High progesterone levels adversely affect embryo quality and pregnancy rates in in vitro fertilization and oocyte donation programs

Yovel, Israel; Yaron, Yuval; Agarwal, Amit; Peyser, M. Reuben; David, Menachem P.; Kogosowski, Abraham; Lessing, Joseph B.

doi:10.1016/s0015-0282(16)57668-7

Cited by 49 publications

(28 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On the other hand, poorer embryo quality was not found in a number of studies [2,3,7,12,43,58,59]. These findings suggest that PL may influence the endometrium, adversely affecting implantation and subsequent embryo development due to PL.…”

Section: Impactmentioning

confidence: 83%

“…These findings suggest that PL may influence the endometrium, adversely affecting implantation and subsequent embryo development due to PL. This hypotheses was sustained by others groups [41,58,[60][61][62][63]. Forman et al [61], Sharma et al [58] and Silverberg et al [7] suggested that the mechanism of deleterious effect of elevated progesterone was abnormally accelerated endometrial maturation leading to impaired endometrial receptivity.…”

Section: Impactmentioning

confidence: 90%

“…This hypotheses was sustained by others groups [41,58,[60][61][62][63]. Forman et al [61], Sharma et al [58] and Silverberg et al [7] suggested that the mechanism of deleterious effect of elevated progesterone was abnormally accelerated endometrial maturation leading to impaired endometrial receptivity. Melo et al analysed retrospectively 240 oocyte-donation cycles in which 120 women donated twice, with PL in the first donation cycle and no PL in the following one, acting as its own control [64].…”

Section: Impactmentioning

confidence: 90%

See 2 more Smart Citations

Progesterone rise on the day of HCG administration (premature luteinization) in IVF: An overdue update

Elnashar

2010

J Assist Reprod Genet

View full text Add to dashboard Cite

Premature luteinization (PL) refers to a rise in serum progesterone (P) levels on the day of hCG administration. Most studies used an absolute P level on the day of hCG administration as an indicator of PL, and the cutoff level differed from 0.8 to 2 ng/mL. Some authors defined PL as a P/E2 ratio of >1. There is a marked variation in the incidence (13% to 71%), of PL due to discrepancies in definition, population characteristics and/or treatment protocols. The pathogenesis of PL in COH is still poorly understood. Several hypotheses may be considered to explain this phenomenon: elevation of follicular LH levels, serum accumulation of HCG from HMG, increased LH receptor sensitivity of the granulosa cells to FSH, or poor ovarian response with increased LH sensitivity. The consequences of this premature elevation of serum P on IVF outcome remain controversial. Attempts to prevent COH include: use of Low-dose hCG alone in the late COH stages, flexible antagonist protocol, use of mifepristone, aspiration of a single leading follicle, hCG administration when the levels of serum P exceeded 1.0 ng/mL.

show abstract

Section: Impactmentioning

confidence: 83%

Section: Impactmentioning

confidence: 90%

Section: Impactmentioning

confidence: 90%

See 1 more Smart Citation

Progesterone rise on the day of HCG administration (premature luteinization) in IVF: An overdue update

Elnashar

2010

J Assist Reprod Genet

View full text Add to dashboard Cite

show abstract

“…Two mechanisms have been proposed: either a poor oocyte quality plus a reduction in their fertilizability (3,4), or a detrimental effect on endometrial receptivity (2,5).…”

mentioning

confidence: 99%

Progesterone rise on the day of human chorionic gonadotropin administration impairs pregnancy outcome in day 3 single-embryo transfer, while has no effect on day 5 single blastocyst transfer

Papanikolaou

Kolibianakis

Pozzobon

et al. 2009

Fertility and Sterility

143

137

View full text Add to dashboard Cite

“…The pathogenesis and etiology of PL are still debatable (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12). The pathogenesis of PL in nonGnRH-a cycles is believed to be the result of increased preovulatory levels of LH.…”

mentioning

confidence: 99%

An increased serum progesterone-to-estradiol ratio on the day of human chorionic gonadotropin administration does not have a negative impact on clinical pregnancy rate in women with normal ovarian reserve treated with a long gonadotropin releasing hormone agonist protocol

Lai

Lee

Lin

et al. 2009

Fertility and Sterility

View full text Add to dashboard Cite

High progesterone levels adversely affect embryo quality and pregnancy rates in in vitro fertilization and oocyte donation programs

Cited by 49 publications

References 6 publications

Progesterone rise on the day of HCG administration (premature luteinization) in IVF: An overdue update

Progesterone rise on the day of HCG administration (premature luteinization) in IVF: An overdue update

Progesterone rise on the day of human chorionic gonadotropin administration impairs pregnancy outcome in day 3 single-embryo transfer, while has no effect on day 5 single blastocyst transfer

An increased serum progesterone-to-estradiol ratio on the day of human chorionic gonadotropin administration does not have a negative impact on clinical pregnancy rate in women with normal ovarian reserve treated with a long gonadotropin releasing hormone agonist protocol

Contact Info

Product

Resources

About