High Recovery Rate of Non-albicans Candida Species Isolated From Burn Patients With Candidemia in Iran

Lotfi, Nazanin; Shokohi, Tahereh; Nouranibaladezaei, Seyed Zahra; Omran, Ayatollah Nasrolahi; Kondori, Nahid

doi:10.5812/jjm.22929

Cited by 18 publications

(20 citation statements)

References 27 publications

(30 reference statements)

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“…Lotfi et al reported C. parapsilosis and C. tropicalis as the most common Candida species isolated from burn patients with candidemia [17]. Inconsistent with their finding, C. albicans was the most common cause of candidemia found in this study.…”

Section: Discussionsupporting

confidence: 76%

Candidemia in patients with prolonged fever in Kashan, Iran

et al. 2016

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Background and Purpose: Candida species are considered a common cause of fungal blood stream infections, which are associated with considerable mortality and morbidity rates, especially in the admitted and immunocompromised patients. Despite the increase in new and available antifungal agents, the emergence of resistant strains is growing. Regarding this, the aim of the present study was to assess the fungal epidemiology of candidemia and the antifungal susceptibility patterns against five current antifungal agents among the patients with prolonged fever, who were admitted to Beheshti Educational Hospital, Kashan, Iran.Materials and Methods:This cross-sectional study was conducted on 253 hospitalized patients with prolonged fever despite receiving broad-spectrum antibiotic therapy. Blood samples were collected aseptically, and then cultured using an automated blood culture system and conventional broth culture bottle. Candida isolates were identified at species level using morphological and physiological properties and produced color on the CHROMagar Candida. Furthermore, the antifungal susceptibility testing was performed using (CLSI M27-A3 and CLSI M27-S4) broth microdilution methods.Results:The most positive cultures were detected by the automated blood culture system. C. albicans (%50) was the most prevalent species, followed by C. glabrata (%40), and C. parapsilosis, (%10) respectively .The mortality rate was high (%60) and most patients with candidemia were admitted to the Intensive Care Unit and Neonatal Intensive Care Unit. All isolates were susceptible to amphotericin B, while the highest resistance belonged to caspofungin.Conclusion:In this study, high resistance was reported, especially for caspofungin, which can be regarded as the emergence of caspofungin-resistant strains. Regarding this, the establishment of a surveillance and prevention program for the reduction of the emergence of resistant species is necessary.

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Section: Discussionsupporting

confidence: 76%

Candidemia in patients with prolonged fever in Kashan, Iran

et al. 2016

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“…In epidemiological studies, most of the yeast isolates belong to Candida species, especially C. albicans (1,4,5,17,18). Previous studies in different regions of Iran show that Candida species were isolated from various clinical samples rather than other yeasts (2,5,(18)(19)(20)(21)(22)(23). As already mentioned in most studies, among Candida species, C. albicans, C. parapsilosis, C. tropicalis, C. glabrata, and C. krusei were the most common causes of candidiasis in Iran.…”

Section: Discussionmentioning

confidence: 99%

Molecular Identification of Clinically Common and Uncommon Yeast Species

Shokohi

Moradi

Badram

et al. 2018

Jundishapur J Microbiol

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Background: The incidence of fungal infections caused by the yeasts and yeast-like species increased dramatically in immunocompromised patients, during the past several decades. However, a few of yeast and yeast-like species may colonize in skin and mucous membranes of healthy individuals. Objectives: The current study aimed at accurately identifying yeast and yeast-like species from clinical samples by molecular methods. Methods: A total of 1200 clinical samples were collected from patients with suspected fungal infection and 110 (9.16 %) yeast and yeast-like strains isolated and identified by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), PCR amplification of hwp1 gene, and sequencing. Results: In total, Candida albicans (n = 46) was the most frequently isolated species followed by C. parapsilosis complex (n = 17), C. tropicalis (n = 13), C. guilliermondii (n = 12), C. glabrata (n = 4), C. krusei and C. famata each (n = 3), C. kefyr, C. haemulonii and Cutaneotrichosporon jirovecii each (n = 2), and C. stellatoidea, C. intermedia, C. sorbosivorans, C. africana, Pichia kudriavzevii, and Trichosporon asahii each (n = 1). Interestingly, C. haemulonii, a multidrug resistant fungus was isolated from cutaneous and sputum samples for the first time in Iran. Conclusions: Nowadays, with growing population at risk for fungal infections and the emergence of some less virulent or nonpathogenic and uncommon yeasts not readily distinguishable with phenotypic assays, the accurate identification using molecular methods are warranted.

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“…Candida could invade blood stream in burn patients, which has been associated with high mortality and a prolonged hospital stay. Nonalbicans Candida was found to be a significant pathogens in burned patients with candidemia [13]. Fungi might also invade deep tissue and blood stream.…”

Section: Editorialmentioning

confidence: 99%

Fungal Burn Wound Infection

Mousa¹

2016

Fungal Genom Biol

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High Recovery Rate of Non-albicans Candida Species Isolated From Burn Patients With Candidemia in Iran

Cited by 18 publications

References 27 publications

Candidemia in patients with prolonged fever in Kashan, Iran

Candidemia in patients with prolonged fever in Kashan, Iran

Molecular Identification of Clinically Common and Uncommon Yeast Species

Fungal Burn Wound Infection

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