High ratio of C-reactive protein/procalcitonin predicts
            <i>Mycoplasma pneumoniae</i>
            infection among adults hospitalized with community acquired pneumonia

Li, Fuxing; Kong, Shan; Xie, Kexin; Zhang, Yulin; Yan, Ping; Zhao, Weidong

doi:10.1080/00365513.2020.1858491

Cited by 12 publications

(10 citation statements)

References 21 publications

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“…The use of an elevated CRP to procalcitonin ratio as a predictor for M pneumonia in adults has been explored, but evidence in pediatric cases is still limited. [52–54]…”

Section: Discussionmentioning

confidence: 99%

“…The use of an elevated CRP to procalcitonin ratio as a predictor for M pneumonia in adults has been explored, but evidence in pediatric cases is still limited. [52][53][54] Following the widespread use of pneumococcal conjugate vaccines, M pneumoniae has emerged as the predominant bacterial culprit in lower respiratory tract infections in children. [55] Currently, there is no vaccine available to prevent M pneumoniae infections, but a variety of MP vaccines are under development, including whole-cell vaccines (inactivated and live-attenuated vaccines), subunit vaccines (involving M pneumoniae protein P1, protein P30, protein P116 and CARDS toxin) and DNA vaccines.…”

Section: Hotspots and Frontiersmentioning

confidence: 99%

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Research status and challenges of Mycoplasma pneumoniae pneumonia in children: A bibliometric and visualization analysis from 2011 to 2023

Liu,

Wang,

et al. 2024

Medicine

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Background: Mycoplasma pneumoniae (MP) infections occur in regional outbreaks every 3 to 7 years, lasting up to 2 years. Since this fall, there has been a significant rise in MP infections among children in China, indicating a regional epidemiological trend that imposes an increased national public health burden. To date, bibliometric methods have not been applied to studies on MP infection in children. Methods: We searched for all relevant English publications on MP pneumonia in children published from 2011 to 2023 using Web of Science. Analytical software tools such as Citespace and VOSviewer were employed to analyze the collected literature. Results: 993 articles on MP pneumonia in children were published in 338 academic journals by 5062 authors affiliated with 1381 institutions across 75 countries/regions. China led in global productivity with 56.19%. Among the top 10 prolific organizations, 8 were Chinese institutions, with Soochow University being the most active, followed by Capital Medical University and Zhejiang University. Zhimin Chen from Zhejiang University School of Medicine exhibited the highest H-index of 32. Keyword co-occurrence network analysis revealed 7 highly relevant clusters. Conclusion: The current research hotspots and frontiers in this field are primarily MP pneumonia, refractory MP pneumonia, lactate dehydrogenase, asthma, and biomarker. We anticipate that this work will provide novel insights for advancing scientific exploration and the clinical application of MP pneumonia in children.

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“…The use of an elevated CRP to procalcitonin ratio as a predictor for M pneumonia in adults has been explored, but evidence in pediatric cases is still limited. [52–54]…”

Section: Discussionmentioning

confidence: 99%

Section: Hotspots and Frontiersmentioning

confidence: 99%

Research status and challenges of Mycoplasma pneumoniae pneumonia in children: A bibliometric and visualization analysis from 2011 to 2023

Liu,

Wang,

et al. 2024

Medicine

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“…Several studies have shown that blood inflammatory biomarkers, such as procalcitonin and CRP, can assist in differentiating between bacterial and viral CAP ( 28 , 29 ). In recent years, platelets have been found to detect endothelial cell damage and pathogenic microorganism invasion, forming the first line of defense against pathogenic infections ( 30 ).…”

Section: Discussionmentioning

confidence: 99%

Dynamics of platelet parameters in children with severe community-acquired pneumonia between viral and bacterial infections

