High Rate of Endometriosis Recurrence in Young Women

Tandoi, Iacopo; Somigliana, Edgardo; Riparini, Jennifer; Ronzoni, Stefania; Viganò, Paola; Candiani, Massimo

doi:10.1016/j.jpag.2011.06.012

Cited by 92 publications

(66 citation statements)

References 17 publications

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“…A second-look laparoscopy was performed in 34% of the patients for persistent pain. This observation of a high rate of recurrent symptoms in adolescents after surgical treatment of endometriosis has been reported in previous studies [2,3]. The authors state that they advised medical therapy after surgical therapy; how many patients actually received any therapy, and for how long, is unclear.…”

Section: See Related Article On Page 834supporting

confidence: 60%

Adolescent Endometriosis

Attaran¹,

Falcone²

2015

Journal of Minimally Invasive Gynecology

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Section: See Related Article On Page 834supporting

confidence: 60%

Adolescent Endometriosis

Attaran¹,

Falcone²

2015

Journal of Minimally Invasive Gynecology

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“…In addition, subfertility will be a concern in these patients with a history of endometriosis, particularly in the presence of recurrent symptoms or disease. Recurrence rates following surgery were high in the report by Tandoi et al [27]; there was 56% recurrence during a 5 year follow up amongst 57 young women aged 21 years. Only 34% of these recurrences were confirmed laparoscopically and in the remaining 66% the diagnosis of recurrence was based on symptoms or ultrasound findings.…”

Section: Diagnosis and Managementmentioning

confidence: 86%

Adolescent endometriosis

Sarıdoğan

2017

European Journal of Obstetrics & Gynecology and Reproductiv

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Endometriosis is a common finding in adolescents who have a history of chronic pelvic pain or dysmenorrhoea resistant to medical treatment, however the exact prevalence is unknown. Both early/superficial and advanced forms of endometriosis are found in adolescents, including ovarian endometriomas and deep endometriotic lesions. Whilst spontaneous resolution is possible, recent reports suggest that adolescent endometriosis can be a progressive condition, at least in a significant proportion of cases. It is also claimed that deep endometriosis has its roots in adolescence. Optimum treatment is far from clear and long term recurrence is still a significant problem. The most frequently reported treatment approach in the published literature is a combination of surgery and postoperative hormonal treatment with the combined oral contraceptives, progestins, levonorgestrel intrauterine system or gonadotrophin releasing hormone analogues. Use of gonadotrophin releasing hormone analogues and long term progestins should be carefully considered due to concerns over continuing bone formation in this age group. There is currently no consensus as to whether surgery should be avoided as much as possible to prevent multiple operations in the long term, or surgical treatment should be considered at an early stage before more severe lesions develop. Further research is required to determine which approach would offer a better long term outcome.

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“…This seems to be correlated not only to the higher density of pre-existing follicles in the ovary, but also to a more Binflammatory typology^of endometriosis at a younger age [28]. Young women also have a higher recurrence rate of their endometriomas (30-50 %) that often leads to repeated ovarian surgery which further compromises ovarian reserve [29]. Lastly, extensive adhesiolysis even without direct surgery to the ovaries has been associated with a significant decline in ovarian reserve.…”

Section: Reduced Ovarian Reserve In Patients Affected By Endometriosismentioning

confidence: 99%

The role of fertility preservation in patients with endometriosis

Carrillo

Seidman

Cittadini

et al. 2016

J Assist Reprod Genet

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Patients affected with severe endometriosis are at significant risk for ovarian tissue damage, which may lead to infertility, reduced response to ovarian stimulation, and occasionally, premature ovarian failure. The risk for a compromised ovarian reserve in young patients is especially high following repeated surgical intervention and in the presence of bilateral endometriomas. In many cases, enhanced loss of ovarian reserve may also result from the damaging effect of the pathologic process on follicle reservoir even without surgical interventions. Women diagnosed with severe endometriosis and those designated for extensive ovarian surgical intervention are frequently not planning to conceive. In light of recent advances in fertility preservation techniques (FPT), such as oocytes and ovarian tissue freezing, as well as their increasing success rates, we critically evaluate the options for FPT in patients suffering from endometriosis. Personalized counseling should be offered to all patients with endometriosis taking into account age, extent of ovarian involvement, current ovarian reserve, previous and impending surgeries for endometriosis, along with current success rates and possible risks associated with FPT.

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High Rate of Endometriosis Recurrence in Young Women

Cited by 92 publications

References 17 publications

Adolescent Endometriosis

Adolescent Endometriosis

Adolescent endometriosis

The role of fertility preservation in patients with endometriosis

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