High-resolution computed tomography of the lungs: the borderlands of normality

Dalal, Paras; Hansell, David M.

doi:10.1007/s00330-005-0040-1

Cited by 17 publications

(7 citation statements)

References 59 publications

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“…Conversely, the increasing use of HRCT has led to situations in which limited features of ILD are seen in patients in whom the clinical significance is unclear. In some cases these changes may be within the limits of normality 161. It has been reported that approximately one-third of smokers have parenchymal changes such as patchy ground glass opacification and centrilobular nodules without obvious symptomatic or functional correlates 162 163.…”

Section: High Resolution Computed Tomography (Hrct)mentioning

confidence: 99%

Interstitial lung disease guideline

Wells

Hirani

2008

Thorax

590

223

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Section: High Resolution Computed Tomography (Hrct)mentioning

confidence: 99%

Interstitial lung disease guideline

Wells

Hirani

2008

Thorax

590

223

View full text Add to dashboard Cite

“…52 It has been suggested that air trapping reflects small-airway obstruction by peribronchiolar or intraluminal granulomas. However, it should be stressed that expiratory air trapping is a nonspecific HRCT sign that is not infrequent in healthy subjects 71 ; thus the clinical significance of limited mosaic attenuation is often difficult to interpret.…”

Section: Typical Parenchymal Lesions and Patternsmentioning

confidence: 99%

Imaging in Sarcoidosis

Nunès

Brillet

Valeyre

et al. 2007

Semin Respir Crit Care Med

149

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Sarcoidosis is a multisystemic granulomatous disease of unknown etiology that may involve virtually any organ. Pulmonary involvement predominates, but sarcoidosis can involve multiple organs, with or without concomitant lung involvement. Aberrations on chest radiographs are present in more than 90% of patients with sarcoidosis. Bilateral hilar lymphadenopathy, with or without lung parenchymal infiltrates, is typical but a wide range of chest radiographic patterns may be observed. This article discusses the characteristic chest radiographic features of sarcoidosis and the prognostic value of the radiographic staging classification as espoused by Scadding more than 4 decades ago. Thin-section high-resolution computed tomographic (HRCT) scans more clearly elucidate the intrathoracic lesions observed in sarcoidosis and may discriminate active inflammation from end-stage fibrosis. Although HRCT is not necessary to manage all cases of sarcoidosis, HRCT may be invaluable in SELECTED patients with stage II or III sarcoidosis to discriminate alveolitis (which may be amenable to therapy) from fibrosis. Additionally, radionuclide techniques may have a role in extrapulmonary sarcoidosis (particularly when central nervous system or cardiac involvement is suspected). We review the salient features and role of magnetic resonance imaging and diverse radionuclide techniques to diagnose or follow selected cases of extrapulmonary sarcoidosis.

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“…By measuring the lumen area (LA) and wall area (WA) of the bronchi using computed tomography (CT), it is possible to assess the airways function and structure [1][2][3]. These measurements allow a non-invasive monitoring of asthma [4], complementary to clinical and functional tests.…”

Section: Introductionmentioning

confidence: 99%

Quantification of bronchial dimensions at MDCT using dedicated software

et al. 2006

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This study aimed to assess the feasibility of quantification of bronchial dimensions at MDCT using dedicated software (BronCare). We evaluated the reliability of the software to segment the airways and defined criteria ensuring accurate measurements. BronCare was applied on two successive examinations in 10 mild asthmatic patients. Acquisitions were performed at pneumotachographically controlled lung volume (65% TLC), with reconstructions focused on the right lung base. Five validation criteria were imposed: (1) bronchus type: segmental and subsegmental; (2) lumen area (LA)>4 mm2; (3) bronchus length (Lg) > 7 mm; (4) confidence index - giving the percentage of the bronchus not abutted by a vessel - (CI) >55% for validation of wall area (WA) and (5) a minimum of 10 contiguous cross-sectional images fulfilling the criteria. A complete segmentation procedure on both acquisitions made possible an evaluation of LA and WA in 174/223 (78%) and 171/174 (98%) of bronchi, respectively. The validation criteria were met for 56/69 (81%) and for 16/69 (23%) of segmental bronchi and for 73/102 (72%) and 58/102 (57%) of subsegmental bronchi, for LA and WA, respectively. In conclusion, BronCare is reliable to segment the airways in clinical practice. The proposed criteria seem appropriate to select bronchi candidates for measurement.

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High-resolution computed tomography of the lungs: the borderlands of normality

Cited by 17 publications

References 59 publications

Interstitial lung disease guideline

Interstitial lung disease guideline

Imaging in Sarcoidosis

Quantification of bronchial dimensions at MDCT using dedicated software

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