High rate of nickel allergy in women with endometriosis: A 3‐year population‐based study

Yuk, Jin‐Sung; Kim, Yong Jin; Yi, Kyong Wook; Kim, Tak; Hur, Jun Young; Shin, Jung Hoon

doi:10.1111/jog.12707

Cited by 10 publications

(14 citation statements)

References 19 publications

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“…Intestinal localization of endometriosis lesions increased visceral hypersensitivity, alterations of the myenteric plexus or the hormonal regulation may be considered [55]. Concerning IBS-like disorders, recent studies showed a higher rate of Ni allergy in endometriosis than in the control population [20]. On the other hand, since Ni omPT revealed to be more sensitive and specific than ePT in detecting adverse reactions to Ni-rich foods, the prevalence of Ni sensitivity in endometriosis may be even higher [5].…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, higher Ni concentrations have been found in serum and ectopic endometrial tissue from patients with endometriosis [19]. In addition, women with endometriosis already showed a slightly higher rate of Ni allergic contact dermatitis vs. control patients [20].…”

Section: Endometriosismentioning

confidence: 98%

“…Gastrointestinal symptoms in endometriosis may also be related to IBS or IBS-like disorders [45]. Recent studies showed a higher prevalence of Ni skin allergy in women with endometriosis, as well as a possible Ni involvement in its etiopathogenesis [20,46,47]. On these bases, it is possible to hypothesize that an IBS-like disorder, such as Ni ACM, may be the cause or contributing factor of gastrointestinal symptoms in women with endometriosis.…”

Section: Gastrointestinal Disorders and Endometriosismentioning

confidence: 99%

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Irritable Bowel Syndrome-Like Disorders in Endometriosis: Prevalence of Nickel Sensitivity and Effects of a Low-Nickel Diet. An Open-Label Pilot Study

et al. 2020

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Alimentary nickel (Ni) may result in allergic contact mucositis (ACM), whose prevalence is >30% and may present with IBS-like and extra-intestinal symptoms. These symptoms are also frequent in endometriosis, and Ni allergic contact dermatitis has already been observed in endometriosis. Therefore, intestinal and extra-intestinal symptoms in endometriosis may depend on a Ni ACM, and a low-Ni diet could improve symptoms. We studied the prevalence of Ni ACM in endometriosis and focused on the effects of a low-Ni diet on gastrointestinal, extra-intestinal, and gynecological symptoms. We recruited 84 women with endometriosis, symptomatic for gastrointestinal disorders. Thirty-one out of 84 patients completed the study. They underwent Ni oral mucosa patch test (omPT), questionnaire for intestinal/extra-intestinal/gynecological symptoms, and a low-Ni diet. Clinical evaluation was performed at baseline (T0) and after three months (T1). Twenty-eight out 31 (90.3%) patients showed Ni omPT positive results, with Ni ACM diagnosis, whereas three out of 31 (9.7%) patients showed negative Ni omPT. After three months of low-Ni diet, all gastrointestinal, extra-intestinal and gynecological symptoms showed a statistically significant reduction. Ni ACM has a high prevalence in endometriosis and a low-Ni diet may be recommended in this condition to reduce gastrointestinal, extra-intestinal and gynecological symptoms.

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Section: Discussionmentioning

confidence: 99%

Section: Endometriosismentioning

confidence: 98%

Section: Gastrointestinal Disorders and Endometriosismentioning

confidence: 99%

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Irritable Bowel Syndrome-Like Disorders in Endometriosis: Prevalence of Nickel Sensitivity and Effects of a Low-Nickel Diet. An Open-Label Pilot Study

et al. 2020

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“…Recently, one study showed that nickel concentrations in the blood of patients with endometriosis were higher than those in a control group [ 14 ]. More recently, Yuk et al reported a positive relationship between nickel allergy and endometriosis using a cross-sectional population-based study [ 7 ]. However, no previous study has evaluated the causal link between nickel allergy and endometriosis.…”

Section: Discussionmentioning

confidence: 99%

“…Recently, using national claims data in South Korea, Yuk et al demonstrated a high rate of nickel allergy in women with endometriosis [ 7 ]. Because nickel allergy involves features of environmental exposure and the immune response, there may be a relationship between nickel allergy and the pathogenesis of endometriosis [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Nickel Allergy Is a Risk Factor for Endometriosis: An 11-Year Population-Based Nested Case-Control Study

Yuk¹,

Shin²,

Shin³

et al. 2015

PLoS ONE

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BackgroundA cross-sectional study has reported that nickel allergy is associated with endometriosis. However, causal studies of this association are limited.ObjectiveThe objective of this study was to compare the prevalence of nickel allergy in women with and without endometriosis.MethodsWe used a National Health Insurance Service (NHIS) sample cohort dataset that included approximately 1 million individuals from South Korea; the data were obtained between January 01, 2002, and December 31, 2013. We selected the endometriosis group according to diagnosis code (N80.X), surgery codes, and drug codes during the years 2009~2013. The controls were randomly matched to the endometriosis patients at a ratio of 4:1 by age and socioeconomic status. Patients with nickel allergy were defined in the cohort dataset as those with a simultaneous diagnosis code (L23.0) and patch test code during 2002~2008.ResultsIn total, 4,985 women were selected from the NHIS cohort database and divided into an endometriosis group (997 women) and a control group (3,988 women). The number of patients with nickel allergy in the endometriosis group was eight (0.8%), and that in the control group was thirteen (0.3%). After adjustment for age and socioeconomic status, the rate of nickel allergy in was higher in the endometriosis group than in the control group [odds ratio: 2.474; 95% confidence interval: 1.023~5.988; p = 0.044].ConclusionsWe found that nickel allergy is a risk factor for endometriosis.

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Research in Benign Gynaecology

Gerval¹,

Panay²,

O’Brien³

et al. 2017

Introduction to Research Methodology for Specialists and Trainees

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High rate of nickel allergy in women with endometriosis: A 3‐year population‐based study

Abstract: Women with endometriosis had higher rates of nickel allergy. Further research is required to clarify the relation between nickel allergy and endometriosis.

Cited by 10 publications

References 19 publications

Irritable Bowel Syndrome-Like Disorders in Endometriosis: Prevalence of Nickel Sensitivity and Effects of a Low-Nickel Diet. An Open-Label Pilot Study

Irritable Bowel Syndrome-Like Disorders in Endometriosis: Prevalence of Nickel Sensitivity and Effects of a Low-Nickel Diet. An Open-Label Pilot Study

Nickel Allergy Is a Risk Factor for Endometriosis: An 11-Year Population-Based Nested Case-Control Study

Research in Benign Gynaecology

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