High prevalence of the hepatitis C virus infection among the inpatients of schizophrenia and psychoactive substance abuse in Japan

Nakamura, Yu; Koh, Motoasa; Miyoshi, Eiji; Ida, Osamu; Morikawa, Masayuki; Tokuyama, Akihiro; Nagano, Tatsuji; Honda, Yoshiharu; Iida, Junzo; Yamamoto, Kunya; Minami, Naoki; Kasahara, Akinori; Hirai, Makoto; Hayashi, Norio; Kishimoto, Toshifumi

doi:10.1016/j.pnpbp.2004.01.018

Cited by 26 publications

(9 citation statements)

References 19 publications

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“…The estimated HCV prevalence was 1–1.9%. Published estimates come from a large number of blood donor (138, 143–149) and subgroup‐based studies throughout the country from 1991 to 2010 (140, 141, 145, 147, 150–184). A study of pregnant women in 1990–1994 found a prevalence of 0.3% in women <40, and 1.8% in women over 40, suggestive of the importance of historical risk factors (140).…”

Section: Resultsmentioning

confidence: 99%

A systematic review of hepatitis C virus epidemiology in Asia, Australia and Egypt

Sievert

Altraif

Razavi

et al. 2011

Liver International

491

379

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Background: The hepatitis C pandemic has been systematically studied and characterized in North America and Europe, but this important public health problem has not received equivalent attention in other regions. Aim: The objective of this systematic review was to characterize hepatitis C virus (HCV) epidemiology in selected countries of Asia, Australia and Egypt, i.e. in a geographical area inhabited by over 40% of the global population. Methodology: Data references were identified through indexed journals and non‐indexed sources. In this work, 7770 articles were reviewed and 690 were selected based on their relevance. Results: We estimated that 49.3–64.0 million adults in Asia, Australia and Egypt are anti‐HCV positive. China alone has more HCV infections than all of Europe or the Americas. While most countries had prevalence rates from 1 to 2% we documented several with relatively high prevalence rates, including Egypt (15%), Pakistan (4.7%) and Taiwan (4.4%). Nosocomial infection, blood transfusion (before screening) and injection drug use were identified as common risk factors in the region. Genotype 1 was common in Australia, China, Taiwan and other countries in North Asia, while genotype 6 was found in Vietnam and other Southeast Asian countries. In India and Pakistan genotype 3 was predominant, while genotype 4 was found in Middle Eastern countries such as Egypt, Saudi Arabia and Syria. Conclusion: We recommend implementation of surveillance systems to guide effective public health policy that may lead to the eventual curtailment of the spread of this pandemic infection.

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Section: Resultsmentioning

confidence: 99%

A systematic review of hepatitis C virus epidemiology in Asia, Australia and Egypt

Sievert

Altraif

Razavi

et al. 2011

Liver International

491

379

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“…In Japan, Sawayama et al studied 196 neuropsychiatric patients and found that 10.2% of the patients were HCAb positive compared to 1.5% of controls and 44.4% were HBcAb positive compared to 20.5% of controls [7]. Nakamura et al studied 1,193 psychiatric patients in Japan and found 9.1% positive for HCAb compared to an estimated 1.2% HCAb positivity rate in the general Japanese population [9]. Despite differences in serologic testing parameters and specific psychiatric diagnoses, all of these studies suggest that patients with psychiatric disease are at increased risk of HBV and HCV exposure.…”

Section: Resultsmentioning

confidence: 99%

“…Studies from various countries have found an increased prevalence of two-to three-fold with HBV and two-to eight-fold with HCV in patients with psychiatric illness compared to those without [3][4][5][6][7][8][9][10]. The ubiquity of exposure to risk-conferring lifestyles and behavior in those with severe psychiatric illness is likely related to this increased prevalence.…”

Section: Introductionmentioning

confidence: 99%

Hepatitis B and C Among Veterans on a Psychiatric Ward

et al. 2007

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Hepatitis B and C are public health problems. Psychiatric patients may be at risk of hepatitis B and C exposure due to lifestyle and inadequate health care. We aimed to determine prevalence of hepatitis B and C virus exposure and associated risk factors in acutely hospitalized psychiatric veterans. A total of 234 individuals consecutively admitted to the psychiatric wards at the West Los Angeles Veterans Affairs Hospital were asked to participate. A total of 129 patients consented and were screened for viral hepatitis risk factors, hepatitis B surface antigen, hepatitis B surface and core antibodies, and hepatitis C antibodies. About 31 and 38% of the patients had been exposed to hepatitis B and C viruses, respectively. Several risk factors were associated with exposure. Inpatient psychiatric veterans seem to have increased rates of hepatitis B and C exposure. This highlights the need for prevention of risk behavior in this vulnerable population.

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“…13 Although a number of practice guidelines have proposed some recommendation in screening and follow-up for metabolic syndrome for patients on antipsychotic treatment, there has been no such consensus or recommendation for monitoring and proper management of abnormal liver function test or possible hepatic toxicity in antipsychotic-treated patients yet. 13 Although a number of practice guidelines have proposed some recommendation in screening and follow-up for metabolic syndrome for patients on antipsychotic treatment, there has been no such consensus or recommendation for monitoring and proper management of abnormal liver function test or possible hepatic toxicity in antipsychotic-treated patients yet.…”

mentioning

confidence: 99%

Antipsychotics and Abnormal Liver Function Tests

Pae¹

2012

Clinical Neuropharmacology

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High prevalence of the hepatitis C virus infection among the inpatients of schizophrenia and psychoactive substance abuse in Japan

Cited by 26 publications

References 19 publications

A systematic review of hepatitis C virus epidemiology in Asia, Australia and Egypt

A systematic review of hepatitis C virus epidemiology in Asia, Australia and Egypt

Hepatitis B and C Among Veterans on a Psychiatric Ward

Antipsychotics and Abnormal Liver Function Tests

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