Fan,

Mao,

Liu

et al. 2024

Transl Pediatr

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Background Changes in platelet parameters may vary according to the different pathogens. However, little is known about the differences in platelet parameters in children with severe community-acquired pneumonia (CAP) children of viral and bacterial infections. Methods This was a single-center retrospective study that included 156 children with severe CAP. Dynamic changes in platelet parameters, including platelet count (PLT), mean platelet volume (MPV), platelet distribution width (PDW) and plateletcrit (PCT), were recorded at 24 h, 48 h, 72 h, and day 7 of admission, as well as at discharge. Results At 72 h of admission, PLT in the viral infection group was significantly lower than that in the bacterial infection and bacterial and viral coinfections group. Meanwhile, the curve of changes in PLT (ΔPLT) in the viral infection group was clearly separated from the other two groups at this time point. Receiver operating characteristic (ROC) analysis showed that PLT at 72 h of admission could assist in distinguishing bacterial and viral infections in severe pneumonia children with the area under curve (AUC) value of 0.683 [95% confidence interval (CI): 0.561–0.805, P=0.007]. However, its sensitivity and specificity were not high, at 68% and 65%, respectively. Conclusions Although the diagnostic value of platelet parameters in bacterial and viral infection in children with severe CAP is limited, they are still expected to be combined with other indicators to provide a reference for timely treatment.

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“…CRP was a non-specific marker of inflammation, which could rapidly increase within 4–6 h of infection. Its elevation was positively related to the degree of infection and inflammatory response ( 19 ). In our study, it is also shown that SMPP patients have higher CRP level than NSMPP patients (21 vs. 15), but not as high as an infection of bacteria.…”

Section: Discussionmentioning

confidence: 99%

D-dimer: The Risk Factor of Children's Severe Mycoplasma Pneumoniae Pneumonia

2022

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ObjectiveMycoplasma Pneumoniae (MP) is an important cause of community-acquired pneumonia in children, which can cause serious consequences. There has been some research into predicting Severe Mycoplasma Pneumoniae Pneumonia (SMPP) primarily focused on pre-treatment time by macrolide, pre-hospital course, CRP and LDH et.al. while seldom reporting on concoagulation status. We designed this retrospective study to compare the difference between SMPP and Non-severe MPP (NSMPP) with an attempt to find the risk factors, with a special focus on concoagulation status.MethodWe performed a retrospective study of 786 MPP patients who were hospitalized from January 1, 2016 to December 31, 2018, age ranging from 28 days to 18 years old. All patients were divided into SMPP group and NSMPP group. A univariate analysis was conducted between both groups. The factors with statistical differences were included in logistic regression analysis to summarize the predictors of SMPP. Next, the predictive value of each risk factor was calculated from the receiver operating characteristic curve (ROC curve). Patients who had D-dimer records were divided into the elevated D-dimer group (D-dimer > 308ug/L) and the control group (D-dimer ≤ 308ug/L), and the clinical manifestations were compared.ResultsThere was no significant difference in gender, age, pre-treatment time by macrolide, the white blood cell counts (WBC), Fibrinogen (FIB), Activated Partial Prothrombin Time (APTT), Prothrombin Time (PT) and Thrombin Time (TT) between SMPP and NSMPP. Compared with NSMPP, the pre-hospital course of SMPP was longer (P < 0.05), the neutrophil ratio (N%), platelet Count (PLT), C-reactive Protein (CRP), Lactate Dehydrogenase (LDH) and D-dimer were significantly higher (P < 0.01). The binary logistic regression analysis showed that the N%, PLT, CRP, LDH and D-dimer were the key predictors for SMPP, the N% > 67%, OR = 3.233, PLT > 445 × 109 /L, OR = 2.589, LDH > 354U/L, OR = 4.335 and D-dimer level > 403 ug/L, OR = 7.316. The D-dimer possessed the best predictive value. The incidence of complications such as pleural effusion, myocardial and liver damage of MPP was higher in the elevated D-dimer group than that in the control group (P < 0.05).ConclusionThe N%, PLT, CRP, LDH and D-dimer were risk factors for SMPP. D-dimer was the best predictor among them. MPP patients with D-dimer > 308ug/L had more complications such as pleural effusion, myocardial and liver damage. More attention should be given in the treatment for this group.

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High ratio of C-reactive protein/procalcitonin predicts Mycoplasma pneumoniae infection among adults hospitalized with community acquired pneumonia

Cited by 12 publications

References 21 publications

Research status and challenges of Mycoplasma pneumoniae pneumonia in children: A bibliometric and visualization analysis from 2011 to 2023

Research status and challenges of Mycoplasma pneumoniae pneumonia in children: A bibliometric and visualization analysis from 2011 to 2023

Dynamics of platelet parameters in children with severe community-acquired pneumonia between viral and bacterial infections

D-dimer: The Risk Factor of Children's Severe Mycoplasma Pneumoniae Pneumonia

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