High Remnant Cholesterol Level Potentiates the Development of Hypertension

Abstract

BackgroundEmerging evidence suggests an association between remnant cholesterol (RC) and vascular damage and hypertension. However, this association has not been explored in a large-scale population in China, and a temporal relationship between RC and hypertension also needs to be investigated.MethodsWe conducted a retrospective cross-sectional study in 2,199,366 individuals and a longitudinal study in 24,252 individuals with repeated measurements of lipid profile and blood pressure in at least a 3-year follow-up. The logistic model was used to explore the association between lipid components and hypertension in the cross-sectional analysis. The Cox model was used to analyze the association between high RC (HRC) at baseline and the subsequent incidence of hypertension or the association between hypertension at baseline and incidence of HRC. The cross-lagged panel model was applied to analyze the temporal relationship between RC and hypertension.ResultsRC level as a continuous variable had the highest correlation with hypertension among lipid profiles, including RC, low-density lipoprotein cholesterol, total cholesterol, non-high-density lipoprotein cholesterol, and triglycerides, with an odds ratio of 1.59 (95% confidence interval: 1.58–1.59). In the longitudinal cohort, HRC at baseline was associated with incident hypertension. We further explored the temporal relationship between RC and hypertension using the cross-lagged analysis, and the results showed that RC increase preceded the development of hypertension, rather than vice versa.ConclusionsRC had an unexpected high correlation with the prevalence and incidence of hypertension. Moreover, RC increase might precede the development of hypertension, suggesting the potential role of RC in the development of hypertension.

Remnant cholesterol is a risk factor for metabolic syndrome and cardiovascular disease: a cross-sectional study

“…Additionally, a study of a population of 7308 individuals recruited from CHNS showed that the concentration of RC was associated with DM beyond the LDL-C [30]. Besides, RC also had a substantial connection with the prediction or diagnosis of hypertension, and could be used as a blood marker for screening [31,32]. All of the above evidence indicated that RC level was highly relevant to cardiometabolic disorders.…”

The Association of Remnant Cholesterol with Endothelial Dysfunction and Subclinical Atherosclerosis in a Check-Up Population in China

“…Adverse cardiovascular events related to RC have also been observed in many clinical studies. High levels of RC have been reported to be associated with an increased risk of coronary artery disease, fatty liver disease, hypertension, and chronic kidney disease 11,12,[33][34][35] . FMD, which is a marker of endothelium-dependent dilation of the brachial artery, reflects systemic endothelial function, as well as atherosclerotic risk burden at the time of FMD measurement.…”

Interaction between SIDT2 and ABCA1 Variants with Nutrients on HDL-c Levels in Mexican Adults

“…We could speculate that there is a potential biological interaction. SIDT2 is an integral membrane protein associated with cholesterol uptake from the extracellular space into the cell via endocytosis [ 59 ]. The binding to cholesterol by the SIDT2 protein is performed specifically by the transmembrane Cholesterol Recognition/interaction Amino acid Consensus (CRAC) domain.…”