High Protein, Low Caloric Diet for the Prevention of Toxemia of Pregnancy

Luikart, Ralph

doi:10.1016/s0002-9378(15)30256-8

Cited by 13 publications

(1 citation statement)

References 5 publications

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“…How to prevent preeclampsia (PE) has been debated for more than 70 years. 1 A landmark publication was a report by Hamlin in The Lancet in 1952 entitled “Prevention of preeclampsia.” 2 Allegedly inspired by the astonishing low incidence of PE in Ethiopia, 3 Hamlin, who worked at The Women’s Hospital, Sydney, Australia, reported a marked reduction in the incidence and severity of PE, as well as eradication of eclampsia, following implementation of an Ethiopian-like diet (high-protein, high-vitamin, and low-carbohydrate) and strict weight control in pregnancy. 2 Despite the apparent success of this dietary intervention, the focus soon shifted toward drug prevention.…”

Section: Introductionmentioning

confidence: 99%

Adolescent Preeclampsia: Pathological Drivers and Clinical Prevention

et al. 2019

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Preeclampsia is an important cause of maternal and perinatal morbidity, especially in first-time pregnant adolescent women. Although prevention of preeclampsia has been attempted for many decades, effective intervention can only be achieved upon the full elucidation of the risk factors and mechanisms of disease. As the pathogenesis of preeclampsia during adolescence may differ from that in older women, preventive interventions should be tailored accordingly. During adolescence, 4 putative drivers of preeclampsia can be identified. First, uterine immaturity in very young teenagers is likely a major cause of defective deep placentation and adverse reproductive outcome, underscoring the importance of educational programs and public health initiatives focused on teen pregnancy prevention. Second, the association between adolescent obesity and preeclampsia merits further studies on the benefits of weight loss and dietary interventions to improve pregnancy outcome. Third, there is a need for greater awareness of the link between cardiovascular risk factors in young women and early-onset preeclampsia associated with atherosclerosis of the uteroplacental arteries. Finally, infrequent menstruations may prolong uterine immaturity because of lack of "menstrual preconditioning." This risk factor may be amenable to pharmacological/hormonal preconditioning prior to conception.

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