High Prevalence of TT Virus Viremia in Italian Patients, Regardless of Age, Clinical Diagnosis, and Previous Interferon Treatment

Maggi, Fabrizio; Fornai, Claudia; Morrica, Antonietta; Casula, F.; Vatteroni, Maria Linda; Marchi, Santino; Ciccorossi, P.; Riente, Lucrezia; Pistello, Mauro; Bendinelli, Mauro

doi:10.1086/314961

Cited by 52 publications

(46 citation statements)

References 14 publications

(30 reference statements)

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“…At day 90, the mean TTV load was slightly increased relative to that at day 30, although the increase did not reach statistical significance. Table 1 also shows that in the same patients, baseline levels and responses to treatment of HCV were in line with published data (3,12,19). A substantial decline in mean HCV viremia was clearly evident at day 1 of treatment, when one patient was already below the assay sensitivity limit (3 log 10 copies/ml).…”

Section: Resultssupporting

confidence: 87%

Dynamics of Persistent TT Virus Infection, as Determined in Patients Treated with Alpha Interferon for Concomitant Hepatitis C Virus Infection

Maggi¹,

Pistello²,

Vatteroni³

et al. 2001

J Virol

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TT virus (TTV) is a recently identified widespread DNA virus of humans that produces persistent viremia in the absence of overt clinical manifestations. In an attempt to shed light on the dynamics of chronic infection, we measured the levels of TTV in the plasma of 25 persistently infected patients during the first 3 months of alpha interferon (IFN-␣) treatment for concomitant hepatitis C virus (HCV) infection. The first significant decline of TTV loads was observed at day 3 versus day 1 for HCV. Subsequently, the loads of TTV became progressively lower in most patients, but some initial responders relapsed before the end of the follow-up, suggesting that at least in some subjects the effects of IFN on TTV can be very short-lived. No correlation between the responses of TTV and HCV to therapy was found. Fitting the viremia data obtained during the first week of treatment into previously developed mathematical models showed that TTV sustains very active chronic infections, with over 90% of the virions in plasma cleared and replenished daily and a minimum of approximately 3.8 ؋ 10 10 virions generated per day. Low levels of TTV were occasionally detected in the peripheral blood mononuclear cells of patients who had cleared plasma viremia, thus corroborating previous results showing that these cells may support TTV replication and/or persistence.

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Section: Resultssupporting

confidence: 87%

Dynamics of Persistent TT Virus Infection, as Determined in Patients Treated with Alpha Interferon for Concomitant Hepatitis C Virus Infection

Maggi¹,

Pistello²,

Vatteroni³

et al. 2001

J Virol

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“…At the same time, epidemiological associations of TTV with B-cell lymphoma, Hodgkin's disease, aplastic anemia, idiopathic pulmonary fibrosis, acute respiratory disease, and autoimmune rheumatic disorders have also been described (6,16,29,30,32,52). Although TTV is potentially related to many diseases, its actual function is still questioned.…”

mentioning

confidence: 99%

Torque Teno Virus (SANBAN Isolate) ORF2 Protein Suppresses NF-κB Pathways via Interaction with IκB Kinases

Zheng

Fang

et al. 2007

J Virol

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“…Viremic hemophiliacs had increased levels of IgG and IgM in serum relative to TTV-negative hemophiliacs (187). Maggi et al (90) found that infection rates in patients with psoriasis, rheumatoid arthritis, or systemic lupus erythematosus were not higher than in patients with miscellaneous diseases. In another study, viremic patients with rheumatoid arthritis had a greatly enhanced frequency of rheumatoid factor positivity (54).…”

Section: Clinical Significancementioning

confidence: 99%

Molecular Properties, Biology, and Clinical Implications of TT Virus, a Recently Identified Widespread Infectious Agent of Humans

et al. 2001

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TT virus (TTV) was first described in 1997 by representational difference analysis of sera from non-A to non-G posttransfusion hepatitis patients and hence intensively investigated as a possible addition to the list of hepatitis-inducing viruses. The TTV genome is a covalently closed single-stranded DNA of approximately 3.8 kb with a number of characteristics typical of animal circoviruses, especially the chicken anemia virus. TTV is genetically highly heterogeneous, which has led investigators to group isolates into numerous genotypes and subtypes and has limited the sensitivity of many PCR assays used for virus detection. The most remarkable feature of TTV is the extraordinarily high prevalence of chronic viremia in apparently healthy people, up to nearly 100% in some countries. The original hypothesis that it might be an important cause of cryptogenic hepatitis has not been borne out, although the possibility that it may produce liver damage under specific circumstances has not been excluded. The virus has not yet been etiologically linked to any other human disease. Thus, TTV should be considered an orphan virus

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High Prevalence of TT Virus Viremia in Italian Patients, Regardless of Age, Clinical Diagnosis, and Previous Interferon Treatment

Cited by 52 publications

References 14 publications

Dynamics of Persistent TT Virus Infection, as Determined in Patients Treated with Alpha Interferon for Concomitant Hepatitis C Virus Infection

Dynamics of Persistent TT Virus Infection, as Determined in Patients Treated with Alpha Interferon for Concomitant Hepatitis C Virus Infection

Torque Teno Virus (SANBAN Isolate) ORF2 Protein Suppresses NF-κB Pathways via Interaction with IκB Kinases

Molecular Properties, Biology, and Clinical Implications of TT Virus, a Recently Identified Widespread Infectious Agent of Humans

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