lower lobe of the right lung. A chest CT scan revealed an irregularly shaped cystic lesion comprising thin walls in the lower lobe of the right lung (9 cm in maximum diameter) and a mixed, dense and ground-glass opacity occupying a portion of the pericystic parenchyma (Fig. 1A, C and E). The tissue specimens obtained during bronchoscopy revealed non-specific inflammatory findings, without any neoplasm or vasculitis. The tissue culture was positive for Streptococcus anginosus. As treatment with antibiotics was ineffective, the CT scan was repeated one and a half months later, showing a rapid increase in the size of the cyst and progression of the parenchymal opacity in the lower lobe of the patient's right lung (Fig. 1B, D and F). In addition, centriacinar small nodules, some of which were cystic, appeared in the right middle and left upper lobes. The second-chance bronchoscopy revealed an atypical epithelium with abundant cytopl...

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“…Öncesinde multisentrik bronkioloalveoler karsinom olarak bilinen tablo, son değişikliklerle multifokal IMA olarak tanımlanmıştır. Radyolojik olarak çoğunlukla, ağırlıklı olarak akciğerlerin alt kesimlerinde, multilobar yerleşimli, konsolidasyon, nodül ya da kitle görünümünde sentrilobüler veya bronkosentrik lezyonlar olarak gelişirler [23] (Resim 7).…”

Section: Adenokarsinomunclassified

Akciğer Kanserinde Radyolojik Bulgular

Balci¹,

Altay²

2015

Trd Sem

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Akciğer kanserinin yerleşim yerine göre görüntüleme bulgularının öğrenilmesi Akciğer kanserinin histolojik tiplerine göre görüntüleme bulgularının öğrenilmesiAkciğer kanseri ve neden olduğu ölümlerin sıklığı, sigara içiciliğindeki artışa bağlı olarak 1930'lu yıllardan itibaren hızlı bir ivme gös-termiştir [1]. Sigara içiciliği akciğer kanseri için en önemli risk faktörüdür, ancak radon ve asbest maruziyeti de patogenezde rol almaktadır [2]. Günümüzde, doğrudan sigara ile ilişkili olarak en yüksek oranda (%80-85) ölüme neden olan kanser türüdür. Dünya genelinde erkeklerde en sık (33,8/100.000), kadınlarda ise en sık dördüncü (13,5/100.000) kanser tipidir [3]. Beş yıllık sağkalım oranı %16 olarak bildirilmektedir [2].Primer akciğer kanserleri genel olarak küçük hücreli akciğer kanseri (KHAK) ve küçük hüc-reli dışı akciğer kanseri (KHDAK) olarak iki alt gruba ayrılmaktadır. Küçük hücreli dışı akciğer kanseri; adenokarsinom, skuamöz hücreli akciğer kanseri, büyük hücreli akciğer kanseri ve diğer nadir alt tiplerini kapsamaktadır. Küçük hücreli dışı akciğer kanseri tüm akciğer kanserlerinin yaklaşık %85'ini oluşturur. Küçük hüc-reli akciğer kanseri, KHDAK tiplerine oranla klinik olarak daha kötü seyirlidir, erken dönem-de bölgesel lenf nodu ve uzak metastaz yapma sıklığı daha yüksektir [4,5]. Görüntüleme BulgularıAkciğer kanseri açısından klinik şüphe ya da anormal radyografi ileri inceleme gerektirir. Bilgisayarlı tomografi (BT) temel görüntüleme yöntemidir. Pozitron emisyon tomografi (PET) daha çok evreleme amaçlı olarak kullanılırken, manyetik rezonans (MR) problem çözücü yön-tem olarak bu alanda yer alır.Akciğer kanserlerinin yerleşim yeri ve hücre-sel alt tipe göre görüntüleme özellikleri değiş-mektedir.

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High-resolution CT findings of diffuse bronchioloalveolar carcinoma in 38 patients.

Cited by 119 publications

References 20 publications

Invasive Mucinous Adenocarcinoma Mimicking Organizing Pneumonia Associated with <i>Mycobacterium fortuitum</i> Infection

Invasive Mucinous Adenocarcinoma Mimicking Organizing Pneumonia Associated with <i>Mycobacterium fortuitum</i> Infection

Invasive mucinous adenocarcinoma of the lung presenting as a large, thin-walled cyst: A case report and literature review

Akciğer Kanserinde Radyolojik Bulgular

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