High prevalence of vitamin D deficiency in Shenzhen pregnant women

Zhao, Lijun; Chen, Rui; Nong, Baoting; Yu, Dou; Li, Yuxia; Xu, Zhi‐Kang; Ma, Caifeng; Du, Jikun; Liu, Helu

doi:10.1080/14767058.2021.1910667

Cited by 4 publications

(4 citation statements)

References 35 publications

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“…A study from Shenzhen, China, showed that season was also an associated factor for vitamin D deficiency in pregnant women. (Winter vs autumn vs spring, OR = 3.69, P < 0.001) 41 . Other studies report the association between BMI 42 , gestational frequency 43,44 and gestational age 39,45-47 and maternal vitamin D The current study's novelty is that the relationship between average temperature in the previous month and 25(OH)D levels varies across the seasons.…”

Section: Discussionmentioning

confidence: 98%

Correlation between meteorological factors and vitamin D status under different season

Wang

Lü

Shen

et al. 2023

Sci Rep

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Pregnant women with low vitamin D levels tend to have poor clinical outcomes. Meteorological factors were associated with vitamin D. Here, we aimed to study the current status of 25-Hydroxy vitamin D (25(OH)D) concentrations in pregnant women in Kunshan city and investigate the meteorological factors associated with 25(OH)D levels under different seasons. The correlation between meteorological factors and 25(OH)D levels was estimated by cross-correlation analysis and multivariate logistic regression. A restrictive cubic spline method was used to estimate the non-linear relationship. From 2015 to 2020, a total of 22,090 pregnant women were enrolled in this study. Pregnant women with 25(OH)D concentrations below 50 nmol/l represent 65.85% of the total study population. There is a positive correlation between temperature and 25(OH)D. And there is a protective effect of the higher temperature on vitamin D deficiency. However, in the subgroup analysis, we found that in autumn, high temperatures above 30 °C may lead to a decrease in 25(OH)D levels. This study shows that vitamin D deficiency in pregnant women may widespread in eastern China. There is a potential inverted U-shaped relationship between temperature and 25(OH)D levels, which has implications for understanding of vitamin D changes under different seasons.

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Section: Discussionmentioning

confidence: 98%

Correlation between meteorological factors and vitamin D status under different season

Wang

Lü

Shen

et al. 2023

Sci Rep

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“…Choi et al reported that the overall incidence of vitamin D deficiency and severe vitamin D deficiency in pregnant women was 77.3% and 28.6% respectively, with a higher prevalence observed in the first trimester among Korean women [ 11 ]. Similarly, Zhao et al conducted a study involving 27,166 healthy pregnant women in China and found a pooled prevalence of vitamin D deficiency of 34.3%, with incidence rates of 37.83%, 33.8%, and 29.3% for the first, second, and third trimesters respectively [ 12 ]. Our study found that following daily supplementation of 800IU vitamin D, 59.12% of the women reached vitamin D insufficiency status.…”

Section: Discussionmentioning

confidence: 99%

Vitamin D supplementation during pregnancy and the role of maternal prenatal depression

lv,

Zheng,

Han

2024

BMC Pregnancy Childbirth

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Background The current study sought to investigate the correlation between vitamin D supplementation in pregnant women with vitamin D deficiency in early pregnancy and the incidence of prenatal depression prior to delivery. Methods This is a retrospective, single-center study that was conducted at a tertiary hospital in Chengdu, China. We conducted an analysis on pregnant women who were initially diagnosed with vitamin D deficiency at 12–14 weeks of gestation. After starting vitamin D supplementation at a dose of 800 IU daily from 14 weeks onwards, we measured both their vitamin D concentration and depression scores again during median gestational week 39 prior to delivery. Results The study cohort comprised 1365 women who had been diagnosed with vitamin D deficiency at 12–14 weeks of gestation between November 1st, 2021 to November 1st, 2022. 537 pairs were matched based on a propensity score to control for other confounding factors. After propensity score matching, the baseline vitamin D levels were made consistent between the groups (P = 0.512). The incidence of depression in patients in vitamin D deficiency group following vitamin D supplementation was significantly higher than insufficiency group and reached statistical significance (P < 0.001). Additionally, we observed that serum 25-(OH) D concentration achieving insufficiency status after supplementation was 59.12%. Conclusion Our study indicates that daily supplementation of 800IU of vitamin D can improve the depressive symptoms of individuals who are vitamin D deficiency during early pregnancy but achieve vitamin D insufficiency after supplementation during prenatal period.

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“…Vitamin D status in fetus and newborns predominantly depends on maternal vitamin D status during pregnancy [17][18][19][20] . Several studies have revealed a high prevalence of vitamin D de ciency among Chinese pregnant women [21][22][23][24] . Maternal vitamin D de ciency is shown to be a risk factor for multiple perinatal complications including gestational diabetes mellitus (GDM) [25][26][27] and preeclampsia [28][29][30] , which are main reasons for elective preterm delivery.…”

Section: Introductionmentioning

confidence: 99%

Vitamin D-Related risk factors for preterm and full-term infants at birth: A retrospective study in Wuxi, China

Xiao,

Wu,

Zou

et al. 2024

Preprint

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Background/Objectives: Vitamin D is thought to play a role in early immune development of infants. However, national data on vitamin D status in newborns is limited in China. We aimed to evaluate the vitamin D status in preterm and full-term neonates and its influencing factors in Wuxi, southeastern China. Subjects/Methods: 813 infants born were recruited in this study from May 2020 to May 2022, including 167 very preterm (< 32+ 0 weeks), 454 preterm (32+ 0-36+ 6 weeks) and 192 full-term (≥ 37+ 0 weeks) newborns. The umbilical cord serum level of 25-hydroxyvitamin D (25(OH)D) was measured. Results The median level of serum 25(OH)D was 35.9 nmol/L, and 82.7% of them were vitamin D deficient. The serum 25(OH)D level was lower in full-term infants compared with preterm and very preterm infants at birth, while there was no significant difference (preterm, 95% confidence interval [CI], 0.484, 1.657, p = 0.725; very preterm, 95% CI, 0.434, 2.061, p = 0.946) in the prevalence of vitamin D deficiency among them. It was found that vitamin D deficiency in newborns was significantly associated with season of birth (Spring, 95% CI, 0.128,0.541, p < 0.001; Summer, 95% CI, 0.101, 0.491, p < 0.001; Autumn, 95% CI, 0.106, 0.465, p < 0.001) and maternal pre-pregnancy BMI (< 25 kg/m2, 95% CI, 0.150, 0.514, p < 0.001; 25–30 kg/m2, 95% CI, 0.277, 0.916, p = 0.025) after controlling for maternal age, birth weight and gestational age. Conclusions: More attentions should be focused on the nutritional vitamin D status of infants born in winter. Infants born to women who are obese before pregnancy are likely to have greater odds of vitamin D deficiency at birth which requires urgent attentions. Adequate daily vitamin D supplementation for newborns is recommended and warranted immediately after birth.

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High prevalence of vitamin D deficiency in Shenzhen pregnant women

Cited by 4 publications

References 35 publications

Correlation between meteorological factors and vitamin D status under different season

Correlation between meteorological factors and vitamin D status under different season

Vitamin D supplementation during pregnancy and the role of maternal prenatal depression

Vitamin D-Related risk factors for preterm and full-term infants at birth: A retrospective study in Wuxi, China

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