High Prevalence of Vitamin D Insufficiency in China: Relationship with the Levels of Parathyroid Hormone and Markers of Bone Turnover

Lu, Hankui; Zeng, Zhen; Ke, Yingying; He, Jia; Fu, Wen‐Zhen; Zhang, Changqing; Zhang, Zhenlin

doi:10.1371/journal.pone.0047264

Cited by 79 publications

(75 citation statements)

References 42 publications

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“…In a study from USA, the African-Americans were found to have significantly high prevalence of VDD 9 . In china too, during the winter season, the prevalence of vitamin D insufficiency (<30 ng/mL) was 84% in males and 89% in females 10 . However, in India, studies conducted even in summer showed significant VDD.…”

Section: Discussionmentioning

confidence: 95%

Blood vitamin D levels in a sample population from Eastern India: a pilot study

Paul

Ray

Saha

et al. 2014

Int Jour of Biomed Res

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Section: Discussionmentioning

confidence: 95%

Blood vitamin D levels in a sample population from Eastern India: a pilot study

Paul

Ray

Saha

et al. 2014

Int Jour of Biomed Res

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“…Given that absence of seasonal variation of 25(OH) D levels in our cohort, our findings seem to emphasize the influence of confounding variables, such as weight status, calcium intake and calcium absorption on elevation in PTH levels [17] [27] [36] [43].…”

Section: Discussionmentioning

confidence: 90%

Is There Any Threshold for Vitamin D That Elevates Parathyroid Hormone

Mert¹,

Tamer²,

Günay³

et al. 2017

OJEMD

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Objective: To evaluate vitamin D status in relation to serum levels for parathyroid hormone (PTH) and corrected calcium among endocrine outpatients. Methods: A total of 760 patients (mean(SD) age: 40.0(12.6) years, 94.6% were females) admitted to our endocrinology outpatient clinic were included and evaluated with respect to patient demographics, serum levels for 25-hydroxyvitamin D (25(OH) D, ng/mL), PTH (pg/mL) and corrected calcium (mg/dL) as well as the vitamin D status. Results: Vitamin D deficiency was determined in 65.0% and elevated PTH levels in 20.3% of patients. iPTH levels were significantly higher in females than in males (58.9(40.4) vs. 45.1(26.2) pg/mL, p = 0.031) and in summer than in winter cases (63.9(47.7) vs. 54.2(32.8) pg/mL, p = 0.002), whereas no difference was found in serum levels for 25(OH) D, corrected calcium and phosphate with respect to gender and season. Significantly higher levels for iPTH were noted in vitamin D deficient patients (60.7(43.9) pg/mL) than in normal (51.1(33.4) pg/mL) and vitamin D insufficient (57.1(26.0) pg/mL) cases (p = 0.03). iPTH levels were correlated positively with age (r = 0.116, p = 0.001) and negatively with corrected calcium (r = −0.097, p = 0.008), P (r = −0.224, p = 0.000) and 25(OH) D (r = −0.134, p = 0.000), whereas no correlation was noted between 25(OH) D and corrected calcium levels. Conclusion: Our findings indicated that vitamin D deficiency in 65.0%, whereas PTH elevation only in 20.3% of endocrine outpatients, despite the significantly negative correlation of PTH to 25(OH) D and significantly higher levels of PTH among vitamin D deficient cases than in vitamin D insufficient and sufficient cases. Gender's and seasonal differences had influence on serum levels for PTH but not on either 25(OH) D or corrected calcium, and no correlation was evident between 25(OH) D and corrected calcium levels.

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“…In this regard, two points must be taken into consideration. Firstly, in all these, and many other studies, the cutoff used for serum 25(OH)D to define vitamin D inadequacy is 75 nmol/L (16)(17)19) or even higher (18). In the current study, we categorized calcidiol concentrations less than 50 nmol/L as poor vitamin D status, according to the Institute of Medicine (IOM) (20).…”

Section: Discussionmentioning

confidence: 97%

Hypovitaminosis D in Adults Living in a Sunny City: Relation to Some Cardiometabolic Risk Factors, National Food and Nutrition Surveillance

Nikooyeh

Hajifaraji

Yarparvar³

et al. 2018

Nutr Food Sci Res

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A B S T R A C T Background and Objectives:Reports indicate that hypovitaminosis D is extremely common worldwide and is reemerging as a major health problem globally. In the present study, the main objectives were: 1) to examine whether healthy men and women living in Ahvaz have adequate vitamin D status; 2) to assess association between vitamin D status and some cardiometabolic risk factors. Materials and Methods: Conclusions:We found high prevalence of hypovitaminosis D in apparently healthy adults in Ahvaz, a sunny city of Iran. Our findings suggest that high vitamin D concentrations among the adult population are associated with a substantial decrease in body mass index. However, there was no association with the lipid profile components.

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High Prevalence of Vitamin D Insufficiency in China: Relationship with the Levels of Parathyroid Hormone and Markers of Bone Turnover

Cited by 79 publications

References 42 publications

Blood vitamin D levels in a sample population from Eastern India: a pilot study

Blood vitamin D levels in a sample population from Eastern India: a pilot study

Is There Any Threshold for Vitamin D That Elevates Parathyroid Hormone

Hypovitaminosis D in Adults Living in a Sunny City: Relation to Some Cardiometabolic Risk Factors, National Food and Nutrition Surveillance

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