High Rates of Osteoarthritis Develop After Anterior Cruciate Ligament Surgery: An Analysis of 4108 Patients

Cinque, Mark E.; Dornan, Grant J.; Chahla, Jorge; Moatshe, Gilbert; LaPrade, Robert F.

doi:10.1177/0363546517730072

Cited by 145 publications

(140 citation statements)

References 64 publications

(45 reference statements)

Supporting

Mentioning

127

Contrasting

Unclassified

Order By: Relevance

“…Osteoarthritis (OA) is a disease of the whole joint, affecting the functional unit of articular cartilage, subchondral bone, and synovium . Post‐traumatic OA (PTOA), OA that occurs after a joint injury such as an anterior cruciate ligament (ACL) tear, has an incidence of over 50% at 20 years after ACL tear and reconstruction . While biomechanical stress on the joint is well accepted as an etiologic factor in the development of PTOA, the cell signaling and biochemical factors involved in its pathogenesis are less appreciated.…”

mentioning

confidence: 99%

“…1,2 Post-traumatic OA (PTOA), OA that occurs after a joint injury such as an anterior cruciate ligament (ACL) tear, has an incidence of over 50% at 20 years after ACL tear and reconstruction. 3,4 While biomechanical stress on the joint is well accepted as an etiologic factor in the development of PTOA, 5 the cell signaling and biochemical factors involved in its pathogenesis are less appreciated. The initial inflammatory response after injury, generally thought to be important for healing in the body, 6 may also be harmful to the long-term health of articular cartilage and subchondral bone.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Acute Changes in NADPH Oxidase 4 in Early Post‐Traumatic Osteoarthritis

Wegner

Campos

Robbins

et al. 2019

Journal Orthopaedic Research

View full text Add to dashboard Cite

Knee injuries cause structural damage and acute inflammation that initiates the development of post‐traumatic osteoarthritis (PTOA). NADPH oxidase 4 (Nox4), a member of a family of enzymes that generates reactive oxygen species (ROS), plays a pivotal role in normal development of the musculoskeletal system, but may increase ROS production to harmful levels after joint injury. The role of ROS in both normal joint homeostasis and injury is poorly understood, but inhibition of excessive ROS production by Nox4 after joint injury could be protective to the joint, decreasing oxidative stress, and initiation of PTOA. Knee injuries were simulated using inflammatory cytokines in cultured primary human chondrocytes and a non‐invasive mouse model of PTOA in C57BL/6N and Nox4 knockout mice. There is an acute decrease in Nox4 activity within 24 h after injury in both systems, followed by a subsequent sustained low‐level increase, a novel finding not seen in any other system. Inhibition of Nox4 activity by GKT137831 was protective against early structural changes after non‐invasive knee injury in a mouse model. Nox4 knockout mice had significant differences in structural and mechanical properties of bone, providing further evidence for the role of Nox4 in development of joint tissues and biochemical response after joint injury. Nox4 plays a significant role in the acute phase after joint injury, and targeted inhibition of inflammation caused by Nox4 may be protective against early joint changes in the pathogenesis of PTOA. © 2019 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 37:2429–2436, 2019

show abstract

mentioning

confidence: 99%

mentioning

confidence: 99%

Acute Changes in NADPH Oxidase 4 in Early Post‐Traumatic Osteoarthritis

Wegner

Campos

Robbins

et al. 2019

Journal Orthopaedic Research

View full text Add to dashboard Cite

show abstract

“…8 Additionally, ACL tears are frequently associated with meniscal injury which has been previously demonstrated to increase the risk of developing PTOA from 16.4 to 50.4%, with joint space narrowing noted as early as 2 years despite meniscal repair. 9,10 Although it has been estimated that 12% of cases of symptomatic OA are secondary to traumatic joint injury, this may underestimate that rate at which PTOA occurs in the military population. 11 As demonstrated by high rates of ACL tears, as well as other intra-articular pathologies and periarticular fractures, military service members experience acute traumatic joint injuries at a much greater rate than their civilian counterparts.…”

Section: Osteoarthritis In the Militarymentioning

confidence: 99%

Primary and Posttraumatic Knee Osteoarthritis in the Military

2019

View full text Add to dashboard Cite

Osteoarthritis is a particularly burdensome and career-limiting condition for military service members. The daily demands of military service place the service members at a baseline increased risk of developing primary OA as well as increased risk of acute knee injuries that further predispose to developing posttraumatic OA. There are multiple treatment options available for primary and posttraumatic OA from osteotomy to arthroplasty.

show abstract

“…Anterior cruciate ligament (ACL) injury has received a lot of attention due to its potentially severe consequences regarding return-to-sport rates, re-injuries and osteoarthritis development 6,16,73,126 , even though it only represents about 5% of all time-loss injuries in football regardless of sex or playing level 175 . When comparing different sports, the ACL incidence rates were highest in football among girls 51,159 and in lacrosse and American football in boys 51,159 .…”

Section: Injury Surveillancementioning

confidence: 99%

Injury Prevention in Youth Football Players : Training Effects and Programme Implementation

Lindblom

2019

Linköping University Medical Dissertations

View full text Add to dashboard Cite

Background With 17-35% of all 14-year-olds in Sweden being active in football, injuries do occur, most frequently during match play. Based on knowledge of injury mechanisms and risk factors, different injury prevention exercise programmes (IPEPs) have been developed. In this thesis, the Swedish IPEP Knee Control was used as a model for injury preventive training. Aim The overall aim of this thesis was to improve our understanding of the effects of the Knee Control injury prevention exercise programme on sports performance and jump-landing technique, as well as exploring programme implementation and coach experiences of using the programme in youth football. Methods Studies I and IV were cluster-randomised trials focusing on the performance effects of Knee Control. Study I included four teams with 41 female youth football players (mean age 14). The intervention group used Knee Control twice weekly for 11 weeks, whereas the control group teams did their usual training. Knee Control includes six different exercises at four levels of difficulty and with partner exercises and is meant to be used during warm-up at every training session. Performance was tested using a battery of balance, agility, jump and sprint tests at baseline and follow-up at an indoor venue. Study IV had a similar setup but included two different interventions: Knee Control and a new, further-developed version of the programme, Knee Control+, which were studied during an eight-week intervention involving eight youth football teams, four male, four female (mean age 14), with 77 players. Similar, but not identical, performance tests were used in Study IV, along with drop vertical jumps and tuck jump assessment to assess jump-landing technique.

show abstract

High Rates of Osteoarthritis Develop After Anterior Cruciate Ligament Surgery: An Analysis of 4108 Patients

Cited by 145 publications

References 64 publications

Acute Changes in NADPH Oxidase 4 in Early Post‐Traumatic Osteoarthritis

Acute Changes in NADPH Oxidase 4 in Early Post‐Traumatic Osteoarthritis

Primary and Posttraumatic Knee Osteoarthritis in the Military

Injury Prevention in Youth Football Players : Training Effects and Programme Implementation

Contact Info

Product

Resources

About