High Prevalence of Vitamin D Deficiency in 1048 Romanian Women with Postmenopausal Osteoporosis

Grigorie, Daniel

doi:10.4183/aeb.2008.33

Cited by 13 publications

(13 citation statements)

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“…Another cross-sectional cohort study in the US communicated low calcidiol levels (<30ng/mL) in 71% and 83% of CKD stage 3 and 4 patients, respectively, regardless of geographic location (23). Similarly high proportions of vitamin D deficit were reported in non-CKD populations, as low levels of calcidiol (<30ng/mL) were observed in 87% of young healthy women in a sunny country like Saudi Arabia (24), more than 90% of young (35±8 years old) healthy care-givers in Romania (25), and around 83% in Romanian postmenopausal women (12). Another study from Romania found an overall reduced vitamin D in 59% of a large cohort of wide age and geographical distribution range, especially in the elderly (four out of five octogenarians), women and wintertime (26).…”

Section: Discussionmentioning

confidence: 84%

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The Prevalence of Biochemical Abnormalities of Chronic Kidney Disease. Mineral and Bone Disorders in Untreated Non-dialysis Patients – A Multicenter Study

Căpuşă

Chirculescu

Vladu³

et al. 2016

Acta Endo (Buc)

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Section: Discussionmentioning

confidence: 84%

“…The high prevalent vitamin D deficiency probably has a causal role. Indeed, hyperparathyroidism (defined as serum iPTH above the upper limit recommended by the manufacturer) was reported in almost 20% of a Romanian cohort of postmenopausal women and its prevalence varied inversely with the calcidiol levels (12).…”

Section: Discussionmentioning

confidence: 99%

The Prevalence of Biochemical Abnormalities of Chronic Kidney Disease. Mineral and Bone Disorders in Untreated Non-dialysis Patients – A Multicenter Study

Căpuşă

Chirculescu

Vladu³

et al. 2016

Acta Endo (Buc)

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“…Vitamin D insufficiency and deficiency have become a global health problem during the past decade (1,2). Traditionally they were linked to low bone density, osteoporosis and fracture risk (3,4). However, the relationship between the vitamin D status and different features of the metabolic syndrome and the related cardiovascular risk has come increasingly into focus.…”

Section: Introductionmentioning

confidence: 99%

Correlations of Serum Vitamin D with Metabolic Parameters in Adult Outpatients with Different Degrees of Overweight / Obesity Coming from an Urban Community

Nikolova

Boyanov²,

Tsakova

2018

Acta Endo (Buc)

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Objective. To describe the correlations between serum 25(OH) vitamin D and anthropometric and metabolic parameters in adult outpatients of both sexes with different BMI coming from an urban community. Subjects and Methods. 264 subjects referred for obesity assessment participated-109 men and 155 women (20-60 years). Body weight and height, waist circumference (WC), blood pressure were recorded. Body composition was assessed by bioelectrical impedance (BIA) on a Tanita BC 420 MA analyzer (Tanita Inc., Japan). Serum 25(OH)D Total, Insulin, High-sensitivity C-reactive protein, blood glucose, total, HDL-cholesterol and triglycerides were measured. The insulin resistance index was calculated (HOMA-IR). Participants with BMI>25.0 kg/m 2 underwent standard 75 g OGTT. Statistical analysis was performed on an IBM SPSS Statistics 19.0 for Windows platform (Chicago, IL). Results. Normal weight was found in 27.2 % of the participants, 24.6 % had overweight, 29.2 %-class I obesity, and 18.9 %-class II or III. Vitamin D was weakly and inversely correlated to different variables in the whole group-such as weight, WC, WC/Height, % body fat and HOMA-IR index (r=-0.231,-0.283,-0.307,-0.339,-0.328 respectively, all p<0.001). Building subgroups based on BMI led to loss of significance. Backward analysis revealed Total-C/LDL-C ratio, and LDL-C/HDL-C ratio as strongest predictors of serum vitamin D (p=0.001; R2=0.204). Conclusion. The association of vitamin D with blood pressure, plasma lipids, glucose and insulin is very weak on an individual level. However, several obesity indices (WC, WC/height ratio, % Body fat from BIA) might be used as a screening tool for subjects at risk for vitamin D deficiency.

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“…Patients with PHPT have been shown to have lower 25-hydroxyvitamin D (25OHD) levels than the general population (18). In our country there is a high prevalence of vitamin D deficiency (19) and even higher in patients with PHPT (Grigorie D, personal communication). In the Chow et al study (8), in the alendronate group, serum calcium concentration showed a mild (0.36 mg/dL), but significant decrease from a mean of 11.28 mg/dL to 10.96 mg/dL at the end of 48 wk.…”

Section: Discussionmentioning

confidence: 95%

A Single-Dose, Open-Label, Prospective Clinical Study of Denosumab in Patients with Primary Hyperparathyroidism

Grigorie¹

2014

Acta Endo (Buc)

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Background. The purpose of this study was to observe the effects of denosumab on bone mineral density (BMD), bone turnover markers and serum calcium in patients with primary hyperparathyroidism (PHPT) and osteoporosis.Methods. Seven consecutive patients with PHPT were administered a single subcutaneous injection of denosumab, 60 mg. The subjects were followed up to 6 months: serum calcium on days 1,3,7,14,30 and at 3 months and 6 months; serum intact parathyroid hormone (iPTH), C-telopeptide (CTX) and N-mid osteocalcin at baseline, 3 months and 6 months. BMD by DXA, at the femoral neck (FN) and lumbar spine (LS), were measured at baseline and at 6 months.Results. The patients (mean age= 69.8 yrs, range 62-81) had mild PHPT (mean total calcium = 10.8 mg/dL; mean PTH = 148.9 pg/mL); all had osteoporosis and four were currently treated with various bisphosphonates (BP). After 6 months mean LS BMD increased significantly by 4.5 % (p = 0.04) and mean FN BMD by 2.4% (p= 0.09 two-tailed; p = 0.047 one-tailed). Serum CTX decreased significantly by 90% at 3 months (p = 0.04), and by 48% at 6 months (p = 0.02); the similar changes for serum osteocalcin were 41% and 42% (p = 0.07, one-tailed), respectively. In the first two weeks, serum total Ca variably decreased vs. baseline (0.5 to 2.8 mg/dL) in six out of seven patients. After 6 months mean total serum Ca nonsignificantly increased vs. baseline (11.4 mg/dL vs. 10.8 mg/dL, p = 0.1). Serum iPTH levels did not significantly change at both 3 and 6 months; after 6 months there was a trend toward decreased values (p = 0.03 onetailed).Conclusion. Denosumab increased BMD at both lumbar spine and femoral neck, and significantly decreased bone resorption in patients with PHPT. The effects on hypercalcemia were mild and transient, with a numerical increase after 6 months.

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High Prevalence of Vitamin D Deficiency in 1048 Romanian Women with Postmenopausal Osteoporosis

Cited by 13 publications

References 0 publications

The Prevalence of Biochemical Abnormalities of Chronic Kidney Disease. Mineral and Bone Disorders in Untreated Non-dialysis Patients – A Multicenter Study

The Prevalence of Biochemical Abnormalities of Chronic Kidney Disease. Mineral and Bone Disorders in Untreated Non-dialysis Patients – A Multicenter Study

Correlations of Serum Vitamin D with Metabolic Parameters in Adult Outpatients with Different Degrees of Overweight / Obesity Coming from an Urban Community

A Single-Dose, Open-Label, Prospective Clinical Study of Denosumab in Patients with Primary Hyperparathyroidism

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