High rates of atherogenic dyslipidemia, β-cell function loss, and microangiopathy among Turkish migrants with T2DM

Hermans, Michel P.; Ahn, Sylvie A.; Sadikot, Shaukat; Rousseau, Michel F.

doi:10.1016/j.dsx.2018.11.049

Cited by 5 publications

(4 citation statements)

References 16 publications

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“…Individuals with diabetes mellitus were twice as likely to have higher atherogenic index compared to those without this condition. These findings are consistent other study findings reporting correlations between type 2 diabetes and high atherogenic indices [35][36][37]. The proposed mechanism for the observed association is an increased oxidative stress and endothelia cell dysfunction [35].…”

Section: Discussionsupporting

confidence: 92%

Prevalence of and factors associated with high atherogenic index among adults in Nairobi urban informal settlements: The AWI-Gen study

Wambui

Mohamed²,

Asiki³

2022

PLOS Glob Public Health

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Dyslipidemia is an important cardiovascular disease predictor. Atherogenic index of plasma (AIP), a ratio of triglycerides (TG) to high density lipoprotein (HDL) cholesterol has been deemed to be more informative as a cardiovascular disease predictor compared to using any single predictor. The aim of this study was to explore the factors associated with elevated atherogenic index among people living in low-income urban areas of Nairobi, Kenya. Data used in this study were obtained from a cross-sectional population-based study with 2,003 participants conducted in Nairobi as part of the Africa Wits-INDEPTH Partnership for Genomic Research, AWI-Gen). Sociodemographic, behavioral, and clinical characteristics were collected from the participants. AIP was derived from the log of TG/HDL cholesterol and categorized into low risk (AIP<0.1), intermediate risk (AIP = 0.1–0.24) and high risk (AIP >0.24). Fifty-four percent (54%) of the study participants were women and the mean age of participants enrolled in this study was 48.8 years. Twenty-nine percent (29%) of study participants had high or medium atherogenic risk. Men, HIV patients, individuals with self-reported uncontrolled diabetes and obese individuals were at higher atherogenic risk. We have identified modifiable risk factors which can be addressed to reduce dyslipidemia in this population. Longitudinal studies may help to precisely determine how these factors relate with cardiovascular diseases.

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Section: Discussionsupporting

confidence: 92%

Prevalence of and factors associated with high atherogenic index among adults in Nairobi urban informal settlements: The AWI-Gen study

Wambui

Mohamed²,

Asiki³

2022

PLOS Glob Public Health

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“…Clinical studies have reported that T2DM could lead to atherosclerotic dyslipidemia [28], with increased TC, TG, and LDL-C and decreased HDL-C levels. The development of ischemic heart disease is positively associated with increased TC and TG levels and negatively associated with decreased HDL-C levels [12].…”

Section: Discussionmentioning

confidence: 99%

Hypoglycemic mechanism of Tegillarca granosa polysaccharides on type 2 diabetic mice by altering gut microbiota and regulating the PI3K-akt signaling pathwaye

Jiang¹,

Chen²,

Wang³

et al. 2024

Food Science and Human Wellness

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Type 2 diabetes mellitus (T2DM) is a complex metabolic disease threatening human health. We investigated the effects of Tegillarca granosa polysaccharide (TGP) and determined its potential mechanisms in a mouse model of T2DM established through a high-fat diet and streptozotocin. TGP (5.1×10 3 Da) was composed of mannose, glucosamine, rhamnose, glucuronic acid, galactosamine, glucose, galactose, xylose, and fucose. It could significantly alleviate weight loss, reduce fasting blood glucose levels, reverse dyslipidemia, reduce liver damage from oxidative stress, and improve insulin sensitivity. RT-PCR and western blotting indicated that TGP could activate the phosphatidylinositol-3-kinase/protein kinase B signaling pathway to regulate disorders in glucolipid metabolism and improve insulin resistance. TGP increased the abundance of Allobaculum, Akkermansia, and Bifidobacterium, restored the microbiota abundance in the intestinal tracts of mice with T2DM, and promoted short-chain fatty acid production. This study provides new insights into the antidiabetic effects of TGP and highlights its potential as a natural hypoglycemic nutraceutical.

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“…T2DM usually can cause dyslipidemia (Li et al., 2019), which is characterized by the accumulation of TG, TC, and LDL‐C in the blood (Huang et al., 2019). Blood lipid levels are important factors leading to cardiovascular disease in T2DM (Hermans et al., 2019). Compared with the DC group, dietary supplementation with RAB and CAB significantly reduced the levels of TC and LDL‐C in the serum of diabetic mice but had no effects on TG and HDL‐C (Figure 4).…”

Section: Discussionmentioning

confidence: 99%

Comparison of the effects of raw and cooked adzuki bean on glucose/lipid metabolism and liver function in diabetic mice

et al. 2021

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Background and objectives Diabetes is a serious metabolic disease. The present study investigated the ability of diets supplemented with raw and cooked adzuki bean to mitigate the effects of diabetes and related metabolic disorders in type 2 diabetic mice induced by a high‐fat diet combined with streptozotocin (STZ). Findings Compared with untreated diabetic mice, raw adzuki bean (RAB) supplementation significantly reduced food intake, glycated serum protein (GSP), and fasting blood glucose (FBG) and improved glucose tolerance. Cooked adzuki bean (CAB) supplementation cannot effectively improve FBG, but significantly reduce weight loss and GSP. In addition, adzuki bean supplementation significantly reduced low‐density lipoprotein cholesterol (LDL‐C) and total cholesterol (TC) levels. Histological observations confirmed the ability of adzuki bean supplementation to prevent pancreatic and liver damage. The content of total flavonoids and catechins in adzuki bean decreased significantly after processing. Conclusions Although RAB and CAB supplementation showed many beneficial impacts on type 2 diabetic mice, the lower efficacy of CAB is likely caused by a loss of bioactive substances from processing. Significance and novelty These findings may contribute to a better understanding of the benefits of adzuki bean as a dietary supplement to prevent type 2 diabetes mellitus (T2DM) and related metabolic disorders.

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High rates of atherogenic dyslipidemia, β-cell function loss, and microangiopathy among Turkish migrants with T2DM

Cited by 5 publications

References 16 publications

Prevalence of and factors associated with high atherogenic index among adults in Nairobi urban informal settlements: The AWI-Gen study

Prevalence of and factors associated with high atherogenic index among adults in Nairobi urban informal settlements: The AWI-Gen study

Hypoglycemic mechanism of Tegillarca granosa polysaccharides on type 2 diabetic mice by altering gut microbiota and regulating the PI3K-akt signaling pathwaye

Comparison of the effects of raw and cooked adzuki bean on glucose/lipid metabolism and liver function in diabetic mice

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