High Prevalence of Vitamin D Deficiency among Patients with Inflammatory Bowel Disease

Abstract

Background: Vitamin D is a hormone with immunomodulatory properties. Vitamin D deficiency has been reported for patients with inflammatory bowel disease (IBD). In this cross-sectional study, 25-hydroxyvitamin D3 (25-OH-D3) levels in patients with IBD were compared to those in patients with irritable bowel syndrome (IBS). Methods: A total of 181 patients, 156 with IBD and 25 with IBS, were included. The influence of disease activity, inflammatory markers, physical activity, and season were assessed. Results: A total of 58.6% (n = 58) of the patients with Crohn’s disease (CD) and 44.6% (n = 25) of the patients with ulcerative colitis (UC) had a 25-OH-D3 level < 50 nmol/L. CD patients showed significantly decreased 25-OH-D3 levels compared to the IBS patients (p = 0.018), but no significant difference was found for UC patients. In a linear regression model adjusted for age, gender, and BMI, a significant inverse association of C-reactive protein (CRP) (p = 0.031) and faecal calprotectin (FC) (p = 0.025) with 25-OH-D3 levels was observed for CD patients. Seasonal variation in 25-OH-D3 levels was found in CD patients, with significantly lower values in spring than in summer (p = 0.04). Conclusion: Vitamin D deficiency was common in all IBD patients, but more pronounced in CD patients, in whom it also showed a significant inverse association with inflammatory markers such as CRP and FC.

Serum Biomarkers for Inflammatory Bowel Disease

“…Vitamin D (25-hydroxyvitamin D; [25(OH)D]) is an immune modulator of the innate and adaptive immune systems, and deficiency in IBD patients is associated with an increased risk of disease recurrence, hospitalizations, and surgeries (67). CD patients show high prevalence of vitamin D deficiency and have significantly lower vitamin D levels than do patients with irritable bowel syndrome (169). Serum vitamin D level is negatively correlated with disease activity in CD patients (170).…”

Ernährung bei entzündlichen Darmerkrankungen

“…Bis zu 60% der IBD-Patienten, insbesondere Patienten mit der Diagnose MC und erhöhter Krankheitsaktivität [72, 193, 194] sowie Schwangere mit IBD, leiden an Vitamin-D-Mangel [195]. Interessanterweise besitzen junge männliche Patienten ein sehr hohes Risiko [141], und MC-Patienten mit isolierter Kolonbeteiligung bzw.…”

Screening and Treatment of Vitamin D Deficiency in UK Patients with Crohn’s Disease: Self-Reported Practice among Gastroenterologists

“…It is recognised that patients with inflammatory bowel diseases (IBD) are at high risk of developing vitamin D deficiency [1], with the highest prevalence often reported in those with Crohn's disease (CD) [2][3][4][5]. Though it remains unclear if this is a cause or a consequence of the disease, there is growing interest in the non-skeletal benefits of treating vitamin D deficiency in this group, as previously described by the authors [1].…”