High Proximal Excretion of Sodium during Activation of β&lt;sub&gt;2&lt;/sub&gt;-Adrenoreceptors in Humans

Duss, G.; Bianchetti, Mario G.; Cattaneo, Frederica; Mullis, Primus-E.; Kramer, R. E.; Peheim, E.; Oetliker, O

doi:10.1159/000187403

Cited by 2 publications

(1 citation statement)

References 15 publications

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“…The potential of selective ß 2 -agonists to produce hypocalcemia, hypomagnesemia, hypophosphatemia, and especially hypokalemia and hyperglycemia is well recognized but often overlooked in clinical practice [2,[67][68][69]. The present review of the literature points out that relevant hyperlactatemia is also common (about 20%) on high dose treatment with these agents.…”

Section: Discussionmentioning

confidence: 80%

Selective ß2-Adrenoceptor Agonists and Relevant Hyperlactatemia: Systematic Review and Meta-Analysis

Liedtke

Lava

Milani

et al. 2019

JCM

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Selective ß2-agonists have been imputed as potential cause of l-hyperlactatemia since the 1970s. To document the prevalence of hyperlactatemia associated with selective ß2-agonists and to investigate the predisposing factors, we searched for published articles until April 2019 pertaining to the interplay of administration of selective ß2-agonists and circulating l-lactic acid in the Excerpta Medica, Web of Science, and the U.S. National Library of Medicine databases. Out of the 1834 initially retrieved records, 56 articles were included: 42 papers reporting individual cases, 2 observational studies, and 12 clinical trials. Forty-seven individual patients receiving a selective ß2-agonist were found to have l-lactatemia ≥5.0 mmol/L, which decreased by ≥3.0 mmol/L or to ≤2.5 mmol/L after discontinuing (N = 24), reducing (N = 17) or without modifying the dosage of the selective ß2-agonist (N = 6). Clinical trials found that l-lactic acid significantly increased in healthy volunteers administered a ß2-agonist. l-lactatemia ≥5.0 mmol/L was observed in 103 (24%) out of 426 patients with asthma or preterm labor managed with a selective ß2-agonist and was more common in patients with asthma (30%) than in premature labor (5.9%). A significant relationship was also noted between l-lactate level and intravenous albuterol dose or its circulating level. In conclusion, relevant l-hyperlactatemia is common on high dose treatment with a selective ß2-agonist.

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Section: Discussionmentioning

confidence: 80%

Selective ß2-Adrenoceptor Agonists and Relevant Hyperlactatemia: Systematic Review and Meta-Analysis

Liedtke

Lava

Milani

et al. 2019

JCM

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Differential Regulation of Circulating Mg ²⁺ in the Rat by β ₁ - and β ₂ -Adrenergic Receptor Stimulation

Keenan

Romani

Scarpa

1995

Circulation Research

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Extracellular Mg2+ homeostasis was studied in vivo in the anesthetized rat. Animals were infused with isoproterenol (ISO) for 10 minutes, and serum Mg2+ was measured after the infusion and then 10 and 20 minutes later. A dose-dependent increase in circulating Mg2+ was observed in animals infused with ISO at a rate of 0.1 microgram.kg-1.min-1 or higher. The time course of the effect demonstrated that circulating Mg2+ continued to increase 20 minutes after the end of the ISO infusion. A predicted maximal increase in serum Mg2+ concentration of 19.3% was derived with a predicted EC50 of 0.08 microgram.kg-1.min-1. The maximal percent increase corresponded to a net increase of 6.7 mumol/300 g body wt. Because infusion of ISO resulted in changes in hemodynamic parameters, most notably a drop in blood pressure, a group of animals was infused with nitroprusside to mimic the hypotensive response via a nonadrenergic mechanism. Under these conditions, there was a transient increase in circulating Mg2+ that was largely inhibited by propranolol, indicating that hypotension per se was not responsible for the mobilization of Mg2+. Infusion of salbutamol, but not prenalterol, also induced an increase in circulating Mg2+. Pretreatment with butoxamine, ICI-118551, or propranolol prevented the ISO-induced increase in serum Mg2+. Pretreatment with atenolol minimally affected the ISO-induced changes in circulating Mg2+. Pretreatment with CGP-20271A actually enhanced the ISO-induced increase in circulating Mg2+. This evidence demonstrates the existence of a pool of Mg2+ that is mobilized into the circulation in response to selective beta 2-adrenergic stimulation.

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High Proximal Excretion of Sodium during Activation of β<sub>2</sub>-Adrenoreceptors in Humans

Cited by 2 publications

References 15 publications

Selective ß2-Adrenoceptor Agonists and Relevant Hyperlactatemia: Systematic Review and Meta-Analysis

Selective ß2-Adrenoceptor Agonists and Relevant Hyperlactatemia: Systematic Review and Meta-Analysis

Differential Regulation of Circulating Mg ²⁺ in the Rat by β ₁ - and β ₂ -Adrenergic Receptor Stimulation

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High Proximal Excretion of Sodium during Activation of β<sub>2</sub>-Adrenoreceptors in Humans

Cited by 2 publications

References 15 publications

Selective ß2-Adrenoceptor Agonists and Relevant Hyperlactatemia: Systematic Review and Meta-Analysis

Selective ß2-Adrenoceptor Agonists and Relevant Hyperlactatemia: Systematic Review and Meta-Analysis

Differential Regulation of Circulating Mg 2+ in the Rat by β 1 - and β 2 -Adrenergic Receptor Stimulation

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Differential Regulation of Circulating Mg ²⁺ in the Rat by β ₁ - and β ₂ -Adrenergic Receptor Stimulation