High prevalence of truncus arteriosus in pediatric congenital heart disease in Uganda

Namuyonga, Judith; Lubega, Sulaiman; Aliku, Twalib; Omagino, John; Sable, Craig; Lwabi, Peter

doi:10.4103/apc.apc_161_18

Cited by 2 publications

(2 citation statements)

References 5 publications

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“…In part, this is due to a predominance of hospital studies with heterogenous methodology (Tankeu et al, 2017). Reviews from Uganda (Aliku et al, 2017;Namuyonga et al, 2019) found that the distribution of CHD was similar to other parts of the world with two notable exceptions. There was an exceedingly high incidence of truncus arteriosus (5% of CHDs) and very low incidence of coarctation (less than 0.5%).…”

Section: Case Studies-africamentioning

confidence: 99%

Congenital heart disease in low‐and‐middle‐income countries: Focus on sub‐Saharan Africa

Zimmerman

Sable

2020

American J of Med Genetics Pt C

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The etiology of congenital heart disease (CHD) is multifactorial. The birth prevalence of CHD is shaped by a wide variety of maternal, fetal, and neonatal risk factors, along with the rates of prenatal diagnosis and terminations of pregnancy, all of which have geographic variability Epidemiology data availability from low‐and‐middle‐income countries (LMIC) on CHD prevalence, morbidity, and mortality are far more limited than from high income countries. Data on specific genetic, environmental, and prenatal risk associated with CHD are almost nonexistent. In this article, we will focus on defining what data are available, genetic risk factors, birth and overall prevalence, morbidity, and the impact of limited access to interventions, both surgery and cardiac catheterizations. We will highlight CHD in sub‐Saharan Africa to detail epidemiology studies in the poorest regions of the world. Existing literature as well as estimates from the Global Burden of Disease Study (http://ghdx.healthdata.org) form the basis for this review. The intersection of poverty, high fertility rates, and limited access to care results in a unique profile of CHD in LMIC. CHD is not a preventable disease (by most standards), so early detection and access are our key interventions to improve the dire outcomes for children in low‐resources settings of the world.

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Section: Case Studies-africamentioning

confidence: 99%

Congenital heart disease in low‐and‐middle‐income countries: Focus on sub‐Saharan Africa

Zimmerman

Sable

2020

American J of Med Genetics Pt C

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“…Despite of the enormous epidemiological evidence on risk factors for CHD among children, no single study known to us examined the risk factors for CHD among children in Uganda. Recently published epidemiological studies in Uganda focused on description of the burden of CHD among children and adults, and the narrative of history of establishment CHD surgical treatment interventions [17][18][19]. Understanding the epidemiological risk profile for CHD among children in Uganda, is essential for developing prevention interventions that will contribute towards the realization of the vision of Uganda Heart Association [19], and the achievement of the sustainable development goal number 3.2 of reducing under-5 mortality to 25 deaths per 1,000 live births by the year 2030 [20].…”

Section: Introductionmentioning

confidence: 99%

Factors Associated with Congenital Heart Diseases among Children in Uganda: A Case-Control Study at Mulago National Referral Hospital (Uganda Heart Institute)

Kapakasi¹,

Mawa²,

Namuyonga³

et al. 2021

CCR

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Congenital Heart Diseases (CHD) are among the leading causes of morbidity and mortality associated with congenital malformations among children. Not knowing the risk profile of CHD among children in Uganda impedes development of effective prevention interventions. In this hospital based unmatched case-control study we examined risk factors for all types of CHD among 179 pair of case and control children aged 0-10 years old at Mulago National Referral Hospital. Odds ratios and their corresponding 95% confidence intervals were calculated using multivariate logistic regression. Low birth weight (adjusted OR: 3.15, 95% CI 1.48 -6.69), high birth order ≥5 th birth order (adjusted OR: 3.69 (1.10 -12.54), maternal febrile illness during pregnancy, maternal and paternal alcohol consumption, and paternal socio-economic status were associated with CHD. Family history of CHD, maternal education level, maternal chronic illness, and paternal education level were not associated with CHD. The results suggest: low birth weight, high birth order, and maternal febrile illness during pregnancy, parental alcohol use and paternal socio-economic status as dominant risk factors for CHD among children. Rigorous implementation of public health policies and strategies targeting prevention of febrile illness during pregnancy, maternal malnutrition, parental alcohol consumption, delivery of high number of children per woman, might be important in reducing the burden of CHD among children in Uganda.

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High prevalence of truncus arteriosus in pediatric congenital heart disease in Uganda

Cited by 2 publications

References 5 publications

Congenital heart disease in low‐and‐middle‐income countries: Focus on sub‐Saharan Africa

Congenital heart disease in low‐and‐middle‐income countries: Focus on sub‐Saharan Africa

Factors Associated with Congenital Heart Diseases among Children in Uganda: A Case-Control Study at Mulago National Referral Hospital (Uganda Heart Institute)

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