High rate of colistin dependence in<i>Acinetobacter baumannii</i>

Hong, Yoon-Kyoung; Lee, Ji-Young; Wi, Yu Mi; Ko, Kwan Soo

doi:10.1093/jac/dkw121

Cited by 21 publications

(20 citation statements)

References 5 publications

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“…Recently, we reported the development of colistin dependence in clinical colistin-susceptible A. baumannii isolates after exposure to colistin [82]. In that study, development of colistin dependence was not rare; 32.9% of 149 colistin-susceptible isolates developed colistin dependence.…”

Section: ~10mentioning

confidence: 95%

“…Genotypic analyses revealed that colistin dependence originated from the corresponding susceptible parental isolates, and no evidence of clonal dissemination of the isolates that developed colistin dependence was found. Colistin-dependent mutants have shown increased susceptibility to several antibiotics, such as carbapenems [72,81,82], which is the feature of LPS-deficient, colistin-resistant isolates [51,52]. Of note, patients with colistin-dependent strains have shown higher 3-and 7-day treatment failure than the patients without colistin-dependent strains [82].…”

Section: ~10mentioning

confidence: 99%

“…Colistin-dependent mutants have shown increased susceptibility to several antibiotics, such as carbapenems [72,81,82], which is the feature of LPS-deficient, colistin-resistant isolates [51,52]. Of note, patients with colistin-dependent strains have shown higher 3-and 7-day treatment failure than the patients without colistin-dependent strains [82]. Thus, the development of colistin-dependent mutants may have clinical significance, and it should be investigated.…”

Section: ~10mentioning

confidence: 99%

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Old drug, new findings: colistin resistance and dependence of Acinetobacter baumannii

Choi

Lee

2017

Precis Future Med

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Colistin is an old drug, and its use has recently resurged because of increasing antibiotic resistance in gram-negative bacteria such as Acinetobacter baumannii. Although the colistin resistance rates in gram-negative bacteria are currently not high, many colistin-resistant isolates are being identified and the possibility of horizontal transmission of colistin resistance has increased because of the plasmid-borne colistin resistance gene mcr-1 (mobilized colistin resistance). In this review, we have discussed colistin resistance in A. baumannii. In addition, we have reviewed an abnormal phenomenon called colistin dependence in A. baumannii.

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Section: ~10mentioning

confidence: 95%

Section: ~10mentioning

confidence: 99%

Section: ~10mentioning

confidence: 99%

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Old drug, new findings: colistin resistance and dependence of Acinetobacter baumannii

Choi

Lee

2017

Precis Future Med

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“…Partial colistin dependence has been detected in several LPS-deficient strains with mutations in lpxA, lpxC , and lpxD (Garcia-Quintanilla et al, 2015). Many colistin-susceptible A. baumannii isolates develop colistin dependence in vitro after exposure to colistin (Hong et al, 2016). Although the clinical implication of colistin dependence and its molecular mechanism remain unclear, it is interesting that patients with colistin-dependent A. baumannii isolates show a high rate of treatment failure (Hong et al, 2016).…”

Section: Prospective Treatment Optionsmentioning

confidence: 99%

Biology of Acinetobacter baumannii: Pathogenesis, Antibiotic Resistance Mechanisms, and Prospective Treatment Options

Lee

Park

et al. 2017

Front. Cell. Infect. Microbiol.

717

585

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Acinetobacter baumannii is undoubtedly one of the most successful pathogens responsible for hospital-acquired nosocomial infections in the modern healthcare system. Due to the prevalence of infections and outbreaks caused by multi-drug resistant A. baumannii, few antibiotics are effective for treating infections caused by this pathogen. To overcome this problem, knowledge of the pathogenesis and antibiotic resistance mechanisms of A. baumannii is important. In this review, we summarize current studies on the virulence factors that contribute to A. baumannii pathogenesis, including porins, capsular polysaccharides, lipopolysaccharides, phospholipases, outer membrane vesicles, metal acquisition systems, and protein secretion systems. Mechanisms of antibiotic resistance of this organism, including acquirement of β-lactamases, up-regulation of multidrug efflux pumps, modification of aminoglycosides, permeability defects, and alteration of target sites, are also discussed. Lastly, novel prospective treatment options for infections caused by multi-drug resistant A. baumannii are summarized.

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“…Evidence shows that Acinetobacter isolates were previously susceptible to colistin, however, now they are characterized by resistance and, in some cases, dependence on this antimicrobial. Patients suffering from A. baumannii infections dependent to colistin are associated with a high rate of failure in treatment [176,177].…”

Section: Polymyxins (Colistin and Polymyxin B) And Therapeutic Combinmentioning

confidence: 99%

Acinetobacter baumannii Resistance: A Real Challenge for Clinicians

et al. 2020

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Acinetobacter baumannii (named in honor of the American bacteriologists Paul and Linda Baumann) is a Gram-negative, multidrug-resistant (MDR) pathogen that causes nosocomial infections, especially in intensive care units (ICUs) and immunocompromised patients with central venous catheters. A. baumannii has developed a broad spectrum of antimicrobial resistance, associated with a higher mortality rate among infected patients compared with other non-baumannii species. In terms of clinical impact, resistant strains are associated with increases in both in-hospital length of stay and mortality. A. baumannii can cause a variety of infections; most involve the respiratory tract, especially ventilator-associated pneumonia, but bacteremia and skin wound infections have also been reported, the latter of which has been prominently observed in the context of war-related trauma. Cases of meningitis associated with A. baumannii have been documented. The most common risk factor for the acquisition of MDR A baumannii is previous antibiotic use, following by mechanical ventilation, length of ICU/hospital stay, severity of illness, and use of medical devices. Current efforts focus on addressing all the antimicrobial resistance mechanisms described in A. baumannii, with the objective of identifying the most promising therapeutic scheme. Bacteriophage- and artilysin-based therapeutic approaches have been described as effective, but further research into their clinical use is required

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High rate of colistin dependence inAcinetobacter baumannii

Cited by 21 publications

References 5 publications

Old drug, new findings: colistin resistance and dependence of Acinetobacter baumannii

Old drug, new findings: colistin resistance and dependence of Acinetobacter baumannii

Biology of Acinetobacter baumannii: Pathogenesis, Antibiotic Resistance Mechanisms, and Prospective Treatment Options

Acinetobacter baumannii Resistance: A Real Challenge for Clinicians

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